Jean-Jacques Vasseur
228. A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome
A. Shannon, B. Sama, P. Gauffre, T. Guez, F. Debart, J.-J. Vasseur, E. Decroly, B. Canard, F. Ferron
Nucleic Acid Research, 2022, 50, 11186–11198
227. Facile access to 4′-(N-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N7-guanine-methyltransferase nsp14
R. Amador, A. Delpal, B. Canard, J.-J. Vasseur, E. Decroly, F. Debart, G. Clavé,* M. Smietana*
Organic Biomolecular Chemistry, 2022, 20, 7582-7586.
226. A modular spring-loaded actuator for mechanical activation of membrane proteins.
Mills, A.; Aissaoui, N.; Maurel, D.; Elezgaray, J.; Morvan, F.; Vasseur, J. J.; Margeat, E.; Quast, R. B.; Kee-Him, J. L.; Saint, N.; Benistant, C.; Nord, A.; Pedaci, F.; Bellot, G.
Nat. Commun. 2022, 13 (1), 10. https://10.1038/s41467-022-30745-2.
225. Oligonucleotide Conjugation by Tyrosine-Click Reaction.
Meyer, A.; Baraguey, C.; Vasseur, J. J.; Morvan, F.
Eur. J. Org. Chem. 2022, 2022 (21), 10. https://10.1002/ejoc.202101361.
224. Direct Access to Unique C-5′-Acyl Modified Nucleosides through Liebeskind-Srogl Cross-Coupling Reaction.
Maverick, M. A.; Gaillard, M.; Vasseur, J. J.; Debart, F.; Smietana, M.
Eur. J. Org. Chem. 2022, 2022 (21), 5. https://10.1002/ejoc.202101061.
223. Applications of the Reversible Boronic Acids/Boronate Switch to Nucleic Acids.
Debiais, M.; Vasseur, J. J.; Smietana, M.
Chem. Rec. 2022, 17. https://10.1002/tcr.202200085.
222. Design and NMR characterization of reversible head-to-tail boronate-linked macrocyclic nucleic acids.
Debiais, M.; Molina, A. G.; Muller, S.; Vasseur, J. J.; Barvik, I.; Baraguey, C.; Smietana, M.
Org. Biomol. Chem. 2022, 20 (14), 2889-2895. https://10.1039/d2ob00232a.
221. Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues.
Ahmed-Belkacem, R.; Hausdorff, M.; Delpal, A.; Sutto-Ortiz, P.; Colmant, A. M. G.; Touret, F.; Ogando, N. S.; Snijder, E. J.; Canard, B.; Coutard, B.; Vasseur, J. J.; Decroly, E.; Debart, F.
J. Med. Chem. 2022, 65 (8), 6231-6249. https://10.1021/acs.jmedchem.2c00120.
220. Bisubstrate Strategies to Target Methyltransferases.
Ahmed-Belkacem, R.; Debart, F.; Vasseur, J. J.
Eur. J. Org. Chem. 2022, 2022 (21), 12. https://10.1002/ejoc.202101481.
219. First insights into the structural features of Ebola virus methyltransferase activities.
Valle, C.; Martin, B.; Ferron, F.; Roig-Zamboni, V.; Desmyter, A.; Debart, F.; Vasseur, J. J.; Canard, B.; Coutard, B.; Decroly, E.
Nucleic Acids Res. 2021, 49 (3), 1737-1748. https://10.1093/nar/gkaa1276.
218. The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2′-O-methylation.
Sutto-Ortiz, P.; Tcherniuk, S.; Ysebaert, N.; Abeywickrema, P.; Noel, M.; Decombe, A.; Debart, F.; Vasseur, J. J.; Canard, B.; Roymans, D.; Rigaux, P.; Eleouet, J. F.; Decroly, E.
PLoS Pathog. 2021, 17 (5), 20. https://10.1371/journal.ppat.1009562.
217. FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell.
Relier, S.; Ripoll, J.; Guillorit, H.; Amalric, A.; Achour, C.; Boissiere, F.; Vialaret, J.; Attina, A.; Debart, F.; Choquet, A.; Macari, F.; Marchand, V.; Motorin, Y.; Samalin, E.; Vasseur, J. J.; Pannequin, J.; Aguilo, F.; Lopez-Crapez, E.; Hirtz, C.; Rivals, E.; Bastide, A.; David, A.
Nat. Commun. 2021, 12 (1), 13. https://10.1038/s41467-021-21758-4.
216. Folding of phosphodiester-linked donor-acceptor oligomers into supramolecular nanotubes in water.
Perez de Carvasal, K.; Aissaoui, N.; Vergoten, G.; Bellot, G.; Vasseur, J. J.; Smietana, M.; Morvan, F.
Chem. Commun. 2021, 57 (34), 4130-4133. https://10.1039/d1cc01064f.
215. Diagnostic Performance of a Magnetic Field-Enhanced Agglutination Readout in Detecting Either Viral Genomes or Host Antibodies in Arbovirus Infection.
Leon, F.; Pinchon, E.; Temurok, N.; Morvan, F.; Vasseur, J. J.; Clot, M.; Foulongne, V.; Cantaloube, J. F.; Vande Perre, P.; Moles, J. P.; Daynes, A.; Fournier-Wirth, C.
Microorganisms 2021, 9 (4), 12. https://10.3390/microorganisms9040674.
214. Boronic Acid-Mediated Activity Control of Split 10-23 DNAzymes.
Debiais, M.; Lelievre, A.; Vasseur, J. J.; Muller, S.; Smietana, M.
Chem. Eur. J. 2021, 27 (3), 1138-1144. https://10.1002/chem.202004227.
213. Charge-Transfer Interactions Stabilize G-Quadruplex-Forming Thrombin Binding Aptamers and Can Improve Their Anticoagulant Activity.
de Carvasal, K. P.; Riccardi, C.; Krauss, I. R.; Cavasso, D.; Vasseur, J. J.; Smietana, M.; Morvan, F.; Montesarchio, D.
Int. J. Mol. Sci. 2021, 22 (17), 23. https://10.3390/ijms22179510.
212. Modified internucleoside linkages for nuclease-resistant oligonucleotides.
Clave, G.; Reverte, M.; Vasseur, J. J.; Smietana, M.
RSC Chem. Biol. 2021, 2 (1), 94-150. https://10.1039/d0cb00136h.
211. Efficient one-pot, three-component procedure to prepare new alpha-aminophosphonate and phosphonic acid acyclic nucleosides.
Baddi, L.; Ouzebla, D.; El Mansouri, A. E.; Smietana, M.; Vasseur, J. J.; Lazrek, H. B.
Nucleosides Nucleotides Nucleic Acids 2021, 40 (1), 43-67. https://10.1080/15257770.2020.1826516.
210. The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation.
Valle, C.; Martin, B.; Debart, F.; Vasseur, J. J.; Imbert, I.; Canard, B.; Coutard, B.; Decroly, E.
J. Virol. 2020, 94 (12), 14. https://10.1128/jvi.00520-20.
209. Fine-tuning the properties of the thrombin binding aptamer through cyclization: Effect of the 5 ‘-3 ‘ connecting linker on the aptamer stability and anticoagulant activity.
Riccardi, C.; Meyer, A.; Vasseur, J. J.; Krauss, I. R.; Paduano, L.; Morvan, F.; Montesarchio, D.
Bioorganic Chem. 2020, 94, 14. https://10.1016/j.bioorg.2019.103379.
208. Design, Synthesis and Characterization of Cyclic NU172 Analogues: A Biophysical and Biological Insight.
Riccardi, C.; Meyer, A.; Vasseur, J. J.; Cavasso, D.; Krauss, I. R.; Paduano, L.; Morvan, F.; Montesarchio, D.
Int. J. Mol. Sci. 2020, 21 (11), 26. https://10.3390/ijms21113860.
207. Rapid and specific DNA detection by magnetic field-enhanced agglutination assay.
Pinchon, E.; Leon, F.; Temurok, N.; Morvan, F.; Vasseur, J. J.; Clot, M.; Foulongne, V.; Cantaloube, J. F.; Vande Perre, P.; Daynes, A.; Moles, J. P.; Fournier-Wirth, C.
Talanta 2020, 219, 6. https://10.1016/j.talanta.2020.121344.
206. La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region (vol 46, pg 1457, 2018).
Philippe, L.; Vasseur, J. J.; Debart, F.; Thoreen, C. C.
Nucleic Acids Res. 2020, 48 (13), 7604-7605. https://10.1093/nar/gkaa535.
205. Machine Learning to Improve the Sensing of Biomolecules by Conical Track-Etched Nanopore.
Meyer, N.; Janot, J. M.; Lepoitevin, M.; Smietana, M.; Vasseur, J. J.; Torrent, J.; Balme, S.
Biosensors-Basel 2020, 10 (10), 13. https://10.3390/bios10100140.
204. DNA-Based Asymmetric Inverse Electron-Demand Hetero-Diels-Alder.
Mansot, J.; Lauberteaux, J.; Lebrun, A.; Mauduit, M.; Vasseur, J. J.; de Figueiredo, R. M.; Arseniyadis, S.; Campagne, J. M.; Smietana, M.
Chem. Eur. J. 2020, 26 (16), 3519-3523. https://10.1002/chem.202000516.
203. Modified Galacto- or Fuco-Clusters Exploiting the Siderophore Pathway to Inhibit the LecA- or LecB-Associated Virulence ofPseudomonas aeruginosa.
Madaoui, M.; Vidal, O.; Meyer, A.; Noel, M.; Lacroix, J. M.; Vasseur, J. J.; Marra, A.; Morvan, F.
ChemBioChem 2020, 21 (23), 3433-3448. https://10.1002/cbic.202000490.
202. Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers.
Gauthier, F.; Bertrand, J. R.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Molecules 2020, 25 (11), 15. https://10.3390/molecules25112714.
201. Selective Chemical Modification of DNA with Boronic Acids by On-Column CuAAc Reactions.
Debiais, M.; Vasseur, J. J.; Muller, S.; Smietana, M.
Synthesis 2020, 52 (20), 2962-2969. https://10.1055/s-0040-1707194.
200. An Entry of the Chemoselective Sulfo-Click Reaction into the Sphere of Nucleic Acids.
Clave, G.; Dursun, E.; Vasseur, J. J.; Smietana, M.
Org. Lett. 2020, 22 (5), 1914-1918. https://10.1021/acs.orglett.0c00265.
199. Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase.
Ahmed-Belkacem, R.; Sutto-Ortiz, P.; Guiraud, M.; Canard, B.; Vasseur, J. J.; Decroly, E.; Debart, F.
Eur. J. Med. Chem. 2020, 201, 16. https://10.1016/j.ejmech.2020.112557.
198. Deciphering multivalent glycocluster-lectin interactions through AFM characterization of the self-assembled nanostructures.
Zuttion, F.; Sicard, D.; Dupin, L.; Vergoten, G.; Girard-Bock, C.; Madaoui, M.; Chevolot, Y.; Morvan, F.; Vidal, S.; Vasseur, J. J.; Souteyrand, E.; Phaner-Goutorbe, M.
Soft Matter 2019, 15 (36), 7211-7218. https://10.1039/c9sm00371a.
197. Stability Is Not Everything: The Case of the Cyclisation of a Thrombin-Binding Aptamer.
Riccardi, C.; Meyer, A.; Vasseur, J. J.; Krauss, I. R.; Paduano, L.; Oliva, R.; Petraccone, L.; Morvan, F.; Montesarchio, D.
ChemBioChem 2019, 20 (14), 1789-1794. https://10.1002/cbic.201900045.
196. Difluorophosphonylated Allylic Ether Moiety as a 2 ‘-Modification of RNA-Type Molecules: Synthesis, Thermal, and Metabolic Studies.
Pfund, E.; Dupouy, C.; Rouanet, S.; Legay, R.; Lebargy, C.; Vasseur, J. J.; Lequeux, T.
Org. Lett. 2019, 21 (12), 4803-4807. https://10.1021/acs.orglett.9b01689.
195. Solid Supports for the Synthesis of 3 ‘-Aminooxy Deoxy- or Ribo-oligonucleotides and Their
3′-Conjugation by Oxime Ligation.
Noeel, M.; Cleement-Blanc, C.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2019, 84 (22), 14854-14860. https://10.1021/acs.joc.9b00848.
194. Combining Chemical Synthesis and Enzymatic Methylation to Access Short RNAs with Various 5 ‘ Caps.
Muthmann, N.; Guez, T.; Vasseur, J. J.; Jaffrey, S. R.; Debart, F.; Rentmeister, A.
ChemBioChem 2019, 20 (13), 1693-1700. https://10.1002/cbic.201900037.
193. FTO controls reversible m(6)Am RNA methylation during snRNA biogenesis.
Mauer, J.; Sindelar, M.; Despic, V.; Guez, T.; Hawley, B. R.; Vasseur, J. J.; Rentmeister, A.; Gross, S. S.; Pellizzoni, L.; Debart, F.; Goodarzis, H.; Jaffrey, S. R.
Nat. Chem. Biol. 2019, 15 (4), 340-+. https://10.1038/s41589-019-0231-8.
192. alpha,beta-Unsaturated 2-Acyl-Imidazoles in Asymmetric Biohybrid Catalysis.
Mansot, J.; Vasseur, J. J.; Arseniyadis, S.; Smietana, M.
ChemCatChem 2019, 11 (23), 5686-5704. https://10.1002/cctc.201900743.
191. A rational quest for selectivity through precise ligand-positioning in tandem DNA-catalysed Friedel-Crafts alkylation/asymmetric protonation.
Mansot, J.; Aubert, S.; Duchemin, N.; Vasseur, J. J.; Arseniyadis, S.; Smietana, M.
Chem. Sci. 2019, 10 (10), 2875-2881. https://10.1039/c8sc05543b.
190. Thermolytic Reagents to Synthesize 5-or 3-Mono(thio)phosphate Oligodeoxynucleotides or 3-modified oligodeoxynucleotides.
Madaoui, M.; Meyer, A.; Vasseur, J. J.; Morvan, F.
Eur. J. Org. Chem. 2019, 2019 (17), 2832-2842. https://10.1002/ejoc.201900302.
189. An Innovative Multiplexed and Flexible Molecular Approach for the Differential Detection of Arboviruses.
Leon, F.; Meyer, A.; Reynier, R.; Blanc, E.; Bruyere-Ostells, L.; Bres, J. C.; Simonin, Y.; Salinas, S.; Gallian, P.; Leparc-Goffart, I.; Biron, A.; Dupont-Rouzeyrol, M.; Morvan, F.; Vasseur, J. J.; Foulongne, V.; Van de Perre, P.; Cantaloube, J. F.; Fournier-Wirth, C.
J. Mol. Diagn. 2019, 21 (1), 81-88. https://10.1016/j.jmoldx.2018.08.005.
188. Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.
Larcher, A.; Nocentin, A.; Supuran, C. T.; Winum, J. Y.; van der Lee, A.; Vasseur, J. J.; Laurencin, D.; Smietana, M.
ACS Med. Chem. Lett. 2019, 10 (8), 1205-1210. https://10.1021/acsmedchemlett.9b00252.
187. Conjugation of Small Molecules to RNA Using a Reducible Disulfide Linker Attached at the 2 ‘-OH Position through a Carbamate Function.
Gauthier, F.; Malher, A.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Eur. J. Org. Chem. 2019, 2019 (33), 5636-5645. https://10.1002/ejoc.201900740.
186. Identification of the m(6)Am Methyltransferase PCIF1 Reveals the Location and Functions of m(6)Am in the Transcriptome.
Boulias, K.; Toczydlowska-Socha, D.; Hawley, B.; Liberman, N.; Takashima, K.; Zaccara, S.; Guez, T.; Vasseur, J. J.; Debart, F.; Aravind, L.; Jaffrey, S. R.; Greer, E. L.
Mol. Cell 2019, 75 (3), 631-+. https://10.1016/j.molcel.2019.06.006.
185. Synthesis of Adenine Dinucleosides 2 ‘,5 ‘-Bridged by Sulfur-Containing Linkers as Bisubstrate SAM Analogues for Viral RNA 2 ‘-O-Methyltransferases.
Ahmed-Belkacem, R.; Ortiz, P. S.; Decroly, E.; Vasseur, J. J.; Debart, F.
Eur. J. Org. Chem. 2019, 2019 (38), 6486-6495. https://10.1002/ejoc.201901120.
184. The anti-adhesive effect of glycoclusters on Pseudomonas aeruginosa bacteria adhesion to epithelial cells studied by AFM single cell force spectroscopy.
Zuttion, F.; Ligeour, C.; Vidal, O.; Walte, M.; Morvan, F.; Vidal, S.; Vasseur, J. J.; Chevolot, Y.; Phaner-Goutorbe, M.; Schillers, H.
Nanoscale 2018, 10 (26), 12771-12778. https://10.1039/c8nr03285h.
183. La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region.
Philippe, L.; Vasseur, J. J.; Debart, F.; Thoreen, C. C.
Nucleic Acids Res. 2018, 46 (3), 1457-1469. https://10.1093/nar/gkx1237.
182. RNA- based boronate internucleosidic linkages: an entry into reversible templated ligation and loop formation.
Molina, A. G.; Barvik, I.; Muller, S.; Vasseur, J. J.; Smietana, M.
Org. Biomol. Chem. 2018, 16 (45), 8824-8830. https://10.1039/c8ob02182a.
181. The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure.
Martin, B.; Coutard, B.; Guez, T.; Paesen, G. C.; Canard, B.; Debart, F.; Vasseur, J. J.; Grimes, J. M.; Decroly, E.
Nucleic Acids Res. 2018, 46 (15), 7902-7912. https://10.1093/nar/gky637.
180. Gymnotic delivery and gene silencing activity of reduction-responsive siRNAs bearing lipophilic disulfide-containing modifications at 2 ‘-position.
Gauthier, F.; Claveau, S.; Bertrand, J. R.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Bioorg. Med. Chem. 2018, 26 (16), 4635-4643. https://10.1016/j.bmc.2018.07.033.
179. A 2 ‘,2 ‘-disulfide-bridged dinucleotide conformationally locks RNA hairpins.
Gauthier, F.; Beltran, F.; Biscans, A.; Debart, F.; Dupouy, C.; Vasseur, J. J.
Org. Biomol. Chem. 2018, 16 (17), 3181-3188. https://10.1039/c8ob00328a.
178. Screening of a Library of Oligosaccharides Targeting Lectin LecB of Pseudomonas Aeruginosa and Synthesis of High Affinity Oligoglycoclusters.
Dupin, L.; Noel, M.; Bonnet, S.; Meyer, A.; Gehin, T.; Bastide, L.; Randriantsoa, M.; Souteyrand, E.; Cottin, C.; Vergoten, G.; Vasseur, J. J.; Morvan, F.; Chevolot, Y.; Darblade, B.
Molecules 2018, 23 (12), 24. https://10.3390/molecules23123073.
177. DNA-Templated 2+2 Photocycloaddition: A Straightforward Entry into the Aplysinopsin Family of Natural Products.
Duchemin, N.; Skiredj, A.; Mansot, J.; Leblanc, K.; Vasseur, J. J.; Beniddir, M. A.; Evanno, L.; Poupon, E.; Smietana, M.; Arseniyadis, S.
Angew. Chem. Int. Ed. 2018, 57 (36), 11786-11791. https://10.1002/anie.201806357.
176. Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing.
Debart, F.; Dupouy, C.; Vasseur, J. J.
Beilstein J. Org. Chem. 2018, 14, 436-469. https://10.3762/bjoc.14.32.
175. Template-directed excimer formation via specific non-covalent interactions between pyrene guanidinium derivatives and nucleic acids.
Amirbekyan, K.; Mansot, J.; Ohara, K.; Markarian, S. A.; Vasseur, J. J.; Smietana, M.
Tetrahedron Lett. 2018, 59 (3), 295-298. https://10.1016/j.tetlet.2017.12.046.
174. Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress.
Tamarkin-Ben-Harush, A.; Vasseur, J. J.; Debart, F.; Ulitsky, I.; Dikstein, R.
eLife 2017, 6, 21. https://10.7554/eLife.21907.
173. Fluorescent Thrombin Binding Aptamer-Tagged Nanoparticles for an Efficient and Reversible Control of Thrombin Activity.
Riccardi, C.; Krauss, I. R.; Musumeci, D.; Morvan, F.; Meyer, A.; Vasseur, J. J.; Paduano, L.; Montesarchio, D.
ACS Appl. Mater. Interfaces 2017, 9 (41), 35574-35587. https://10.1021/acsami.7b11195.
172. RNA-directed off/on switch of RNase H activity using boronic ester formation.
Reverte, M.; Barvik, I.; Vasseur, J. J.; Smietana, M.
Org. Biomol. Chem. 2017, 15 (38), 8204-8210. https://10.1039/c7ob02145c.
171. Contribution to PNA-RNA Chimera Synthesis: One-Pot Microwave-Assisted Ugi Reaction to Obtain Dimeric Building Blocks.
Ovadia, R.; Mondielli, C.; Vasseur, J. J.; Baraguey, C.; Alvarez, K.
Eur. J. Org. Chem. 2017, 2017 (3), 469-475. https://10.1002/ejoc.201601190.
170. Phthalimide-Oxy Derivatives for 3-or 5-Conjugation of Oligonucleotides by Oxime Ligation and Circularization of DNA by “Bis- or Tris-Click” Oxime Ligation.
Meyer, A.; Vasseur, J. J.; Dumy, P.; Morvan, F.
Eur. J. Org. Chem. 2017, 2017 (46), 6931-6941. https://10.1002/ejoc.201701317.
169. Reversible methylation of m(6)A(m) in the 5 ‘ cap controls mRNA stability.
Mauer, J.; Luo, X. B.; Blanjoie, A.; Jiao, X. F.; Grozhik, A. V.; Patil, D. P.; Linder, B.; Pickering, B. F.; Vasseur, J. J.; Chen, Q. Y.; Gross, S. S.; Elemento, O.; Debart, F.; Kiledjian, M.; Jaffrey, S. R.
Nature 2017, 541 (7637), 371-+. https://10.1038/nature21022.
168. Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
Coutard, B.; Barral, K.; Lichiere, J.; Selisko, B.; Martin, B.; Aouadi, W.; Lombardia, M. O.; Debart, F.; Vasseur, J. J.; Guillemot, J. C.; Canard, B.; Decroly, E.
J. Virol. 2017, 91 (5), 15. https://10.1128/jvi.02202-16.
167. Synthesis of 3 ‘-deoxy-3 ‘-iminodiacetic acid and 3 ‘-deoxy-3 ‘-aminodiethanol thymidine analogues and NMR study of their complexation with boronic acids.
Barbeyron, R.; Vasseur, J. J.; Baraguey, C.; Smietana, M.
Tetrahedron 2017, 73 (17), 2468-2475. https://10.1016/j.tet.2017.03.033.
166. Improved Performance of DNA Microarray Multiplex Hybridization Using Probes Anchored at Several Points by Thiol-Ene or Thiol-Yne Coupling Chemistry.
Banuls, M. J.; Jimenez-Meneses, P.; Meyer, A.; Vasseur, J. J.; Morvan, F.; Escorihuela, J.; Puchades, R.; Maquieira, A.
Bioconjugate Chem. 2017, 28 (2), 496-506. https://10.1021/acs.bioconjchem.6b00624.
165. Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay.
Aouadi, W.; Eydoux, C.; Coutard, B.; Martin, B.; Debart, F.; Vasseur, J. J.; Contreras, J. M.; Morice, C.; Querat, G.; Jung, M. L.; Canard, B.; Guillemot, J. C.; Decroly, E.
Antiviral Res. 2017, 144, 330-339. https://10.1016/j.antiviral.2017.06.021.
164. Binding of the Methyl Donor S-Adenosyl-L-Methionine to Middle East Respiratory Syndrome Coronavirus 2 ‘-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.
Aouadi, W.; Blanjoie, A.; Vasseur, J. J.; Debart, F.; Canard, B.; Decroly, E.
J. Virol. 2017, 91 (5), 18. https://10.1128/jvi.02217-16.
163. Design and Synthesis of Galactosylated Bifurcated Ligands with Nanomolar Affinity for Lectin LecA from Pseudomonas aeruginosa.
Angeli, A.; Li, M. C.; Dupin, L.; Vergoten, G.; Noel, M.; Madaoui, M.; Wang, S.; Meyer, A.; Gehin, T.; Vidal, S.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
ChemBioChem 2017, 18 (11), 1036-1047. https://10.1002/cbic.201700154.
162. Glycoclusters with Additional Functionalities for Binding to the LecA Lectin from Pseudomonas aeruginosa.
Angeli, A.; Dupin, L.; Madaoui, M.; Li, M. C.; Vergoten, G.; Wang, S.; Meyer, A.; Gehin, T.; Vidal, S.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
ChemistrySelect 2017, 2 (32), 10420-10427. https://10.1002/slct.201702131.
161. Toward the Rational Design of Galactosylated Glycoclusters That Target Pseudomonas aeruginosa Lectin A (LecA): Influence of Linker Arms That Lead to Low-Nanomolar Multivalent Ligands.
Wang, S.; Dupin, L.; Noel, M.; Carroux, C. J.; Renaud, L.; Gehin, T.; Meyer, A.; Souteyrand, E.; Vasseur, J. J.; Vergoten, G.; Chevolot, Y.; Morvan, F.; Vidal, S.
Chem. Eur. J. 2016, 22 (33), 11785-11794. https://10.1002/chem.201602047.
160. Detection of short ssDNA and dsDNA by current-voltage measurements using conical nanopores coated with Al2O3 by atomic layer deposition.
Thangaraj, V.; Lepoitevin, M.; Smietana, M.; Balanzat, E.; Bechelany, M.; Janot, J. M.; Vasseur, J. J.; Subramanian, S.; Balme, S.
Microchim. Acta 2016, 183 (3), 1011-1017. https://10.1007/s00604-015-1706-2.
159. RNase H-Assisted Imaging of Peroxynitrite in Living Cells with 5 ‘-Boronic Acid Modified DNA.
Reverte, M.; Vaissiere, A.; Boisguerin, P.; Vasseur, J. J.; Smietana, M.
ACS Sens. 2016, 1 (8), 970-974. https://10.1021/acssensors.6b00401.
158. Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA.
Duchemin, N.; Benedetti, E.; Bethge, L.; Vonhoff, S.; Klussmann, S.; Vasseur, J. J.; Cossy, J.; Smietana, M.; Arseniyadis, S.
Chem. Commun. 2016, 52 (55), 8604-8607. https://10.1039/c6cc03540j.
157. A versatile post-synthetic method on a solid support for the synthesis of RNA containing reduction-responsive modifications.
Biscans, A.; Rouanet, S.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Org. Biomol. Chem. 2016, 14 (29), 7010-7017. https://10.1039/c6ob01272h.
156. Lipophilic 2-O-Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery.
Biscans, A.; Bertrand, J. R.; Dubois, J.; Ruger, J.; Vasseur, J. J.; Sczakiel, G.; Dupouy, C.; Debart, F.
ChemBioChem 2016, 17 (21), 2054-2062. https://10.1002/cbic.201600317.
155. Design, Synthesis, and Binding Affinity Evaluation of Hoechst 33258 Derivatives for the Development of Sequence-Specific DNA-Based Asymmetric Catalysts.
Amirbekyan, K.; Duchemin, N.; Benedetti, E.; Joseph, R.; Colon, A.; Markarian, S. A.; Bethge, L.; Vonhoff, S.; Klussmann, S.; Cossy, J.; Vasseur, J. J.; Arseniyadis, S.; Smietana, M.
ACS Catal. 2016, 6 (5), 3096-3105. https://10.1021/acscatal.6b00495.
154. Solid-Phase Synthesis of Oligonucleotide 5 ‘-(alpha-P-Thio)triphosphates and 5 ‘-(alpha-P-Thio)(beta,gamma-methylene)triphosphates.
Thillier, Y.; Sallamand, C.; Baraguey, C.; Vasseur, J. J.; Debart, F.
Eur. J. Org. Chem. 2015, 2015 (2), 302-308. https://10.1002/ejoc.201403381.
153. Nuclease stability of boron-modified nucleic acids: application to label-free mismatch detection.
Reverte, M.; Vasseur, J. J.; Smietana, M.
Org. Biomol. Chem. 2015, 13 (43), 10604-10608. https://10.1039/c5ob01815c.
152. X-ray structure and activities of an essential Mononegavirales L-protein domain.
Paesen, G. C.; Collet, A.; Sallamand, C.; Debart, F.; Vasseur, J. J.; Canard, B.; Decroly, E.; Grimes, J. M.
Nat. Commun. 2015, 6, 10. https://10.1038/ncomms9749.
151. Synthesis and structural characterization of monomeric and dimeric peptide nucleic acids prepared by using microwave-promoted multicomponent reactions.
Ovadia, R.; Lebrun, A.; Barvik, I.; Vasseur, J. J.; Baraguey, C.; Alvarez, K.
Org. Biomol. Chem. 2015, 13 (45), 11052-11071. https://10.1039/c5ob01604e.
150. Hetero-Click Conjugation of Oligonucleotides with Glycosides Using Bifunctional Phosphoramidites.
Meyer, A.; Noel, M.; Vasseur, J. J.; Morvan, F.
Eur. J. Org. Chem. 2015, 2015 (13), 2921-2927. https://10.1002/ejoc.201500165.
149. Mannose-centered aromatic galactoclusters inhibit the biofilm formation of Pseudomonas aeruginosa.
Ligeour, C.; Vidal, O.; Dupin, L.; Casoni, F.; Gillon, E.; Meyer, A.; Vidal, S.; Vergoten, G.; Lacroix, J. M.; Souteyrand, E.; Imberty, A.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Org. Biomol. Chem. 2015, 13 (31), 8433-8444. https://10.1039/c5ob00948k.
148. Importance of topology for glycocluster binding to Pseudomonas aeruginosa and Burkholderia ambifaria bacterial lectins.
Ligeour, C.; Dupin, L.; Angeli, A.; Vergoten, G.; Vidal, S.; Meyer, A.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Org. Biomol. Chem. 2015, 13 (46), 11244-11254. https://10.1039/c5ob01445j.
147. mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research.
Li, C. Q.; Guillen, J.; Rabah, N.; Blanjoie, A.; Debart, F.; Vasseur, J. J.; Canard, B.; Decroly, E.; Coutard, B.
J. Virol. 2015, 89 (16), 8292-8303. https://10.1128/jvi.00599-15.
146. Assessment of the Full Compatibility of Copper(I)-Catalyzed Alkyne-Azide Cycloaddition and Oxime Click Reactions for bis-Labelling of Oligonucleotides.
Estalayo-Adrian, S.; Lartia, R.; Meyer, A.; Vasseur, J. J.; Morvan, F.; Defrancq, E.
ChemistryOpen 2015, 4 (2), 169-173. https://10.1002/open.201402099.
145. Effects of the Surface Densities of Glycoclusters on the Determination of Their IC50 and K-d Value Determination by Using a Microarray.
Dupin, L.; Zuttion, F.; Gehin, T.; Meyer, A.; Phaner-Goutorbe, M.; Vasseur, J. J.; Souteyrand, E.; Morvan, F.; Chevolot, Y.
ChemBioChem 2015, 16 (16), 2329-2336. https://10.1002/cbic.201500371.
144. Synthesis, binding, nuclease resistance and cellular uptake properties of 2 ‘-O-acetalester-modified oligonucleotides containing cationic groups.
Biscans, A.; Rouanet, S.; Bertrand, J. R.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Bioorg. Med. Chem. 2015, 23 (17), 5360-5368. https://10.1016/j.bmc.2015.07.054.
143. DNA-cellulose: an economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis.
Benedetti, E.; Duchemin, N.; Bethge, L.; Vonhoff, S.; Klussmann, S.; Vasseur, J. J.; Cossy, J.; Smietana, M.; Arseniyadis, S.
Chem. Commun. 2015, 51 (28), 6076-6079. https://10.1039/c4cc10190a.
142. Chemical Biology of Nucleic Acids.
Barciszewski, J.; Marquez, V. E.; Vasseur, J. J.; Markiewicz, W. T.
ACS Chem. Biol. 2015, 10 (6), 1358-1361. https://10.1021/acschembio.5b00320.
141. pH-controlled DNA- and RNA-templated assembly of short oligomers.
Barbeyron, R.; Vasseur, J. J.; Smietana, M.
Chem. Sci. 2015, 6 (1), 542-547. https://10.1039/c4sc03028a.
140. DNA-templated borononucleic acid self assembly: a study of minimal complexity.
Barbeyron, R.; Martin, A. R.; Vasseur, J. J.; Smietana, M.
RSC Adv. 2015, 5 (128), 105587-105591. https://10.1039/c5ra20767c.
139. Synthesis of Galactoclusters by Metal-Free Thiol “Click Chemistry” and Their Binding Affinities for Pseudomonas aeruginosa Lectin LecA.
Ligeour, C.; Dupin, L.; Marra, A.; Vergoten, G.; Meyer, A.; Dondoni, A.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Eur. J. Org. Chem. 2014, 2014 (34), 7621-7630. https://10.1002/ejoc.201402902.
138. Structure Binding Relationship of Galactosylated Glycoclusters toward Pseudomonas aeruginosa Lectin LecA Using a DNA-Based Carbohydrate Microarray.
Gerland, B.; Goudot, A.; Ligeour, C.; Pourceau, G.; Meyer, A.; Vidal, S.; Gehin, T.; Vidal, O.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Bioconjugate Chem. 2014, 25 (2), 379-392. https://10.1021/bc4005365.
137. Ecological catalysis and phytoextraction: Symbiosis for future.
Escande, V.; Garoux, L.; Grison, C.; Thillier, Y.; Debart, F.; Vasseur, J. J.; Boulanger, C.; Grison, C.
Appl. Cat. B 2014, 146, 279-288. https://10.1016/j.apcatb.2013.04.011.
136. Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents.
Elayadi, H.; Smietana, M.; Vasseur, J. J.; Balzarini, J.; Lazrek, H. B.
Arch. Pharm. 2014, 347 (2), 134-141. https://10.1002/ardp.201300260.
135. DNA directed immobilization glycocluster array: applications and perspectives.
Chevolot, Y.; Laurenceau, E.; Phaner-Goutorbe, M.; Monnier, V.; Souteyrand, E.; Meyer, A.; Gehin, T.; Vasseur, J. J.; Morvan, F.
Curr. Opin. Chem. Biol. 2014, 18, 46-54. https://10.1016/j.cbpa.2013.12.009.
134. The influence of the aromatic aglycon of galactoclusters on the binding of LecA: a case study with O-phenyl, S-phenyl, O-benzyl, S-benzyl, O-biphenyl and O-naphthyl aglycons.
Casoni, F.; Dupin, L.; Vergoten, G.; Meyer, A.; Ligeour, C.; Gehin, T.; Vidal, O.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Org. Biomol. Chem. 2014, 12 (45), 9166-9179. https://10.1039/c4ob01599a.
133. Synthesis of New Lipoic Acid Conjugates and Evaluation of Their Free Radical Scavenging and Neuroprotective Activities.
Bolognesi, M. L.; Bergamini, C.; Fato, R.; Oiry, J.; Vasseur, J. J.; Smietana, M.
Chem. Biol. Drug Des. 2014, 83 (6), 688-696. https://10.1111/cbdd.12282.
132. Direct Synthesis of Partially Modified 2 ‘-O-Pivaloyloxymethyl RNAs by a Base-Labile Protecting Group Strategy and their Potential for Prodrug-Based Gene-Silencing Applications.
Biscans, A.; Bos, M.; Martin, A. R.; Ader, N.; Sczakiel, G.; Vasseur, J. J.; Dupouy, C.; Debart, F.
ChemBioChem 2014, 15 (18), 2674-2679. https://10.1002/cbic.201402382.
131. Recent developments in alkyne borylations.
Barbeyron, R.; Benedetti, E.; Cossy, J.; Vasseur, J. J.; Arseniyadis, S.; Smietana, M.
Tetrahedron 2014, 70 (45), 8431-8452. https://10.1016/j.tet.2014.06.026.
130. DNA vs. Mirror-Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA-Based Asymmetric Catalysis.
Wang, J.; Benedetti, E.; Bethge, L.; Vonhoff, S.; Klussmann, S.; Vasseur, J. J.; Cossy, J.; Smietana, M.; Arseniyadis, S.
Angew. Chem. Int. Ed. 2013, 52 (44), 11546-11549. https://10.1002/anie.201306232.
129. Solid-phase synthesis of 5′-triphosphate 2′-5′-oligoadenylates analogs with 3′-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.
Thillier, Y.; Stevens, S. K.; Moy, C.; Taylor, J.; Vasseur, J. J.; Beigelman, L.; Debart, F.
Bioorg. Med. Chem. 2013, 21 (17), 5461-5469. https://10.1016/j.bmc.2013.06.008.
128. Metallophyte wastes and polymetallic catalysis: a promising combination in green chemistry. The illustrative synthesis of 5 ‘-capped RNA.
Thillier, Y.; Losfeld, G.; Escande, V.; Dupouy, C.; Vasseur, J. J.; Debart, F.; Grison, C.
RSC Adv. 2013, 3 (15), 5204-5212. https://10.1039/c3ra23115a.
127. Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates.
Piton, J.; Larue, V.; Thillier, Y.; Dorleans, A.; Pellegrini, O.; de la Sierra-Gallay, I. L.; Vasseur, J. J.; Debart, F.; Tisne, C.; Condon, C.
Proc. Natl. Acad. Sci. U. S. A. 2013, 110 (22), 8858-8863. https://10.1073/pnas.1221510110.
126. Synthesis of Monoconjugated and Multiply Conjugated Oligonucleotides by “Click Thiol” Thiol-Michael-Type Additions and by Combination with CuAAC “Click Huisgen”.
Meyer, A.; Vasseur, J. J.; Morvan, F.
Eur. J. Org. Chem. 2013, 2013 (3), 465-473. https://10.1002/ejoc.201201311.
125. Boron and nucleic acid chemistries: merging the best of both worlds.
Martin, A. R.; Vasseur, J. J.; Smietana, M.
Chem. Soc. Rev. 2013, 42 (13), 5684-5713. https://10.1039/c3cs60038f.
124. Synthesis of branched-phosphodiester and mannose-centered fucosylated glycoclusters and their binding studies with Burkholderia ambifaria lectin (BambL).
Ligeour, C.; Audfray, A.; Gillon, E.; Meyer, A.; Galanos, N.; Vidal, S.; Vasseur, J. J.; Imberty, A.; Morvan, F.
RSC Adv. 2013, 3 (42), 19515-19524. https://10.1039/c3ra43807d.
123. Development of Innovative and Versatile Polythiol Probes for Use on ELOSA or Electrochemical Biosensors: Application in Hepatitis C Virus Genotyping.
Lereau, M.; Fournier-Wirth, C.; Mayen, J.; Farre, C.; Meyer, A.; Dugas, V.; Cantaloube, J. F.; Chaix, C.; Vasseur, J. J.; Morvan, F.
Anal. Chem. 2013, 85 (19), 9204-9212. https://10.1021/ac401941x.
122. Quantitative analysis (K-d and IC50) of glycoconjugates interactions with a bacterial lectin on a carbohydrate microarray with DNA Direct Immobilization (DDI).
Goudot, A.; Pourceau, G.; Meyer, A.; Gehin, T.; Vidal, S.; Vasseur, J. J.; Morvan, F.; Souteyrand, E.; Chevolot, Y.
Biosens. Bioelectron. 2013, 40 (1), 153-160. https://10.1016/j.bios.2012.07.003.
121. Fluorescence Enhancement upon G-Quadruplex Folding: Synthesis, Structure, and Biophysical Characterization of a Dansyl/Cyclodextrin-Tagged Thrombin Binding Aptamer.
De Tito, S.; Morvan, F.; Meyer, A.; Vasseur, J. J.; Cummaro, A.; Petraccone, L.; Pagano, B.; Novellino, E.; Randazzo, A.; Giancola, C.; Montesarchio, D.
Bioconjugate Chem. 2013, 24 (11), 1917-1927. https://10.1021/bc400352s.
120. Development of specific dengue virus 2 ‘-O- and N7-methyltransferase assays for antiviral drug screening.
Barral, K.; Sallamand, C.; Petzold, C.; Coutard, B.; Collet, A.; Thillier, Y.; Zimmermann, J.; Vasseur, J. J.; Canard, B.; Rohayem, J.; Debart, F.; Decroly, E.
Antiviral Res. 2013, 99 (3), 292-300. https://10.1016/j.antiviral.2013.06.001.
119. Boronic acid-based autoligation of nucleic acids: influence of the nature of the 3 ‘-end ribonucleotidic strand.
Barbeyron, R.; Wengel, J.; Vasseur, J. J.; Smietana, M.
Mon. Chem. 2013, 144 (4), 495-500. https://10.1007/s00706-012-0881-7.
118. The biolabile 2 ‘-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure.
Baraguey, C.; Lescrinier, E.; Lavergne, T.; Debart, F.; Herdewijn, P.; Vasseur, J. J.
Org. Biomol. Chem. 2013, 11 (16), 2638-2647. https://10.1039/c3ob27005j.
117. Synthesis of 5 ‘ cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N-7)-methyl transferase.
Thillier, Y.; Decroly, E.; Morvan, F.; Canard, B.; Vasseur, J. J.; Debart, F.
RNA 2012, 18 (4), 856-868. https://10.1261/rna.030932.111.
116. Dynamic boronic acid-mediated autoligation of DNA strands.
Smietana, M.; Martin, A. R.; Vasseur, J. J.
Pure Appl. Chem. 2012, 84 (7), 1659-1667. https://10.1351/pac-con-11-09-28.
115. Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome.
Selisko, B.; Potisopon, S.; Agred, R.; Priet, S.; Varlet, I.; Thillier, Y.; Sallamand, C.; Debart, F.; Vasseur, J. J.; Canard, B.
PLoS Pathog. 2012, 8 (9), 13. https://10.1371/journal.ppat.1002912.
114. DNA glycoclusters and DNA-based carbohydrate microarrays: From design to applications.
Morvan, F.; Vidal, S.; Souteyrand, E.; Chevolot, Y.; Vasseur, J. J.
RSC Adv. 2012, 2 (32), 12043-12068. https://10.1039/c2ra21550k.
113. Bis- and Tris-Alkyne Phosphoramidites for Multiple 5′-Labeling of Oligonucleotides by Click Chemistry.
Ligeour, C.; Meyer, A.; Vasseur, J. J.; Morvan, F.
Eur. J. Org. Chem. 2012, 2012 (9), 1851-1856. https://10.1002/ejoc.201101763.
112. Synthesis of Homo- and Heterofunctionalized Glycoclusters and Binding to Pseudomonas aeruginosa Lectins PA-IL and PA-IIL.
Gerland, B.; Goudot, A.; Pourceau, G.; Meyer, A.; Vidal, S.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
J. Org. Chem. 2012, 77 (17), 7620-7626. https://10.1021/jo300826u.
111. Synthesis of a Library of Fucosylated Glycoclusters and Determination of their Binding toward Pseudomonas aeruginosa Lectin B (PA-IIL) Using a DNA-Based Carbohydrate Microarray.
Gerland, B.; Goudot, A.; Pourceau, G.; Meyer, A.; Dugas, V.; Cecioni, S.; Vidal, S.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Bioconjugate Chem. 2012, 23 (8), 1534-1547. https://10.1021/bc2006434.
110. Preparation of 1,4-disubstituted-1,2,3-triazolo ribonucleosides by Na2CuP2O7 catalyzed azide-alkyne 1,3-dipolar cycloaddition.
Elayadi, H.; Mesnaoui, M.; Korba, B. E.; Smietana, M.; Vasseur, J. J.; Secrist, J. A.; Lazrek, H. B.
Arkivoc 2012, 76-89. https://10.3998/ark.5550190.0013.807.
109. Borononucleotides as Substrates/Binders for Human NMP Kinases: Enzymatic and Spectroscopic Evaluation.
El Amri, C.; Martin, A. R.; Vasseur, J. J.; Smietana, M.
ChemBioChem 2012, 13 (11), 1605-1612. https://10.1002/cbic.201200199.
108. An innovative strategy for sulfopeptides analysis using MALDI-TOF MS reflectron positive ion mode.
Cantel, S.; Brunel, L.; Ohara, K.; Enjalbal, C.; Martinez, J.; Vasseur, J. J.; Smietana, M.
Proteomics 2012, 12 (14), 2247-2257. https://10.1002/pmic.201100525.
107. Measurement of Enzymatic Activity and Specificity of Human and Avian Influenza Neuraminidases from Whole Virus by Glycoarray and MALDI-TOF Mass Spectrometry.
Pourceau, G.; Chevolot, Y.; Goudot, A.; Giroux, F.; Meyer, A.; Moules, V.; Lina, B.; Cecioni, S.; Vidal, B.; Yu, H.; Chen, X.; Ferraris, O.; Praly, J. P.; Souteyrand, E.; Vasseur, J. J.; Morvan, F.
ChemBioChem 2011, 12 (13), 2071-2080. https://10.1002/cbic.201100128.
106. Regioselective Synthesis of 3-Carbo-5-phosphonylpyrazoles through a One-Pot Claisen-Schmidt/1,3-Dipolar Cycloaddition/Oxidation Sequence.
Martin, A. R.; Mohanan, K.; Toupet, L.; Vasseur, J. J.; Smietana, M.
Eur. J. Org. Chem. 2011, 2011 (17), 3184-3190. https://10.1002/ejoc.201100167.
105. Dynamic and Programmable DNA-Templated Boronic Ester Formation.
Martin, A. R.; Barvik, I.; Luvino, D.; Smietana, M.; Vasseur, J. J.
Angew. Chem. Inter. Ed. 2011, 50 (18), 4193-4196. https://10.1002/anie.201007170.
104. Synthesis and Preliminary Evaluation of pro-RNA 2 ‘-O-Masked with Biolabile Pivaloyloxymethyl Groups in an RNA Interference Assay.
Lavergne, T.; Baraguey, C.; Dupouy, C.; Parey, N.; Wuensche, W.; Sczakiel, G.; Vasseur, J. J.; Debart, F.
J. Org. Chem. 2011, 76 (14), 5719-5731. https://10.1021/jo200826h.
103. Multiplexed binding determination of seven glycoconjugates for Pseudomonas aeruginosa Lectin I (PA-IL) using a DNA-based carbohydrate microarray.
Chevolot, Y.; Zhang, J.; Meyer, A.; Goudot, A.; Rouanet, S.; Vidal, S.; Pourceau, G.; Cloarec, J. P.; Praly, J. P.; Souteyrand, E.; Vasseur, J. J.; Morvan, F.
Chem. Commun. 2011, 47 (31), 8826-8828. https://10.1039/c1cc12428e.
102. Electrochemical detection of nucleic acids using pentaferrocenyl phosphoramidate alpha-oligonucleotides.
Chatelain, G.; Meyer, A.; Morvan, F.; Vasseur, J. J.; Chaix, C.
New J. Chem. 2011, 35 (4), 893-901. https://10.1039/c0nj00902d.
101. Efficient Solid-Phase Chemical Synthesis of 5 ‘-Triphosphates of DNA, RNA, and their Analogues.
Zlatev, I.; Lavergne, T.; Debart, F.; Vasseur, J. J.; Manoharan, M.; Morvan, F.
Org. Lett. 2010, 12 (10), 2190-2193. https://10.1021/ol1004214.
100. 3 ‘-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity.
Priet, S.; Zlatev, I.; Barvik, I.; Geerts, K.; Leyssen, P.; Neyts, J.; Dutartre, H.; Canard, B.; Vasseur, J. J.; Morvan, F.; Alvarez, K.
J. Med. Chem. 2010, 53 (18), 6608-6617. https://10.1021/jm100102v.
99. Oligonucleotide Carbohydrate-Centered Galactosyl Cluster Conjugates Synthesized by Click and Phosphoramidite Chemistries.
Pourceau, G.; Meyer, A.; Chevolot, Y.; Souteyrand, E.; Vasseur, J. J.; Morvan, F.
Bioconjugate Chem. 2010, 21 (8), 1520-1529. https://10.1021/bc1001888.
98. From Anionic to Cationic alpha-Anomeric Oligodeoxynucleotides.
Morvan, F.; Debart, F.; Vasseur, J. J.
Chem. Biodivers. 2010, 7 (3), 494-535. https://10.1002/cbdv.200900220.
97. Three-Component Reaction Using the Bestmann-Ohira Reagent: A Regioselective Synthesis of Phosphonyl Pyrazole Rings.
Mohanan, K.; Martin, A. R.; Toupet, L.; Smietana, M.; Vasseur, J. J.
Angew. Chem. Int. Ed. 2010, 49 (18), 3196-3199. https://10.1002/anie.200906781.
96. Oligonucleotide Sequential Bis-Conjugation via Click-Oxime and Click-Huisgen Procedures.
Meyer, A.; Spinelli, N.; Dumy, P.; Vasseur, J. J.; Morvan, F.; Defrancq, E.
J. Org. Chem. 2010, 75 (11), 3927-3930. https://10.1021/jo.100599m.
95. 5 ‘-Bis-conjugation of Oligonucleotides by Amidative Oxidation and Click Chemistry.
Meyer, A.; Pourceau, G.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2010, 75 (19), 6689-6692. https://10.1021/jo101134z.
94. Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors.
Elayadi, H.; Smietana, M.; Pannecouque, C.; Leyssen, P.; Neyts, J.; Vasseur, J. J.; Lazrek, H. B.
Bioorg. Med. Chem. Lett. 2010, 20 (24), 7365-7368. https://10.1016/j.bmcl.2010.10.046.
93. A Procedure for Facile Synthesis of Nucleosides Using N, O-Bistrimethylsilylacetamide in the Presence of Natural Phosphate Coated with Potassium Iodide.
Baddi, L.; Smietana, M.; Sebti, S.; Vasseur, J. J.; Lazrek, H. B.
Lett. Org. Chem. 2010, 7 (3), 196-199. https://10.2174/157017810791112441.
92. delta-Di-carboxybutyl phosphoramidate of 2 ‘-deoxycytidine-5 ‘-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase.
Zlatev, I.; Giraut, A.; Morvan, F.; Herdewijn, P.; Vasseur, J. J.
Bioorg. Med. Chem. 2009, 17 (19), 7008-7014. https://10.1016/j.bmc.2009.08.001.
91. Specific recognition of lectins by oligonucleotide glycoconjugates and sorting on a DNA microarray.
Zhang, J.; Pourceau, G.; Meyer, A.; Vidal, S.; Praly, J. P.; Souteyrand, E.; Vasseur, J. J.; Morvan, F.; Chevolot, Y.
Chem. Commun. 2009, (44), 6795-6797. https://10.1039/b915132j.
90. DNA-directed immobilisation of glycomimetics for glycoarrays application: Comparison with covalent immobilisation, and development of an on-chip IC50 measurement assay.
Zhang, J.; Pourceau, G.; Meyer, A.; Vidal, S.; Praly, J. P.; Souteyrand, E.; Vasseur, J. J.; Morvan, F.; Chevolot, Y.
Biosens. Bioelectron. 2009, 24 (8), 2515-2521. https://10.1016/j.bios.2009.01.007.
89. Synthesis of Mannose and Galactose Oligonucleotide Conjugates by Bi-click chemistry.
Pourceau, G.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2009, 74 (3), 1218-1222. https://10.1021/jo802536q.
88. Azide Solid Support for 3 ‘-Conjugation of Oligonucleotides and Their Circularization by Click Chemistry.
Pourceau, G.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2009, 74 (17), 6837-6842. https://10.1021/jo9014563.
87. NIS-promoted guanylation of amines.
Ohara, K.; Vasseur, J. J.; Smietana, M.
Tetrahedron Lett. 2009, 50 (13), 1463-1465. https://10.1016/j.tetlet.2009.01.073.
86. Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Analysis of Polysulfated-Derived Oligosaccharides Using Pyrenemethylguanidine.
Ohara, K.; Jacquinet, J. C.; Jouanneau, D.; Helbert, W.; Smietana, M.; Vasseur, J. J.
J. Am. Soc. Mass Spectrom. 2009, 20 (1), 131-137. https://10.1016/j.jasms.2008.09.004.
85. Design of Triazole-Tethered Glycoclusters Exhibiting Three Different Spatial Arrangements and Comparative Study of their Affinities towards PA-IL and RCA 120 by Using a DNA-Based Glycoarray.
Moni, L.; Pourceau, G.; Zhang, J.; Meyer, A.; Vidal, S.; Souteyrand, E.; Dondoni, A.; Morvan, F.; Chevolot, Y.; Vasseur, J. J.; Marra, A.
ChemBioChem 2009, 10 (8), 1369-1378. https://10.1002/cbic.200900024.
84. Expanding the borononucleotide family: synthesis of borono-analogues of dCMP, dGMP and dAMP.
Martin, A. R.; Mohanan, K.; Luvino, D.; Floquet, N.; Baraguey, C.; Smietana, M.; Vasseur, J. J.
Org. Biomol. Chem. 2009, 7 (21), 4369-4377. https://10.1039/b912616c.
83. Assessment of new 2 ‘-O-acetalester protecting groups for regular RNA synthesis and original
2′-modified proRNA.
Martin, A. R.; Lavergne, T.; Vasseur, J. J.; Debart, F.
Bioorg. Med. Chem. Lett. 2009, 19 (15), 4046-4049. https://10.1016/j.bmcl.2009.06.015.
82. Efficient Release of Base-Sensitive Oligonucleotides from Solid Supports using Fluoride Ions.
Lavergne, T.; Parey, N.; Vasseur, J. J.; Debart, F.
Eur. J. Org. Chem. 2009, 2009 (13), 2190-2194. https://10.1002/ejoc.200801275.
81. Deoxygenation of 5-O-benzoyl-1,2-isopropylidene-3-O-imidazolylthiocarbonyl-alpha-D-xylofu ranose using dimethyl phosphite: an efficient alternate method towards a 3′-deoxynucleoside glycosyl donor.
Zlatev, I.; Vasseur, J. J.; Morvan, F. O.
Tetrahedron Lett. 2008, 49 (20), 3288-3290. https://10.1016/j.tetlet.2008.03.079.
80. Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors.
Zlatev, I.; Dutartre, H.; Barvik, I.; Neyts, J.; Canard, B.; Vasseur, J. J.; Alvarez, K.; Morvan, F.
J. Med. Chem. 2008, 51 (18), 5745-5757. https://10.1021/jm800617c.
79. Synthesis of new N-isobutyryl-L-cysteine/MEA conjugates: Evaluation of their free radical-scavenging activities and anti-HIV properties in human macrophages.
Smietana, M.; Clayette, P.; Mialocq, P.; Vasseur, J. J.; Oiry, J.
Bioorganic Chem. 2008, 36 (1-3), 133-140. https://10.1016/j.bioorg.2008.02.001.
78. Combinatorial and automated synthesis of phosphodiester galactosyl cluster on solid support by click chemistry assisted by microwaves.
Pourceau, G.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2008, 73 (15), 6014-6017. https://10.1021/jo8009837.
77. Incorporation of oxidized guanine nucleoside 5 ‘-triphosphates in DNA with DNA polymerases and preparation of single-lesion carrying DNA.
Mourgues, S.; Trzcionka, J.; Vasseur, J. J.; Pratviel, G.; Meunier, B.
Biochemistry 2008, 47 (16), 4788-4799. https://10.1021/bi7022199.
76. Boronic acid-based fluorescent receptors for selective recognition of thymine glycol.
Luvino, D.; Gasparutto, D.; Reynaud, S.; Smietana, M.; Vasseur, J. J.
Tetrahedron Lett. 2008, 49 (42), 6075-6078. https://10.1016/j.tetlet.2008.07.173.
75. Borononucleotides: synthesis, and formation of a new reversible boronate internucleosidic linkage.
Luvino, D.; Baraguey, C.; Smietana, M.; Vasseur, J. J.
Chem. Commun. 2008, (20), 2352-2354. https://10.1039/b802098a.
74. New strategies for cyclization and bicyclization of oligonucleotides by click chemistry assisted by microwaves.
Lietard, J.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2008, 73 (1), 191-200. https://10.1021/jo702177c.
73. A Base-Labile Group for 2 ‘-OH Protection of Ribonucleosides: A Major Challenge for RNA Synthesis.
Lavergne, T.; Bertrand, J. R.; Vasseur, J. J.; Debart, F.
Chem. Eur. J. 2008, 14 (30), 9135-9138. https://10.1002/chem.200801392.
72. Convenient synthesis of N-2-isobutyryl-2′-O-methyl guanosine by efficient alkylation of O-6-trimethylsilylethyl-3′,5′-di-tert-butylsilanediyl guanosine.
Zlatev, I.; Vasseur, J. J.; Morvan, F.
Tetrahedron 2007, 63 (45), 11174-11178. https://10.1016/j.tet.2007.08.006.
71. High-yield production of short GpppA- and (7Me)GpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2 ‘ O positions.
Peyrane, F.; Selisko, B.; Decroly, E.; Vasseur, J. J.; Benarroch, D.; Canard, B.; Alvarez, K.
Nucleic Acids Res. 2007, 35 (4), 11. https://10.1093/nar/gkl1119.
70. Amine-guanidine switch: A promising approach to improve DNA binding and antiproliferative activities.
Ohara, K.; Smietana, M.; Restouin, A.; Mollard, S.; Borg, J. P.; Collette, Y.; Vasseur, J. J.
J. Med. Chem. 2007, 50 (26), 6465-6475. https://10.1021/jm701207m.
69. Synthesis and biological evaluation of some alpha- 6-(1 ‘-carbamoylalkylthio)-1H-pyrazolo 3,4-D pyrimidin-4-yl thioalkylcarboxam ide acyclonucleosides.
Moukha-Chafiq, O.; Taha, M. L.; Mouna, A.; Lazrek, H. B.; Vasseur, J. J.
Nucleosides Nucleotides Nucleic Acids 2007, 26 (4), 335-345. https://10.1080/15257770701296952.
68. Fucosylated pentaerythrityl phosphodiester oligomers (PePOs): Automated synthesis of DNA-Based glycoclusters and binding to Pseudomonas aeruginosa lectin (PA-IIL).
Morvan, F.; Meyer, A.; Jochum, A.; Sabin, C.; Chevolot, Y.; Imberty, A.; Praly, J. P.; Vasseur, J. J.; Souteyrand, E.; Vidal, S.
Bioconjugate Chem. 2007, 18 (5), 1637-1643. https://10.1021/bc070129z.
67. Sequential Seyferth-Gilbert/CuAAC reactions: Application to the one-pot synthesis of triazoles from aldehydes.
Luvino, D.; Amalric, C.; Smietana, M.; Vasseur, J. J.
Synlett 2007, (19), 3037-3041. https://10.1055/s-2007-990877.
66. An efficient reagent for 5 ‘-azido oligonucleotide synthesis.
Lietard, J.; Meyer, A.; Vasseur, J. J.; Morvan, F.
Tetrahedron Lett. 2007, 48 (50), 8795-8798. https://10.1016/j.tetlet.2007.10.081.
65. Conformational and chiral selection of oligonucleotides.
Froeyen, M.; Morvan, F.; Vasseur, J. J.; Nielsen, P.; Van Aerschot, A.; Rosemeyer, H.; Herdewijn, P.
Chem. Biodivers. 2007, 4 (4), 803-817. https://10.1002/cbdv.200790065.
64. 5-Propynylamino alpha-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic alpha-oligonucleotides.
Deglane, G.; Morvan, F.; Debart, F.; Vasseur, J. J.
Bioorg. Med. Chem. Lett. 2007, 17 (4), 951-954. https://10.1016/j.bmcl.2006.11.052.
63. Chemical modifications to improve the cellular uptake of oligonucleotides.
Debart, F.; Abes, S.; Deglane, G.; Moulton, H. M.; Clair, P.; Gait, M. J.; Vasseur, J. J.; Lebleu, B.
Curr. Top. Med. Chem. 2007, 7 (7), 727-737. https://10.2174/156802607780487704.
62. DNA-based carbohydrate biochips: A platform for surface glyco-engineering.
Chevolot, Y.; Bouillon, C.; Vidal, S.; Morvan, F.; Meyer, A.; Cloarec, J. P.; Jochum, A.; Praly, J. P.; Vasseur, J. J.; Souteyrand, E.
Angew. Chem. Int. Ed. 2007, 46 (14), 2398-2402. https://10.1002/anie.200604955.
61. Use of a solid-supported coupling reagent for a selective phosphitylation of the primary alcohol of N-2-isobutyryl-2 ‘-deoxy or 2 ‘-O-methyl guanosine.
Zlatev, I.; Kato, Y.; Meyer, A.; Vasseur, J. J.; Morvan, F.
Tetrahedron Lett. 2006, 47 (47), 8379-8382. https://10.1016/j.tetlet.2006.09.086.
60. First evaluation of acyloxymethyl or acylthiomethyl groups as biolabile 2 ‘-O-protections of RNA.
Parey, N.; Baraguey, C.; Vasseur, J. J.; Debart, F.
Org. Lett. 2006, 8 (17), 3869-3872. https://10.1021/ol0616182.
59. Characterization of specific noncovalent complexes between guanidinium derivatives and single-stranded DNA by MALDI.
Ohara, K.; Smietana, M.; Vasseur, J. J.
J. Am. Soc. Mass Spectrom. 2006, 17 (3), 283-291. https://10.1016/j.jasms.2005.11.005.
58. Synthesis and antiviral activity of some C-2-, C-4-, and C-6-substituted pyrazolo 3,4-D pyrimidine acyclonucleosides with the alkylating chains of ACV, HBG, and ISO-DHPG.
Moukha-chafiq, O.; Taha, M. L.; Lazrek, H. B.; Vasseur, J. J.; De Clercq, E.
Nucleosides Nucleotides Nucleic Acids 2006, 25 (8), 849-860. https://10.1080/15257770600793802.
57. A versatile reagent for the synthesis of 5 ‘-phosphorylated, 5 ‘-thiophosphorylated or 5 ‘-phosphoramidate-conjugated oligonucleotides.
Meyer, A.; Bouillon, C.; Vidal, S.; Vasseur, J. J.; Morvan, F.
Tetrahedron Lett. 2006, 47 (50), 8867-8871. https://10.1016/j.tetlet.2006.10.049.
56. Selective fluorescence-based detection of dihydrouridine with boronic acids.
Luvino, D.; Smietana, M.; Vasseur, J. J.
Tetrahedron Lett. 2006, 47 (52), 9253-9256. https://10.1016/j.tetlet.2006.10.150.
55. A one-pot synthesis of D-ribonucleosides using natural phosphate doped with KI in HMDS.
Lazrek, H. B.; Ouzebla, D.; Rochdi, A.; Redwane, N.; Vasseur, J. J.
Lett. Org. Chem. 2006, 3 (4), 313-314. https://10.2174/157017806776114531.
54. Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding – Role of DNA backbone flexibility and an open catalytic site.
Johnson, A. A.; Sayer, J. M.; Yagi, H.; Patil, S. S.; Debart, F.; Maier, M. A.; Corey, D. R.; Vasseur, J. J.; Burke, T. R.; Marquez, V. E.; Jerina, D. M.; Pommier, Y.
J. Biol. Chem. 2006, 281 (43), 32428-32438. https://10.1074/jbc.M605101200.
53. Impact of the guanidinium group on hybridization and cellular uptake of cationic oligonucleotides.
Deglane, G.; Abes, S.; Michel, T.; Prevot, P.; Vives, E.; Debart, F.; Barvik, I.; Lebleu, B.; Vasseur, J. J.
ChemBioChem 2006, 7 (4), 684-692. https://10.1002/cbic.200500433.
52. Microwave assisted “click” chemistry for the synthesis of multiple labeled-carbohydrate oligonucleotides on solid support.
Bouillon, C.; Meyer, A.; Vidal, S.; Jochum, A.; Chevolot, Y.; Cloarec, J. P.; Praly, J. P.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2006, 71 (12), 4700-4702. https://10.1021/jo060572n.
51. Solution-phase synthesis of phosphorothioate oligonucleotides using a solid-supported acyl chloride with H-phosphonate chemistry.
Adamo, I.; Dueymes, U.; Schonberger, A.; Navarro, A. E.; Meyer, A.; Lange, M.; Imbach, J. L.; Link, F.; Morvan, F.; Vasseur, J. J.
Eur. J. Org. Chem. 2006, 2006 (2), 436-448. https://10.1002/ejoc.200500547.
50. Highly stable DNA triplexes formed with cationic phosphoramidate pyrimidine alpha-oligonucleotides.
Michel, T.; Debart, F.; Heitz, F.; Vasseur, J. J.
ChemBioChem 2005, 6 (7), 1254-1262. https://10.1002/cbic.200400436.
49. Toward high yield synthesis of peptide-oligonucleotide chimera through a disulfide bridge: A simplified method for oligonucleotide activation.
Maurel, F.; Debart, F.; Cavelier, F.; Thierry, A. R.; Lebleu, B.; Vasseur, J. J.; Vives, E.
Bioorg. Med. Chem. Lett. 2005, 15 (22), 5084-5087. https://10.1016/j.bmcl.2005.07.086.
48. Optimized synthesis of functionalized fluorescent oligodeoxynucleotides for protein labeling.
Goussu, C.; Vasseur, J. J.; Bazin, H.; Trinquet, E.; Maurin, F.; Morvan, F.
Bioconjugate Chem. 2005, 16 (2), 465-470. https://10.1021/bc049752z.
47. Universal solid supports for the synthesis of oligonucleotides via a transesterification of H-phosphonate diester linkage.
Ferreira, F.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2005, 70 (23), 9198-9206. https://10.1021/jo051172n.
46. High-yield solution-phase synthesis of Di- and trinucleotide blocks assisted by polymer-supported reagents.
Dueymes, C.; Schonberger, A.; Adamo, I.; Navarro, A. E.; Meyer, A.; Lange, M.; Imbach, J. L.; Link, F.; Morvan, F.; Vasseur, J. J.
Org. Lett. 2005, 7 (16), 3485-3488. https://10.1021/ol0511777.
45. Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity.
Taourirte, M.; Mohamed, L. A.; Rochdi, A.; Vasseur, J. J.; Fernandez, S.; Ferrero, M.; Gotor, V.; Pannecouque, C.; De Clercq, E.; Lazrek, H. B.
Nucleosides Nucleotides Nucleic Acids 2004, 23 (4), 701-714. https://10.1081/ncn-120037749.
44. H-Phosphonate oligonucleotides from phosphoramidite chemistry.
Meyer, A.; Morvan, F.; Vasseur, J. J.
Tetrahedron Lett. 2004, 45 (19), 3745-3748. https://10.1016/j.tetlet.2004.03.093.
43. Lewis acid deprotection of silyl-protected oligonucleotides and base-sensitive oligonucleotide analogues.
Ferreira, F.; Vasseur, J. J.; Morvan, F.
Tetrahedron Lett. 2004, 45 (33), 6287-6290. https://10.1016/j.tetlet.2004.06.081.
42. Cationic phosphoramidate alpha-oligonucleotides efficiently target single-stranded DNA and RNA and inhibit hepatitis C virus IRES-mediated translation.
Michel, T.; Martinand-Mari, C.; Debart, F.; Lebleu, B.; Robbins, I.; Vasseur, J. J.
Nucleic Acids Res. 2003, 31 (18), 5282-5290. https://10.1093/nar/gkg733.
41. FTIR and UV spectroscopy studies of triplex formation between alpha-oligonucleotides with non-ionic phoshoramidate linkages and DNA targets.
Michel, T.; Debart, F.; Vasseur, J. J.; Geinguenaud, F.; Taillandier, E.
J. Biomol. Struct. Dyn. 2003, 21 (3), 435-445. https://10.1080/07391102.2003.10506938.
40. Efficient guanidination of the phosphate linkage towards cationic phosphoramidate oligonucleotides.
Michel, T.; Debart, F.; Vasseur, J. J.
Tetrahedron Lett. 2003, 44 (35), 6579-6582. https://10.1016/s0040-4039(03)01694-0.
39. FTIR and UV spectroscopy studies of triplex formation between pyrimidine methoxyethylphosphoramidates alpha-oligodeoxynucleotides and ds DNA targets.
Sun, B. W.; Geinguenaud, F.; Taillandier, E.; Naval, M.; Laurent, A.; Debart, F.; Vasseur, J. J.
J. Biomol. Struct. Dyn. 2002, 19 (6), 1073-1081. https://10.1080/07391102.2002.10506810.
38. Use of allylic protecting groups for the synthesis of base-sensitive prooligonucleotides.
Spinelli, N.; Meyer, A.; Hayakawa, Y.; Imbach, J. L.; Vasseur, J. J.
Eur. J. Org. Chem. 2002, 2002 (1), 49-56. https://doi.org/10.1002/1099-0690(20021)2002:1%3C49::AID-EJOC49%3E3.0.CO;2-7.
37. 2-Amino-alpha-2 ‘-deoxyadenosine increased duplex stability of methoxyethylphosphoramidate alpha-oligodeoxynucleotides with RNA target.
Naval, M.; Michel, T.; Vasseur, J. J.; Debart, F.
Bioorg. Med. Chem. Lett. 2002, 12 (11), 1435-1438. https://10.1016/s0960-894x(02)00215-9.
36. Synthesis and biological activity of some 4-substituted 1- 1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4&5)-ylmethyl -1H-py razolo 3,4-d pyrimidines.
Moukha-chafiq, O.; Taha, M. L.; Lazrek, H. B.; Vasseur, J. J.; Pannecouque, C.; Witvrouw, M.; De Clercq, E.
Farmaco 2002, 57 (1), 27-32. https://10.1016/s0014-827x(01)01152-1.
35. Synthesis and biological evaluation of some acyclic alpha-(1H-pyrazolo 3,4-d pyrimidin-4-yl)thioalkylamide nucleosides.
Moukha-Chafiq, O.; Taha, M. L.; Lazrek, H. B.; Vasseur, J. J.; De Clercq, E.
Nucleosides Nucleotides Nucleic Acids 2002, 21 (2), 165-176. https://10.1081/ncn-120003180.
34. Use of MALDI-TOF mass spectrometry to monitor solid-phase synthesis of oligonucleotides.
Guerlavais, T.; Meyer, A.; Debart, F.; Imbach, J. L.; Morvan, F.; Vasseur, J. J.
Anal. Bioanal. Chem. 2002, 374 (1), 57-63. https://10.1007/s00216-002-1395-7.
33. Synthesis and biological evaluation of some 4-substituted 1- 1-(4-hydroxybutyl)-1,2,3-triazol-(4&5)-ylmethyl 1H-pyrazolo- 3,4-d py rimidines.
Moukha-Chafiq, O.; Taha, M. L.; Lazrek, H. B.; Vasseur, J. J.; Pannecouque, C.; Witvrouw, M.; De Clercq, E.
Nucleosides Nucleotides Nucleic Acids 2001, 20 (10-11), 1811-1821. https://10.1081/ncn-100107192.
32. Kinetics study of the biotransformation of an oligonucleotide prodrug in cells extract by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry.
Bres, J. C.; Morvan, F.; Lefebvre, I.; Vasseur, J. J.; Pompon, A.; Imbach, J. L.
J. Chromatogr. B 2001, 753 (1), 123-130. https://10.1016/s0378-4347(00)00502-8.
31. Prooligonucleotides exhibit less serum-protein binding than phosphodiester and phosphorothioate oligonucleotides.
Tosquellas, G.; Bryksin, A.; Alvarez, K.; Morvan, F.; Vasseur, J. J.; Rayner, B.; Rykova, E.; Laktionov, P.; Vlassov, V.; Imbach, J. L.
Nucleosides Nucleotides Nucleic Acids 2000, 19 (5-6), 995-1003. https://10.1080/15257770008033038.
30. Analysis of solid-supported oligonucleotides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Meyer, A.; Spinelli, N.; Imbach, J. L.; Vasseur, J. J.
Rapid Commun. Mass Spectrom. 2000, 14 (4), 234-242. https://10.1002/(sici)1097-0231(20000229)14:4<234::aid-rcm874>3.0.co;2-1.
29. Prooligonucleotide metabolism in a crude cell extract followed by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry.
Lioux, T.; Lefebvre, I.; Vasseur, J. J.; Imbach, J. L.
Rapid Commun. Mass Spectrom. 1999, 13 (16), 1645-1649. https://10.1002/(sici)1097-0231(19990830)13:16<1645::aid-rcm692>3.0.co;2-y.
28. Chiral and steric effects in the efficient binding of alpha-anomeric deoxyoligonucleoside N-alkylphosphoramidates to ssDNA and RNA.
Laurent, A.; Naval, M.; Debart, F.; Vasseur, J. J.; Rayner, B.
Nucleic Acids Res. 1999, 27 (21), 4151-4159. https://10.1093/nar/27.21.4151.
27. Photocleavable protecting groups as nucleobase protections allowed the solid-phase synthesis of base-sensitive SATE-prooligonucleotides.
Alvarez, K.; Vasseur, J. J.; Beltran, T.; Imbach, J. L.
J. Org. Chem. 1999, 64 (17), 6319-6328. https://10.1021/jo990479h.
26. The pro-oligonucleotide approach: solid phase synthesis and preliminary evaluation of model pro-dodecathymidylates.
Tosquellas, G.; Alvarez, K.; Dell’Aquila, C.; Morvan, F.; Vasseur, J. J.; Imbach, J. L.; Rayner, B.
Nucleic Acids Res. 1998, 26 (9), 2069-2074. https://10.1093/nar/26.9.2069.
25. Anomeric inversion (from beta to alpha) in methylphosphonate oligonucleosides enhances their affinity for DNA and RNA.
Debart, F.; Meyer, A.; Vasseur, J. J.; Rayner, B.
Nucleic Acids Res. 1998, 26 (20), 4551-4556. https://10.1093/nar/26.20.4551.
24. A reinvestigation of sulfenyl groups as amino protecting groups for the synthesis of oligonucleotides on solid support by phosphoramidite chemistry.
Alvarez, K.; Tworkowski, I.; Vasseur, J. J.; Imbach, J. L.; Rayner, B.
Nucleosides Nucleotides Nucleic Acids 1998, 17 (1-3), 365-378. https://10.1080/07328319808005184.
23. Oligodeoxynucleoside phosphoramidates (P-NH2): Synthesis and thermal stability of duplexes with DNA and RNA targets.
Peyrottes, S.; Vasseur, J. J.; Imbach, J. L.; Rayner, B.
Nucleic Acids Res. 1996, 24 (10), 1841-1848. https://10.1093/nar/24.10.1841.
22. Dramatic effect of the anomeric configuration on the thermal stability of duplex formed between novel dodecathymidine phosphoramidate (P-NH2) and complementary DNA and RNA strands.
Peyrottes, S.; Vasseur, J. J.; Imbach, J. L.; Rayner, B.
Tetrahedron Lett. 1996, 37 (33), 5869-5872. https://10.1016/0040-4039(96)01250-6.
21. Oligonucleotide mimics for antisense therapeutics: Solution phase and automated solid-support synthesis of MMI linked oligomers.
Morvan, F.; Sanghvi, Y. S.; Perbost, M.; Vasseur, J. J.; Bellon, L.
J. Am. Chem. Soc. 1996, 118 (1), 255-256. https://10.1021/ja9533959.
20. An easy access of 2′,3′-dideoxy-3′-alpha-C-formyl-adenosine and 2′,3′-dideoxy-3′-alpha-C-formyl-guanosine analogs via stereoselective C-C bond-forming radical reaction.
Sanghvi, Y. S.; Ross, B.; Bharadwaj, R.; Vasseur, J. J.
Tetrahedron Lett. 1994, 35 (27), 4697-4700. https://10.1016/s0040-4039(00)76944-9.
19. Synthesis, base-pairing properties and nuclease resistance of oligothymidylate analogs containing methoxyphosphoramidate internucleoside linkages.
Peyrottes, S.; Vasseur, J. J.; Imbach, J. L.; Rayner, B.
Nucleosides Nucleotides 1994, 13 (10), 2135-2149. https://10.1080/15257779408013213.
18. Oligonucleosides – synthesis of a novel methylhydroxylamine-linked nucleoside dimer and its incorporation into antisense sequences.
Vasseur, J. J.; Debart, F.; Sanghvi, Y. S.; Cook, P. D.
J. Am. Chem. Soc. 1992, 114 (10), 4006-4007. https://10.1021/ja00036a076.
17. 9-Aminoellipticine-derivatized alpha- and beta-oligodeoxyribonucleotides targeted to the cap of beta-globin mRNA: hybridization to natural and engineered mRNA, inhibition of translation, and improved effect of tandem chains
Porumb, H.; Bertrand, J.-R.; Paoletti, J.; Vasseur, J. J.; Rayner, B.; Imbach, J.-L.; Malvy, C.
Antisense Res. Dev. 1992, 2 (4), 279-292. https://doi.org/10.1089/ard.1992.2.279.
16. Intermolecular radical C-C bond formation – synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides.
Debart, F.; Vasseur, J. J.; Sanghvi, Y. S.; Cook, P. D.
Tetrahedron Lett. 1992, 33 (19), 2645-2648. https://10.1016/s0040-4039(00)79047-2.
15. Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides.
Debart, F.; Vasseur, J. J.; Sanghvi, Y. S.; Cook, P. D.
Bioorg. Med. Chem. Lett. 1992, 2 (12), 1479-1482. https://10.1016/s0960-894x(00)80412-6.
14. Derivatization of oligonucleotides through abasic site formation.
Vasseur, J. J.; Peoch, D.; Rayner, B.; Imbach, J. L.
Nucleosides Nucleotides 1991, 10 (1-3), 107-117. https://10.1080/07328319108046439.
13. Polarity of annealing and structural-analysis of the RNase H resistant alpha-5′-d TACACA .Beta-5′-r AUGUGU hybrid determined by high-field H-1, C-13, and P-31 NMR analysis.
Gmeiner, W. H.; Rao, K. E.; Rayner, B.; Vasseur, J. J.; Morvan, F.; Imbach, J. L.; Lown, J. W.
Biochemistry 1990, 29 (45), 10329-10341. https://10.1021/bi00497a007.
12. Mutagenic properties of a unique abasic site in mammalian-cells.
Gentil, A.; Renault, G.; Madzak, C.; Margot, A.; Cabralneto, J. B.; Vasseur, J. J.; Rayner, B.; Imbach, J. L.; Sarasin, A.
Biochem. Biophys. Res. Commun. 1990, 173 (2), 704-710. https://10.1016/s0006-291x(05)80092-0.
11. Synthesis, thermal-stability and reactivity towards 9-aminoellipticine of double-stranded oligonucleotides containing a true abasic site.
Bertrand, J. R.; Vasseur, J. J.; Rayner, B.; Imbach, J. L.; Paoletti, J.; Paoletti, C.; Malvy, C.
Nucleic Acids Res. 1989, 17 (24), 10307-10319. https://10.1093/nar/17.24.10307.
10. Mechanism of cleavage of apurinic sites by 9-aminoellipticine.
Bertrand, J. R.; Vasseur, J. J.; Gouyette, A.; Rayner, B.; Imbach, J. L.; Paoletti, C.; Malvy, C.
J. Biol. Chem. 1989, 264 (24), 14172-14178. https://doi.org/10.1016/S0021-9258(18)71658-X.
9. Apurinic DNA reactivity – modelization of apurinic DNA breakage with phenylhydrazine and formation of a pyrazole adduct.
Vasseur, J. J.; Rayner, B.; Imbach, J. L.
J. Heterocycl. Chem. 1988, 25 (2), 389-392. https://10.1002/jhet.5570250207.
8. Efficient and easy synthesis of octathymidylate covalently linked to intercalating 9-aminoellipticine.
Vasseur, J. J.; Gauthier, C.; Rayner, B.; Paoletti, J.; Imbach, J. L.
Biochem. Biophys. Res. Commun. 1988, 152 (1), 56-61. https://10.1016/s0006-291x(88)80679-x.
7. Structure of the adduct formed between 3-aminocarbazole and the apurinic site oligonucleotide model d Tp(ap)pT.
Vasseur, J. J.; Rayner, B.; Imbach, J. L.; Verma, S.; McCloskey, J. A.; Lee, M.; Chang, D. K.; Lown, J. W.
J. Org. Chem. 1987, 52 (22), 4994-4998. https://10.1021/jo00231a028.
6. Preparation of a short synthetic apurinic oligonucleotide.
Vasseur, J. J.; Rayner, B.; Imbach, J. L.
Biochem. Biophys. Res. Commun. 1986, 134 (3), 1204-1208. https://10.1016/0006-291x(86)90378-5.
5. H-1-NMR assignments of the non-exchangeable protons of the consensus donor exon-intron junction d(CpApGpGpTpApApGpT).
Lown, J. W.; Hanstock, C. C.; Imbach, J. L.; Rayner, B.; Vasseur, J. J.
J. Biomol. Struct. Dyn. 1985, 2 (6), 1125-1135. https://10.1080/07391102.1985.10507628.
4. Synthesis, complete H-1 assignments and conformations of the self-complementary hexadeoxyribonucleotide d(CpGpApTpCpG)2 and its fragments by high-field NMR.
Lown, J. W.; Hanstock, C. C.; Bleackley, R. C.; Imbach, J. L.; Rayner, B.; Vasseur, J. J.
Nucleic Acids Res. 1984, 12 (5), 2519-2533. https://10.1093/nar/12.5.2519.
3. New lipophilic phosphate protecting group for the synthesis of oligonucleotides.
Vasseur, J. J.; Rayner, B.; Imbach, J. L.
Tetrahedron Lett. 1983, 24 (27), 2753-2756. https://10.1016/s0040-4039(00)88013-2.
2. Use of inter-proton nuclear overhauser effects to assign the nuclear magnetic-resonance spectra of oligodeoxynucleotide and hybrid duplexes in aqueous-solution.
Reid, D. G.; Salisbury, S. A.; Brown, T.; Williams, D. H.; Vasseur, J. J.; Rayner, B.; Imbach, J. L.
Eur. J. Biochem. 1983, 135 (2), 307-314. https://10.1111/j.1432-1033.1983.tb07654.x.
1. Synthesis of RNA oligonucleotides for use in the study of protein-synthesis.
Vasseur, J. J.; Rayner, B.; Pompon, A.; Imbach, J. L.
New J. Chem. 1981, 5 (5-6), 343-347. https://hal.archives-ouvertes.fr/hal-03726090.