2026
A metal-DNA biohybrid as enantioselective artificial photoDNAzyme
Z. Pastorel, J. Zanzi, M. Noël, A. Bartocci, S. Arseniyadis, E. Dumont, Y. Canac, O. Baslé, M. Smietana
Nat. Commun. 2026,
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA
V. Basse, T. Agarwal, T. Sneideris, C.-A. Richard, J. Troussier, J.-J.
Vasseur, Françoise Debart, Jean-François Eléouët, E. de Csillery, T. Knowles, M. Galloux
Sci. Adv. 2026, 12, eaee2110
Harnessing Oligonucleotide Architecture for Potent Multivalent Inhibition of Human Carbonic Anhydrases
E. M. Abbass, F. Ladu, J. Mansot, M. Noël, A. Nocentini, M. Sechi, C. T. Supuran, M. Smietana, J-Y. Winum
RSC Med. Chem. 2026, 17, 1961.
Proximity-Induced Ligation of Noncomplementary Oligonucleotides Triggered by Charge-Transfer Interactions
L. Nicollet, K. Pérez de Carvasal, N. Graidia, F. Morvan, M. Smietana
ChemistryEurope 2026, 4, e202500421
When the Position of Pendant Groups Makes the Difference in G-Quadruplex Behavior: The Case of Bis-Conjugated Thrombin-Binding Aptamers.
C. Platella, F. Battistini, C. Riccardi, M. Smietana, F. Morvan, M. Orozco, D. Montesarchio
J. Chem. Inf. Model. 2026, 66, 642.
2025
Synthesis, duplex-forming properties, and enzymatic resistance of oligonucleotides containing N-acylsulfonamide linkages
R. Amador, C. Baraguey, G. Clavé, M. Smietana
Org. Biomol. Chem., 2025, 23, 9576
Synthesis and in vitro inhibitory activity of N-arylsulfonamide adenosine analogues designed to target SARS-CoV-2 nsp14 N7-methyltransferase
M. Hausdorff, A. Delpal, H. Machin, A. Tahir, J. Zoladek, F. Gucciardi, J. Swain, N. Gros, D. Muriaux, S. Nisole, B. Canard, J.-J. Vasseur, E. Decroly, F. Debart
Bioorg. Chem. 2025, 166, 109104
Selective Inhibition of Carbonic Anhydrase IX and XII by Natural Coumarin Coladonin and Its Derivatives: Promising Antimelanoma and Antiglioblastoma Agents
M. Mustafa, W. Baccari, A. Nocentini, M. L. Massardi, M. Smietana, E. M. Abbass, I. Saidi, M. Znati, H. B. Jannet, R. Ronca, C. T. Supuran, J.-Y. Winum
ACS Med. Chem. Lett. 2025, 16, 1190–1196
Synthesis and Base-Pairing Properties of Oligonucleotides Containing 5′-(R)- and 5′-(S)-C-Aryl-thymidine
M. Hausdorff, A. Van der Lee, M. A. Maverick, J.-J. Vasseur, F. Debart, M. Smietana
J. Org. Chem. 2025, 90, 26, 8986–9001
Design, Synthesis, and In Vitro Anticancer Evaluation of Thiazole-Based Chalcones Linked to Sulfanilamide as Tumor-Associated Carbonic Anhydrase IX and XII Inhibitors
A. M. Elshamsy, M. Mustafa, A. Nocentini, M. L. Massardi, T. F. S. Ali, S. M. Rabea, B. Tüzün, M. Smietana, S. Kapancık, M. Abdel-Aziz, R. Ronca, C. T. Supuran, J.-Y. Winum, H. Hashem
J. Med. Chem. 2025, 68, 15151–15164
Peptide–Oligonucleotide Conjugates: Catalytic Preparation in Aqueous Solution or On-Column
M. Gras, M. Smietana, P. Adler
Current Protocols, 2025, 5, e70154
Recent Development of DNA-based Biohybrid Systems Driven by Light
Z. Pastorel, J. Zanzi, Y. Canac, O. Baslé, M. Smietana
Eur. J. Org. Chem. 2025, 28, e202401297
2024
Accelerated, high quality photolithographic synthesis of RNA microarrays in situ
T. Kekic, N. Milisavljevic, J. Troussier, A. Tahir, F. Debart and J. Lietard
Science Advances 2024, 10, eado6762
Synthesis of acyclic analogues of adenosine sulfonamides and their activity against RNA cap guanine N7-methyltransferase of SARS-CoV-2
R. Ahmed-Belkacem, A. Delpal, B. Canard, J.-J. Vasseur, E. Decroly and F. Debart
New Journal of Chemistry, 2024, 48, 17692-17695
Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity
S. Giovannuzzi, A. Nikitjuka, A. Angeli, M. Smietana, M.-L. Massardi, M. Turati, R. Ronca, A. Bonardi, A. Nocentini, M. Ferraroni, C. T. Supuran*, J.-Y. Winum*
J. Med. Chem. 2024, 67, 18221–18234
Counterion Effects in [Ru(bpy)3](X)2-Photocatalyzed Energy Transfer Reactions
J. Zanzi, Z. Pastorel, C. Duhayon, E. Lognon, C. Coudret, A. Monari, I. M. Dixon, Y. Canac, M. Smietana,* O. Baslé*
JACS Au 2024, 4, 3049–3057
Phthalimide and 3-Formylindole Derivatives for Oligonucleotide Conjugation by Amide or Oxime Ligation
N. Graidia, A. Meyer, M. Smietana, F. Morvan*
Eur. J. Org. Chem. 2024, 27, e202400458
N-arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2.
Ahmed-Belkacem, R.; Troussier, J.; Delpal, A.; Canard, B.; Vasseur, J.-J.; Decroly, E.; Debart, F.
RSC Medicinal Chemistry 2024, 15, 839-847.
5′-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2′-O-methyltransferases.
Ahmed-Belkacem, R.; Sutto-Ortiz, P.; Delpal, A.; Troussier, J.; Canard, B.; Vasseur, J.-J.; Decroly, E.; Debart, F.
Bioorg. Chem. 2024,143, 107035.
A Catalytic Approach for the Synthesis of Peptide–Oligonucleotides Conjugates in Aqueous Solution or On-Column
M. Gras, P. Adler, M. Smietana
Chem. Eur. J., 2024, e202401069.
The hydrazine moiety in the synthesis of modified nucleosides and nucleotides
A. Guillou, S. Peyrottes, J.-J. Vasseur, C. Mathe, M. Smietana
ChemMedChem, 2024, e202400234
Synthesis of original cyclic dinucleotide analogues using the sulfo-click reaction
R. Amador, J.-J. Vasseur, G. Birkus, E. Bignon, A. Monari, G. Clavé,* M. Smietana
Organic Letters, 2024, 26, 819-823
Boron-containing carbonic anhydrases inhibitors
S. Giovannuzzi, A. Nikitjuka, B. R Peirera Resende, M. Smietana, A. Nocentini,* C.T. Supuran, J.Y. Winum*
Bioorg. Chem., 2024, 143, 106976
Synthesis and properties of RNA constrained by a 2’-O-disulfide bridge
D. Traoré, E. Biecher, M. Mallet, S. Rouanet, J.-J. Vasseur, M. Smietana, C. Dupouy*
ChemistryOpen., 2024, e202300232
A synthetic thiol molecule releasing N-acetyl-L-cysteine and cysteamine drives early up-regulation of immunoproteasome subunits in the lymph nodes of mice infected with LP-BM5 leukemia retrovirus
R. Crinelli,* F. Monittola, S. Masini, A. Diotallevi, F. Bartoccini, M. Smietana, L. Galluzzi, M. Magnani, A. Fraternale
BBA Molecular Basis of Disease., 2024, 1870, 166918
Serendipitous Synthesis of 5-Hydroxyuridine from 2′,3′-O-Isopropylidene N4
Acetylcytidine by Hypervalent Iodine(III)-Mediated Reaction
M. A. Maverick, M. Noël, J-J. Vasseur, C. Baraguey∗, F. Debart*, M. Smietana*
Synlett, 2024, 34, 684-690
2023
Access to High-Purity 7mG-cap RNA in Substantial Quantities by a Convenient All-Chemical Solid-Phase Method
M. Noël, T. Guez, Y. Thillier, J.-J. Vasseur, F. Debart
ChemBioChem, 2023, 24, e2023005
Probing naphthalene diimide and 3-hydroxypropylphosphate as end-conjugating moieties for improved thrombin binding aptamers: Structural and biological effects
C. Ricardi, K. Perez de Carvasal, C. Platella, A. Meyer, M. Smietana, F. Morvan,* D. Montesarchio*
Bioorg. Chem., 2023, 141, 106917
N-Acylsulfonamide: a valuable moiety to design new sulfa drug analogues
R. Amador, A. Tahrioui, M. Barreau, O. Lesouhaitier, M. Smietana*, G. Clavé*
RSC Med. Chem., 2023, 14, 1567-1571
6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography
A. Nocentini, A. Bonardi, C. Bazzicalupi, V. Alterio, D. Esposito, S. Maria Monti, M. Smietana, G. De Simone, C. T. Supuran, P. Gratteri*, J.-Y. Winum*
J. Med. Chem, 2023, 66, 8118-8129
Stabilization of DNA Duplexes and Hairpins by Charge-Transfer Interactions Using DAN:NDI Pairs
K. Pérez de Carvasal , L. Nicollet , M. Smietana* , F. Morvan*
ACS Langmuir, 2023, 39, 7418-7425
Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases
M. Hausdorff, A. Delpal, S. Barelier, L. Nicollet, B. Canard, F. Touret, A. Colmant, B. Coutard, J.-J. Vasseur, E. Decroly, F. Debart*
Eur. J. Med. Chem., 2023, 256, 115474
AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5
Feracci, M., Eydoux, C., Fattorini, V., Lo Bello, L., Gauffre, P., Selisko, B., Sutto-Ortiz, P., Shannon, A., Xia, H., Shi, P.-Y., Noel, M., Debart, F., Vasseur, J.-J., Good, S., Lin, K., Moussa, A., Sommadossi, J.-P., Chazot, A., Alvarez, K., Guillemot, J.-C., Decroly, E., Ferron, F., Canard, B.
Antiviral Res., 2023, 105574.
Internal RNA 2’O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect
El Kazzi, P., Rabah, N., Chamontin, C., Poulain, L., Ferron, F., Debart, F., Canard, B., Missé, D., Coutard, B., Nisole, S. et al.
Nucleic Acids Res., 2023, 51, 2501-2515.
Catalytic and Sustainable Amide Bond Formation using a DABCO/Dichlorotriazine System
P. Adler,* M. Gras, M. Smietana*
ChemCatChem., 2023, e202300264
Boronic Acid Assisted Self-Assembly of Functional RNAs
A. Lelievre-Buttner, T. Schnarr, M. Debiais, M. Smietana,* S. Müller*
Chem. Eur. J. ., 2023, e202300196
Expanding the ‘aplysinospin cascade’ through DNA-templated [2+2] photocycloaddition
S. Oger, N. Duchemin, Y. M. Bendiab, N. Birlirakis, A. Skired, S. Rharrabti, J.-C. Jullian, E. Poupon,* M. Smietana,* S. Arseniyadis,* L. Evanno*
Chem. Commun., 2023, 59, 4221-4224
Supramolecular Recognition of Phosphodiester-Based Donor and Acceptor Oligomers Forming Gels in Water
K. Pérez de Carvasal, G. Vergoten, J. J. Vasseur, M. Smietana,* F. Morvan*
Biomacromolecules, 2023, 24, 756-765
2022
Importance of RNA length for in vitro encapsidation by the nucleoprotein of human Respiratory Syncytial Virus
Gonnin, L., Richard, C.-A., Gutsche, I., Chevret, D., Troussier, J., Vasseur, J.-J., Debart, F., Eléouët, J.-F. and Galloux, M.
J. Biol. Chem., 2022, 298, 102337.
A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers
R. Troisi, C. Riccardi, K. Pérez de Carvasal, M. Smietana, F. Morvan, P. Del Vecchio, D. Montesarchio, F. Sica
Molecular Therapy: Nucleic Acids, 2022, 30, 585-594
A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome
A. Shannon, B. Sama, P. Gauffre, T. Guez, F. Debart, J.-J. Vasseur, E. Decroly, B. Canard, F. Ferron
Nucleic Acid Research, 2022, 50, 11186-11198.
Facile access to 4′-(N-acylsulfonamide) modified nucleosides and evaluation of their
inhibitory activity against SARS-CoV-2 RNA cap N7-guanine-methyltransferase nsp14
R. Amador, A. Delpal, B. Canard, J.-J. Vasseur, E. Decroly, F. Debart, G. Clavé,* M. Smietana*
Organic Biomolecular Chemistry, 2022, 20, 7582-7586.
A modular spring-loaded actuator for mechanical activation of membrane proteins
A. Mills, N. Aissaoui, D. Maurel, J. Elezgaray, F. Morvan, J. J. Vasseur, E. Margeat, R. B. Quast,
J. Lai Kee-Him, N. Saint, C. Benistant, A. Nord , F. Pedaci, G. Bellot
Nature Communications 2022, 13, 3182
New Benchmark in DNA-Based Asymmetric Catalysis: Prevalence of Modified DNA/RNA Hybrid Systems
N. Duchemin, S. Aubert, J. V. de Souza, L. Bethge, S. Vonhoff, A. K. Bronowska, M. Smietana,* S. Arseniyadis*
JACS Au 2022, 2, 1910-1917
Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate
Analogues.
Ahmed-Belkacem, R.; Hausdorff, M.; Delpal, A.; Sutto-Ortiz, P.; Colmant, A. M. G.; Touret, F.;
Ogando, N. S.; Snijder, E. J.; Canard, B.; Coutard, B.; Vasseur, J.-J.; Decroly, E.; Debart, F., Potent
J. Med. Chem. 2022, 65 (8), 6231-6249.
The Institute of Biomolecules Max Mousseron: A Timely Move
M. Smietana,* P. Dumy*
Eur. J. Org. Chem. 2022, e202101322
Design and NMR characterization of reversible headto-tail boronate-linked macrocyclic nucleic acids
M. Debiais, A. Gimenez Molina, S. Müller, J.J. Vasseur, I. Barvik, C. Baraguey,* M. Smietana*
Org. Biomol. Chem. 2022, 20, 2889
Applications of the Reversible Boronic Acids/Boronate Switch to Nucleic Acids
M. Debais, J.J. Vasseur, M. Smietana*
Chem. Rec. 2022, e202200085
Direct Access to Unique C-5’-Acyl Modified Nucleosides through Liebeskind–Srogl Cross-Coupling Reaction
M. A. Maverick, M. Gaillard, J.J. Vasseur, F. Debart,* M. Smietana*
Eur. J. Org. Chem. 2022, e202101061
