Group Members

Jean-Yves Winum, Professor of Chemistry, Montpellier University.
Tel: 04 48 79 20 48

Jean-Yves Winum received his PhD in organic chemistry from the University of Montpellier (France) in 1998 under the supervision of Prof. Jean-Louis Montero. He then worked as a postdoctoral fellow in the Prof. Stefan Matile Group at the chemistry department of Georgetown University (Washington, DC, USA) and at the University of Geneva (Switzerland). In 1999, he joined the University of Montpellier, where he is now Full Professor at the Institute of Biomolecules Max Mousseron (ChemBioNAC team). His research interests are focused on organic/medicinal chemistry of metalloenzyme inhibitors and their applications as anti-cancer or anti-infective agents. The results of his studies have been published in more than 190 articles, 1 book, and 12 book chapters. He is an associate editor of Journal of Enzyme Inhibition and Medicinal Chemistry and a member of the editorial board of Expert Opinion on Therapeutic Patents, and Anti-Cancer Agents in Medicinal Chemistry.

Publications.

François Morvan, Research Director, Montpellier Inserm.
Tel: 04 48 79 20 50

François Morvan received his PhD in organic chemistry (1988) at the University of Montpellier (France) under the supervision of Dr Rayner and Prof. Imbach on the synthesis of α-DNA. In 1989, he was hired at the Inserm on modified oligonucleotides for antisense applications. From 1992 to 1993, he worked at Ionis Pharmaceuticals (ex ISIS Pharmaceuticals, USA, CA) as a senior visiting scientist. He returned to the University of Montpellier where he is currently Research Director at the Inserm since 2006. In the ChemBioNAC team of the Institute of Biomolecules Max Mousseron, his research focuses on modified oligonucleotides and their conjugates for diagnostic and therapeutic applications, design of neoglycocluster oligonucleotide conjugates and original G-quadruplex analogs. Currently, he develops DNA-inspired aromatic foldamers.

Publications

Christelle Dupouy, Assistant Professor, Montpellier University.
Tel: 04 48 79 20 52

Christelle Dupouy received her Ph.D in 2007 from the University of  Toulouse III- Paul Sabatier under the supervision of Dr Jean-Marc Escudier, on the synthesis and properties of constrained dinucleotides. She, then joined the Prof. J. Chattopadhayaya’s group at Uppsala University (Sweden) for a one year post-doctorate fellow. She worked on the synthesis of modified nucleosides for antisense applications. In 2008, she moved to the Dr Pochet’s team at Institut Pasteur in Paris as a postdoctoral fellow to develop inhibitors of N-glycosylase.
Since 2009, she joined the University of Montpellier as Assistant Professor in the ChemBioNAC team of the Institute of Biomolecules Max Mousseron (IBMM). Her research interests focus on RNA modifications for therapeutics applications and for understanding the RNA folding.

Publications

Guillaume Clavé, Researcher, CNRS.
Tel: 04 48 79 20 57

Dr. Guillaume Clavé received an engineering degree from the École Nationale Supérieure des Industries Chimiques de Nancy in 2005. He obtained his Ph.D. in organic chemistry from Rouen Normandie University in 2009 under the supervision of Pr. Pierre-Yves Renard working on new bioconjugation reagents. He then joined the CEA (Paris-Saclay University) for a one year post-doctorate fellow in the Laboratoire d’Études et de Recherches en Immunoanalyse led by Dr. Hervé Volland to work on protein conjugates for monoclonal antibodies production, followed by two additional years under the supervision of Dr. Stephane Campidelli at the Laboratoire d’Électronique Moléculaire were he was interested to carbon nanotubes or fullerene / DNA conjugates. Thereafter, in 2012 he joined the group of Jean-Marie Beau at the Institut de Chimie des Substances Naturelles (Gif-sur-Yvette) to develop original florigenic or radioactive probes derived from plant hormones. In 2014, he was recruited as a CNRS Researcher in the ChimEco laboratory directed by Dr. Claude Grison to work on sustainable processes. Since 2018, he joined the ChemBioNac team led by Pr. Michael Smietana at the Institut des Biomolecules Max Mousseron of Montpellier. His current research interests concern the elaboration of nucleic acid bioconjugates and bioactive molecules derived from nucleic acids.

Publications

Pauline Adler, Assistant Professor, Montpellier University.
Tel: 04 48 79 20 52

Pauline Adler was educated at the Ecole Normale Supérieure in Cachan, where she passed the ‘Agrégation’ of Physics and Chemistry with success. She received her PhD of the University of Paris-Saclay – Paris Sud in 2016 under the direction of Dr. Nicolas Rabasso, on the study of the synthesis and reactivity of unsaturated aminophosphonates. She worked as a postdoctoral researcher in the group of Prof. Maulide in Vienna (Austria) for almost 2 years (2017 – 2018). Her work was focused on the chemoselective activation of amides. She came back to France for two consecutive one-year-position as Assistant professor in the group of Pr. Grison in the University of Montpellier, working on the development of biobased-catalysts (2018 – 2020). Then, she did a second post-doctoral contract at the IBMM (University of Montpellier) under the supervision of Dr. Jean-François Hernandez. Her work focused on the preparation of pseudopeptides with antimalarial activities, in collaboration with Pasteur Institute (2020 – 2021). Since September 2021, she works as an Assistant Professor in the ChemBioNAC team of the IBMM, in Montpellier. Her research interests focus on the development of DNA-compatible reactions and DNA-based catalysis.

Publications

Emmanuelle Remond, Associate Professor, Montpellier University.
Tel: 04 48 79 20 49

Emmanuelle Rémond received her PhD of the University of Bourgogne in 2010 under the supervision of Pr. Sylvain Jugé, on the Wittig reaction in amino acid series and P-chirogenic phosphorus chemistry. She completed her research training through an internship with Pr. Naoto Chatani and Pr. Hiroaki Sasai in Osaka, and then, as a postdoctoral fellowship in the team of Pr. K. Maruoka in Kyoto University, in 2011. During this period her research focused on the catalyzed borylation of unactivated nitriles, and on asymmetric organocatalysis using P-chirogenic phosphines as Lewis bases and chiral primary diamines, respectively. In 2012, she was appointed assistant professor at the University of Bourgogne, and then associate professor in 2013 at the University of Montpellier. She joined the team directed by Dr. Florine Cavelier at IBMM to develop heterosubstituted amino acids and their uses for peptide labeling either with fluorescent phospholes or for TEP imaging. Since 2025, she joined the ChemBioNac team led by Pr. Michael Smietana, where her current research focus on phospholes for the development of nucleic acid conjugates or as photosensitizers for photodynamic therapy.

Publications