Jean-Jacques Vasseur
232. Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases
M. Hausdorff, A. Delpal, S. Barelier, L. Nicollet, B. Canard, F. Touret, A. Colmant, B. Coutard, J.-J. Vasseur, E. Decroly, F. Debart
Eur. J. Med. Chem., 2023, 256, 115474.
231. AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5
Feracci, M., Eydoux, C., Fattorini, V., Lo Bello, L., Gauffre, P., Selisko, B., Sutto-Ortiz, P., Shannon, A., Xia, H., Shi, P.-Y., Noel, M., Debart, F., Vasseur, J.-J., Good, S., Lin, K., Moussa, A., Sommadossi, J.-P., Chazot, A., Alvarez, K., Guillemot, J.-C., Decroly, E., Ferron, F., Canard, B.
Antiviral Res., 2023, 105574.
230. Internal RNA 2’O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect
El Kazzi, P., Rabah, N., Chamontin, C., Poulain, L., Ferron, F., Debart, F., Canard, B., Missé, D., Coutard, B., Nisole, S. et al.
Nucleic Acids Res., 2023, 51, 2501-2515.
229. Importance of RNA length for in vitro encapsidation by the nucleoprotein of human Respiratory Syncytial Virus
Gonnin, L., Richard, C.-A., Gutsche, I., Chevret, D., Troussier, J., Vasseur, J.-J., Debart, F., Eléouët, J.-F., Galloux, M.
J. Biol. Chem., 2022, 298, 102337.
228. A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome
A. Shannon, B. Sama, P. Gauffre, T. Guez, F. Debart, J.-J. Vasseur, E. Decroly, B. Canard, F. Ferron
Nucleic Acid Research, 2022, 50, 11186–11198
227. Facile access to 4′-(N-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N7-guanine-methyltransferase nsp14
R. Amador, A. Delpal, B. Canard, J.-J. Vasseur, E. Decroly, F. Debart, G. Clavé,* M. Smietana*
Organic Biomolecular Chemistry, 2022, 20, 7582-7586.
226. A modular spring-loaded actuator for mechanical activation of membrane proteins.
Mills, A.; Aissaoui, N.; Maurel, D.; Elezgaray, J.; Morvan, F.; Vasseur, J. J.; Margeat, E.; Quast, R. B.; Kee-Him, J. L.; Saint, N.; Benistant, C.; Nord, A.; Pedaci, F.; Bellot, G.
Nat. Commun. 2022, 13 (1), 10. https://10.1038/s41467-022-30745-2.
225. Oligonucleotide Conjugation by Tyrosine-Click Reaction.
Meyer, A.; Baraguey, C.; Vasseur, J. J.; Morvan, F.
Eur. J. Org. Chem. 2022, 2022 (21), 10. https://10.1002/ejoc.202101361.
224. Direct Access to Unique C-5′-Acyl Modified Nucleosides through Liebeskind-Srogl Cross-Coupling Reaction.
Maverick, M. A.; Gaillard, M.; Vasseur, J. J.; Debart, F.; Smietana, M.
Eur. J. Org. Chem. 2022, 2022 (21), 5. https://10.1002/ejoc.202101061.
223. Applications of the Reversible Boronic Acids/Boronate Switch to Nucleic Acids.
Debiais, M.; Vasseur, J. J.; Smietana, M.
Chem. Rec. 2022, 17. https://10.1002/tcr.202200085.
222. Design and NMR characterization of reversible head-to-tail boronate-linked macrocyclic nucleic acids.
Debiais, M.; Molina, A. G.; Muller, S.; Vasseur, J. J.; Barvik, I.; Baraguey, C.; Smietana, M.
Org. Biomol. Chem. 2022, 20 (14), 2889-2895. https://10.1039/d2ob00232a.
221. Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues.
Ahmed-Belkacem, R.; Hausdorff, M.; Delpal, A.; Sutto-Ortiz, P.; Colmant, A. M. G.; Touret, F.; Ogando, N. S.; Snijder, E. J.; Canard, B.; Coutard, B.; Vasseur, J. J.; Decroly, E.; Debart, F.
J. Med. Chem. 2022, 65 (8), 6231-6249. https://10.1021/acs.jmedchem.2c00120.
220. Bisubstrate Strategies to Target Methyltransferases.
Ahmed-Belkacem, R.; Debart, F.; Vasseur, J. J.
Eur. J. Org. Chem. 2022, 2022 (21), 12. https://10.1002/ejoc.202101481.
219. First insights into the structural features of Ebola virus methyltransferase activities.
Valle, C.; Martin, B.; Ferron, F.; Roig-Zamboni, V.; Desmyter, A.; Debart, F.; Vasseur, J. J.; Canard, B.; Coutard, B.; Decroly, E.
Nucleic Acids Res. 2021, 49 (3), 1737-1748. https://10.1093/nar/gkaa1276.
218. The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2′-O-methylation.
Sutto-Ortiz, P.; Tcherniuk, S.; Ysebaert, N.; Abeywickrema, P.; Noel, M.; Decombe, A.; Debart, F.; Vasseur, J. J.; Canard, B.; Roymans, D.; Rigaux, P.; Eleouet, J. F.; Decroly, E.
PLoS Pathog. 2021, 17 (5), 20. https://10.1371/journal.ppat.1009562.
217. FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell.
Relier, S.; Ripoll, J.; Guillorit, H.; Amalric, A.; Achour, C.; Boissiere, F.; Vialaret, J.; Attina, A.; Debart, F.; Choquet, A.; Macari, F.; Marchand, V.; Motorin, Y.; Samalin, E.; Vasseur, J. J.; Pannequin, J.; Aguilo, F.; Lopez-Crapez, E.; Hirtz, C.; Rivals, E.; Bastide, A.; David, A.
Nat. Commun. 2021, 12 (1), 13. https://10.1038/s41467-021-21758-4.
216. Folding of phosphodiester-linked donor-acceptor oligomers into supramolecular nanotubes in water.
Perez de Carvasal, K.; Aissaoui, N.; Vergoten, G.; Bellot, G.; Vasseur, J. J.; Smietana, M.; Morvan, F.
Chem. Commun. 2021, 57 (34), 4130-4133. https://10.1039/d1cc01064f.
215. Diagnostic Performance of a Magnetic Field-Enhanced Agglutination Readout in Detecting Either Viral Genomes or Host Antibodies in Arbovirus Infection.
Leon, F.; Pinchon, E.; Temurok, N.; Morvan, F.; Vasseur, J. J.; Clot, M.; Foulongne, V.; Cantaloube, J. F.; Vande Perre, P.; Moles, J. P.; Daynes, A.; Fournier-Wirth, C.
Microorganisms 2021, 9 (4), 12. https://10.3390/microorganisms9040674.
214. Boronic Acid-Mediated Activity Control of Split 10-23 DNAzymes.
Debiais, M.; Lelievre, A.; Vasseur, J. J.; Muller, S.; Smietana, M.
Chem. Eur. J. 2021, 27 (3), 1138-1144. https://10.1002/chem.202004227.
213. Charge-Transfer Interactions Stabilize G-Quadruplex-Forming Thrombin Binding Aptamers and Can Improve Their Anticoagulant Activity.
de Carvasal, K. P.; Riccardi, C.; Krauss, I. R.; Cavasso, D.; Vasseur, J. J.; Smietana, M.; Morvan, F.; Montesarchio, D.
Int. J. Mol. Sci. 2021, 22 (17), 23. https://10.3390/ijms22179510.
212. Modified internucleoside linkages for nuclease-resistant oligonucleotides.
Clave, G.; Reverte, M.; Vasseur, J. J.; Smietana, M.
RSC Chem. Biol. 2021, 2 (1), 94-150. https://10.1039/d0cb00136h.
211. Efficient one-pot, three-component procedure to prepare new alpha-aminophosphonate and phosphonic acid acyclic nucleosides.
Baddi, L.; Ouzebla, D.; El Mansouri, A. E.; Smietana, M.; Vasseur, J. J.; Lazrek, H. B.
Nucleosides Nucleotides Nucleic Acids 2021, 40 (1), 43-67. https://10.1080/15257770.2020.1826516.
210. The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation.
Valle, C.; Martin, B.; Debart, F.; Vasseur, J. J.; Imbert, I.; Canard, B.; Coutard, B.; Decroly, E.
J. Virol. 2020, 94 (12), 14. https://10.1128/jvi.00520-20.
209. Fine-tuning the properties of the thrombin binding aptamer through cyclization: Effect of the 5 ‘-3 ‘ connecting linker on the aptamer stability and anticoagulant activity.
Riccardi, C.; Meyer, A.; Vasseur, J. J.; Krauss, I. R.; Paduano, L.; Morvan, F.; Montesarchio, D.
Bioorganic Chem. 2020, 94, 14. https://10.1016/j.bioorg.2019.103379.
208. Design, Synthesis and Characterization of Cyclic NU172 Analogues: A Biophysical and Biological Insight.
Riccardi, C.; Meyer, A.; Vasseur, J. J.; Cavasso, D.; Krauss, I. R.; Paduano, L.; Morvan, F.; Montesarchio, D.
Int. J. Mol. Sci. 2020, 21 (11), 26. https://10.3390/ijms21113860.
207. Rapid and specific DNA detection by magnetic field-enhanced agglutination assay.
Pinchon, E.; Leon, F.; Temurok, N.; Morvan, F.; Vasseur, J. J.; Clot, M.; Foulongne, V.; Cantaloube, J. F.; Vande Perre, P.; Daynes, A.; Moles, J. P.; Fournier-Wirth, C.
Talanta 2020, 219, 6. https://10.1016/j.talanta.2020.121344.
206. La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region (vol 46, pg 1457, 2018).
Philippe, L.; Vasseur, J. J.; Debart, F.; Thoreen, C. C.
Nucleic Acids Res. 2020, 48 (13), 7604-7605. https://10.1093/nar/gkaa535.
205. Machine Learning to Improve the Sensing of Biomolecules by Conical Track-Etched Nanopore.
Meyer, N.; Janot, J. M.; Lepoitevin, M.; Smietana, M.; Vasseur, J. J.; Torrent, J.; Balme, S.
Biosensors-Basel 2020, 10 (10), 13. https://10.3390/bios10100140.
204. DNA-Based Asymmetric Inverse Electron-Demand Hetero-Diels-Alder.
Mansot, J.; Lauberteaux, J.; Lebrun, A.; Mauduit, M.; Vasseur, J. J.; de Figueiredo, R. M.; Arseniyadis, S.; Campagne, J. M.; Smietana, M.
Chem. Eur. J. 2020, 26 (16), 3519-3523. https://10.1002/chem.202000516.
203. Modified Galacto- or Fuco-Clusters Exploiting the Siderophore Pathway to Inhibit the LecA- or LecB-Associated Virulence ofPseudomonas aeruginosa.
Madaoui, M.; Vidal, O.; Meyer, A.; Noel, M.; Lacroix, J. M.; Vasseur, J. J.; Marra, A.; Morvan, F.
ChemBioChem 2020, 21 (23), 3433-3448. https://10.1002/cbic.202000490.
202. Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers.
Gauthier, F.; Bertrand, J. R.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Molecules 2020, 25 (11), 15. https://10.3390/molecules25112714.
201. Selective Chemical Modification of DNA with Boronic Acids by On-Column CuAAc Reactions.
Debiais, M.; Vasseur, J. J.; Muller, S.; Smietana, M.
Synthesis 2020, 52 (20), 2962-2969. https://10.1055/s-0040-1707194.
200. An Entry of the Chemoselective Sulfo-Click Reaction into the Sphere of Nucleic Acids.
Clave, G.; Dursun, E.; Vasseur, J. J.; Smietana, M.
Org. Lett. 2020, 22 (5), 1914-1918. https://10.1021/acs.orglett.0c00265.
199. Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase.
Ahmed-Belkacem, R.; Sutto-Ortiz, P.; Guiraud, M.; Canard, B.; Vasseur, J. J.; Decroly, E.; Debart, F.
Eur. J. Med. Chem. 2020, 201, 16. https://10.1016/j.ejmech.2020.112557.
198. Deciphering multivalent glycocluster-lectin interactions through AFM characterization of the self-assembled nanostructures.
Zuttion, F.; Sicard, D.; Dupin, L.; Vergoten, G.; Girard-Bock, C.; Madaoui, M.; Chevolot, Y.; Morvan, F.; Vidal, S.; Vasseur, J. J.; Souteyrand, E.; Phaner-Goutorbe, M.
Soft Matter 2019, 15 (36), 7211-7218. https://10.1039/c9sm00371a.
197. Stability Is Not Everything: The Case of the Cyclisation of a Thrombin-Binding Aptamer.
Riccardi, C.; Meyer, A.; Vasseur, J. J.; Krauss, I. R.; Paduano, L.; Oliva, R.; Petraccone, L.; Morvan, F.; Montesarchio, D.
ChemBioChem 2019, 20 (14), 1789-1794. https://10.1002/cbic.201900045.
196. Difluorophosphonylated Allylic Ether Moiety as a 2 ‘-Modification of RNA-Type Molecules: Synthesis, Thermal, and Metabolic Studies.
Pfund, E.; Dupouy, C.; Rouanet, S.; Legay, R.; Lebargy, C.; Vasseur, J. J.; Lequeux, T.
Org. Lett. 2019, 21 (12), 4803-4807. https://10.1021/acs.orglett.9b01689.
195. Solid Supports for the Synthesis of 3 ‘-Aminooxy Deoxy- or Ribo-oligonucleotides and Their
3′-Conjugation by Oxime Ligation.
Noeel, M.; Cleement-Blanc, C.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2019, 84 (22), 14854-14860. https://10.1021/acs.joc.9b00848.
194. Combining Chemical Synthesis and Enzymatic Methylation to Access Short RNAs with Various 5 ‘ Caps.
Muthmann, N.; Guez, T.; Vasseur, J. J.; Jaffrey, S. R.; Debart, F.; Rentmeister, A.
ChemBioChem 2019, 20 (13), 1693-1700. https://10.1002/cbic.201900037.
193. FTO controls reversible m(6)Am RNA methylation during snRNA biogenesis.
Mauer, J.; Sindelar, M.; Despic, V.; Guez, T.; Hawley, B. R.; Vasseur, J. J.; Rentmeister, A.; Gross, S. S.; Pellizzoni, L.; Debart, F.; Goodarzis, H.; Jaffrey, S. R.
Nat. Chem. Biol. 2019, 15 (4), 340-+. https://10.1038/s41589-019-0231-8.
192. alpha,beta-Unsaturated 2-Acyl-Imidazoles in Asymmetric Biohybrid Catalysis.
Mansot, J.; Vasseur, J. J.; Arseniyadis, S.; Smietana, M.
ChemCatChem 2019, 11 (23), 5686-5704. https://10.1002/cctc.201900743.
191. A rational quest for selectivity through precise ligand-positioning in tandem DNA-catalysed Friedel-Crafts alkylation/asymmetric protonation.
Mansot, J.; Aubert, S.; Duchemin, N.; Vasseur, J. J.; Arseniyadis, S.; Smietana, M.
Chem. Sci. 2019, 10 (10), 2875-2881. https://10.1039/c8sc05543b.
190. Thermolytic Reagents to Synthesize 5-or 3-Mono(thio)phosphate Oligodeoxynucleotides or 3-modified oligodeoxynucleotides.
Madaoui, M.; Meyer, A.; Vasseur, J. J.; Morvan, F.
Eur. J. Org. Chem. 2019, 2019 (17), 2832-2842. https://10.1002/ejoc.201900302.
189. An Innovative Multiplexed and Flexible Molecular Approach for the Differential Detection of Arboviruses.
Leon, F.; Meyer, A.; Reynier, R.; Blanc, E.; Bruyere-Ostells, L.; Bres, J. C.; Simonin, Y.; Salinas, S.; Gallian, P.; Leparc-Goffart, I.; Biron, A.; Dupont-Rouzeyrol, M.; Morvan, F.; Vasseur, J. J.; Foulongne, V.; Van de Perre, P.; Cantaloube, J. F.; Fournier-Wirth, C.
J. Mol. Diagn. 2019, 21 (1), 81-88. https://10.1016/j.jmoldx.2018.08.005.
188. Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.
Larcher, A.; Nocentin, A.; Supuran, C. T.; Winum, J. Y.; van der Lee, A.; Vasseur, J. J.; Laurencin, D.; Smietana, M.
ACS Med. Chem. Lett. 2019, 10 (8), 1205-1210. https://10.1021/acsmedchemlett.9b00252.
187. Conjugation of Small Molecules to RNA Using a Reducible Disulfide Linker Attached at the 2 ‘-OH Position through a Carbamate Function.
Gauthier, F.; Malher, A.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Eur. J. Org. Chem. 2019, 2019 (33), 5636-5645. https://10.1002/ejoc.201900740.
186. Identification of the m(6)Am Methyltransferase PCIF1 Reveals the Location and Functions of m(6)Am in the Transcriptome.
Boulias, K.; Toczydlowska-Socha, D.; Hawley, B.; Liberman, N.; Takashima, K.; Zaccara, S.; Guez, T.; Vasseur, J. J.; Debart, F.; Aravind, L.; Jaffrey, S. R.; Greer, E. L.
Mol. Cell 2019, 75 (3), 631-+. https://10.1016/j.molcel.2019.06.006.
185. Synthesis of Adenine Dinucleosides 2 ‘,5 ‘-Bridged by Sulfur-Containing Linkers as Bisubstrate SAM Analogues for Viral RNA 2 ‘-O-Methyltransferases.
Ahmed-Belkacem, R.; Ortiz, P. S.; Decroly, E.; Vasseur, J. J.; Debart, F.
Eur. J. Org. Chem. 2019, 2019 (38), 6486-6495. https://10.1002/ejoc.201901120.
184. The anti-adhesive effect of glycoclusters on Pseudomonas aeruginosa bacteria adhesion to epithelial cells studied by AFM single cell force spectroscopy.
Zuttion, F.; Ligeour, C.; Vidal, O.; Walte, M.; Morvan, F.; Vidal, S.; Vasseur, J. J.; Chevolot, Y.; Phaner-Goutorbe, M.; Schillers, H.
Nanoscale 2018, 10 (26), 12771-12778. https://10.1039/c8nr03285h.
183. La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region.
Philippe, L.; Vasseur, J. J.; Debart, F.; Thoreen, C. C.
Nucleic Acids Res. 2018, 46 (3), 1457-1469. https://10.1093/nar/gkx1237.
182. RNA- based boronate internucleosidic linkages: an entry into reversible templated ligation and loop formation.
Molina, A. G.; Barvik, I.; Muller, S.; Vasseur, J. J.; Smietana, M.
Org. Biomol. Chem. 2018, 16 (45), 8824-8830. https://10.1039/c8ob02182a.
181. The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure.
Martin, B.; Coutard, B.; Guez, T.; Paesen, G. C.; Canard, B.; Debart, F.; Vasseur, J. J.; Grimes, J. M.; Decroly, E.
Nucleic Acids Res. 2018, 46 (15), 7902-7912. https://10.1093/nar/gky637.
180. Gymnotic delivery and gene silencing activity of reduction-responsive siRNAs bearing lipophilic disulfide-containing modifications at 2 ‘-position.
Gauthier, F.; Claveau, S.; Bertrand, J. R.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Bioorg. Med. Chem. 2018, 26 (16), 4635-4643. https://10.1016/j.bmc.2018.07.033.
179. A 2 ‘,2 ‘-disulfide-bridged dinucleotide conformationally locks RNA hairpins.
Gauthier, F.; Beltran, F.; Biscans, A.; Debart, F.; Dupouy, C.; Vasseur, J. J.
Org. Biomol. Chem. 2018, 16 (17), 3181-3188. https://10.1039/c8ob00328a.
178. Screening of a Library of Oligosaccharides Targeting Lectin LecB of Pseudomonas Aeruginosa and Synthesis of High Affinity Oligoglycoclusters.
Dupin, L.; Noel, M.; Bonnet, S.; Meyer, A.; Gehin, T.; Bastide, L.; Randriantsoa, M.; Souteyrand, E.; Cottin, C.; Vergoten, G.; Vasseur, J. J.; Morvan, F.; Chevolot, Y.; Darblade, B.
Molecules 2018, 23 (12), 24. https://10.3390/molecules23123073.
177. DNA-Templated 2+2 Photocycloaddition: A Straightforward Entry into the Aplysinopsin Family of Natural Products.
Duchemin, N.; Skiredj, A.; Mansot, J.; Leblanc, K.; Vasseur, J. J.; Beniddir, M. A.; Evanno, L.; Poupon, E.; Smietana, M.; Arseniyadis, S.
Angew. Chem. Int. Ed. 2018, 57 (36), 11786-11791. https://10.1002/anie.201806357.
176. Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing.
Debart, F.; Dupouy, C.; Vasseur, J. J.
Beilstein J. Org. Chem. 2018, 14, 436-469. https://10.3762/bjoc.14.32.
175. Template-directed excimer formation via specific non-covalent interactions between pyrene guanidinium derivatives and nucleic acids.
Amirbekyan, K.; Mansot, J.; Ohara, K.; Markarian, S. A.; Vasseur, J. J.; Smietana, M.
Tetrahedron Lett. 2018, 59 (3), 295-298. https://10.1016/j.tetlet.2017.12.046.
174. Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress.
Tamarkin-Ben-Harush, A.; Vasseur, J. J.; Debart, F.; Ulitsky, I.; Dikstein, R.
eLife 2017, 6, 21. https://10.7554/eLife.21907.
173. Fluorescent Thrombin Binding Aptamer-Tagged Nanoparticles for an Efficient and Reversible Control of Thrombin Activity.
Riccardi, C.; Krauss, I. R.; Musumeci, D.; Morvan, F.; Meyer, A.; Vasseur, J. J.; Paduano, L.; Montesarchio, D.
ACS Appl. Mater. Interfaces 2017, 9 (41), 35574-35587. https://10.1021/acsami.7b11195.
172. RNA-directed off/on switch of RNase H activity using boronic ester formation.
Reverte, M.; Barvik, I.; Vasseur, J. J.; Smietana, M.
Org. Biomol. Chem. 2017, 15 (38), 8204-8210. https://10.1039/c7ob02145c.
171. Contribution to PNA-RNA Chimera Synthesis: One-Pot Microwave-Assisted Ugi Reaction to Obtain Dimeric Building Blocks.
Ovadia, R.; Mondielli, C.; Vasseur, J. J.; Baraguey, C.; Alvarez, K.
Eur. J. Org. Chem. 2017, 2017 (3), 469-475. https://10.1002/ejoc.201601190.
170. Phthalimide-Oxy Derivatives for 3-or 5-Conjugation of Oligonucleotides by Oxime Ligation and Circularization of DNA by “Bis- or Tris-Click” Oxime Ligation.
Meyer, A.; Vasseur, J. J.; Dumy, P.; Morvan, F.
Eur. J. Org. Chem. 2017, 2017 (46), 6931-6941. https://10.1002/ejoc.201701317.
169. Reversible methylation of m(6)A(m) in the 5 ‘ cap controls mRNA stability.
Mauer, J.; Luo, X. B.; Blanjoie, A.; Jiao, X. F.; Grozhik, A. V.; Patil, D. P.; Linder, B.; Pickering, B. F.; Vasseur, J. J.; Chen, Q. Y.; Gross, S. S.; Elemento, O.; Debart, F.; Kiledjian, M.; Jaffrey, S. R.
Nature 2017, 541 (7637), 371-+. https://10.1038/nature21022.
168. Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
Coutard, B.; Barral, K.; Lichiere, J.; Selisko, B.; Martin, B.; Aouadi, W.; Lombardia, M. O.; Debart, F.; Vasseur, J. J.; Guillemot, J. C.; Canard, B.; Decroly, E.
J. Virol. 2017, 91 (5), 15. https://10.1128/jvi.02202-16.
167. Synthesis of 3 ‘-deoxy-3 ‘-iminodiacetic acid and 3 ‘-deoxy-3 ‘-aminodiethanol thymidine analogues and NMR study of their complexation with boronic acids.
Barbeyron, R.; Vasseur, J. J.; Baraguey, C.; Smietana, M.
Tetrahedron 2017, 73 (17), 2468-2475. https://10.1016/j.tet.2017.03.033.
166. Improved Performance of DNA Microarray Multiplex Hybridization Using Probes Anchored at Several Points by Thiol-Ene or Thiol-Yne Coupling Chemistry.
Banuls, M. J.; Jimenez-Meneses, P.; Meyer, A.; Vasseur, J. J.; Morvan, F.; Escorihuela, J.; Puchades, R.; Maquieira, A.
Bioconjugate Chem. 2017, 28 (2), 496-506. https://10.1021/acs.bioconjchem.6b00624.
165. Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay.
Aouadi, W.; Eydoux, C.; Coutard, B.; Martin, B.; Debart, F.; Vasseur, J. J.; Contreras, J. M.; Morice, C.; Querat, G.; Jung, M. L.; Canard, B.; Guillemot, J. C.; Decroly, E.
Antiviral Res. 2017, 144, 330-339. https://10.1016/j.antiviral.2017.06.021.
164. Binding of the Methyl Donor S-Adenosyl-L-Methionine to Middle East Respiratory Syndrome Coronavirus 2 ‘-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.
Aouadi, W.; Blanjoie, A.; Vasseur, J. J.; Debart, F.; Canard, B.; Decroly, E.
J. Virol. 2017, 91 (5), 18. https://10.1128/jvi.02217-16.
163. Design and Synthesis of Galactosylated Bifurcated Ligands with Nanomolar Affinity for Lectin LecA from Pseudomonas aeruginosa.
Angeli, A.; Li, M. C.; Dupin, L.; Vergoten, G.; Noel, M.; Madaoui, M.; Wang, S.; Meyer, A.; Gehin, T.; Vidal, S.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
ChemBioChem 2017, 18 (11), 1036-1047. https://10.1002/cbic.201700154.
162. Glycoclusters with Additional Functionalities for Binding to the LecA Lectin from Pseudomonas aeruginosa.
Angeli, A.; Dupin, L.; Madaoui, M.; Li, M. C.; Vergoten, G.; Wang, S.; Meyer, A.; Gehin, T.; Vidal, S.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
ChemistrySelect 2017, 2 (32), 10420-10427. https://10.1002/slct.201702131.
161. Toward the Rational Design of Galactosylated Glycoclusters That Target Pseudomonas aeruginosa Lectin A (LecA): Influence of Linker Arms That Lead to Low-Nanomolar Multivalent Ligands.
Wang, S.; Dupin, L.; Noel, M.; Carroux, C. J.; Renaud, L.; Gehin, T.; Meyer, A.; Souteyrand, E.; Vasseur, J. J.; Vergoten, G.; Chevolot, Y.; Morvan, F.; Vidal, S.
Chem. Eur. J. 2016, 22 (33), 11785-11794. https://10.1002/chem.201602047.
160. Detection of short ssDNA and dsDNA by current-voltage measurements using conical nanopores coated with Al2O3 by atomic layer deposition.
Thangaraj, V.; Lepoitevin, M.; Smietana, M.; Balanzat, E.; Bechelany, M.; Janot, J. M.; Vasseur, J. J.; Subramanian, S.; Balme, S.
Microchim. Acta 2016, 183 (3), 1011-1017. https://10.1007/s00604-015-1706-2.
159. RNase H-Assisted Imaging of Peroxynitrite in Living Cells with 5 ‘-Boronic Acid Modified DNA.
Reverte, M.; Vaissiere, A.; Boisguerin, P.; Vasseur, J. J.; Smietana, M.
ACS Sens. 2016, 1 (8), 970-974. https://10.1021/acssensors.6b00401.
158. Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA.
Duchemin, N.; Benedetti, E.; Bethge, L.; Vonhoff, S.; Klussmann, S.; Vasseur, J. J.; Cossy, J.; Smietana, M.; Arseniyadis, S.
Chem. Commun. 2016, 52 (55), 8604-8607. https://10.1039/c6cc03540j.
157. A versatile post-synthetic method on a solid support for the synthesis of RNA containing reduction-responsive modifications.
Biscans, A.; Rouanet, S.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Org. Biomol. Chem. 2016, 14 (29), 7010-7017. https://10.1039/c6ob01272h.
156. Lipophilic 2-O-Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery.
Biscans, A.; Bertrand, J. R.; Dubois, J.; Ruger, J.; Vasseur, J. J.; Sczakiel, G.; Dupouy, C.; Debart, F.
ChemBioChem 2016, 17 (21), 2054-2062. https://10.1002/cbic.201600317.
155. Design, Synthesis, and Binding Affinity Evaluation of Hoechst 33258 Derivatives for the Development of Sequence-Specific DNA-Based Asymmetric Catalysts.
Amirbekyan, K.; Duchemin, N.; Benedetti, E.; Joseph, R.; Colon, A.; Markarian, S. A.; Bethge, L.; Vonhoff, S.; Klussmann, S.; Cossy, J.; Vasseur, J. J.; Arseniyadis, S.; Smietana, M.
ACS Catal. 2016, 6 (5), 3096-3105. https://10.1021/acscatal.6b00495.
154. Solid-Phase Synthesis of Oligonucleotide 5 ‘-(alpha-P-Thio)triphosphates and 5 ‘-(alpha-P-Thio)(beta,gamma-methylene)triphosphates.
Thillier, Y.; Sallamand, C.; Baraguey, C.; Vasseur, J. J.; Debart, F.
Eur. J. Org. Chem. 2015, 2015 (2), 302-308. https://10.1002/ejoc.201403381.
153. Nuclease stability of boron-modified nucleic acids: application to label-free mismatch detection.
Reverte, M.; Vasseur, J. J.; Smietana, M.
Org. Biomol. Chem. 2015, 13 (43), 10604-10608. https://10.1039/c5ob01815c.
152. X-ray structure and activities of an essential Mononegavirales L-protein domain.
Paesen, G. C.; Collet, A.; Sallamand, C.; Debart, F.; Vasseur, J. J.; Canard, B.; Decroly, E.; Grimes, J. M.
Nat. Commun. 2015, 6, 10. https://10.1038/ncomms9749.
151. Synthesis and structural characterization of monomeric and dimeric peptide nucleic acids prepared by using microwave-promoted multicomponent reactions.
Ovadia, R.; Lebrun, A.; Barvik, I.; Vasseur, J. J.; Baraguey, C.; Alvarez, K.
Org. Biomol. Chem. 2015, 13 (45), 11052-11071. https://10.1039/c5ob01604e.
150. Hetero-Click Conjugation of Oligonucleotides with Glycosides Using Bifunctional Phosphoramidites.
Meyer, A.; Noel, M.; Vasseur, J. J.; Morvan, F.
Eur. J. Org. Chem. 2015, 2015 (13), 2921-2927. https://10.1002/ejoc.201500165.
149. Mannose-centered aromatic galactoclusters inhibit the biofilm formation of Pseudomonas aeruginosa.
Ligeour, C.; Vidal, O.; Dupin, L.; Casoni, F.; Gillon, E.; Meyer, A.; Vidal, S.; Vergoten, G.; Lacroix, J. M.; Souteyrand, E.; Imberty, A.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Org. Biomol. Chem. 2015, 13 (31), 8433-8444. https://10.1039/c5ob00948k.
148. Importance of topology for glycocluster binding to Pseudomonas aeruginosa and Burkholderia ambifaria bacterial lectins.
Ligeour, C.; Dupin, L.; Angeli, A.; Vergoten, G.; Vidal, S.; Meyer, A.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Org. Biomol. Chem. 2015, 13 (46), 11244-11254. https://10.1039/c5ob01445j.
147. mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research.
Li, C. Q.; Guillen, J.; Rabah, N.; Blanjoie, A.; Debart, F.; Vasseur, J. J.; Canard, B.; Decroly, E.; Coutard, B.
J. Virol. 2015, 89 (16), 8292-8303. https://10.1128/jvi.00599-15.
146. Assessment of the Full Compatibility of Copper(I)-Catalyzed Alkyne-Azide Cycloaddition and Oxime Click Reactions for bis-Labelling of Oligonucleotides.
Estalayo-Adrian, S.; Lartia, R.; Meyer, A.; Vasseur, J. J.; Morvan, F.; Defrancq, E.
ChemistryOpen 2015, 4 (2), 169-173. https://10.1002/open.201402099.
145. Effects of the Surface Densities of Glycoclusters on the Determination of Their IC50 and K-d Value Determination by Using a Microarray.
Dupin, L.; Zuttion, F.; Gehin, T.; Meyer, A.; Phaner-Goutorbe, M.; Vasseur, J. J.; Souteyrand, E.; Morvan, F.; Chevolot, Y.
ChemBioChem 2015, 16 (16), 2329-2336. https://10.1002/cbic.201500371.
144. Synthesis, binding, nuclease resistance and cellular uptake properties of 2 ‘-O-acetalester-modified oligonucleotides containing cationic groups.
Biscans, A.; Rouanet, S.; Bertrand, J. R.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Bioorg. Med. Chem. 2015, 23 (17), 5360-5368. https://10.1016/j.bmc.2015.07.054.
143. DNA-cellulose: an economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis.
Benedetti, E.; Duchemin, N.; Bethge, L.; Vonhoff, S.; Klussmann, S.; Vasseur, J. J.; Cossy, J.; Smietana, M.; Arseniyadis, S.
Chem. Commun. 2015, 51 (28), 6076-6079. https://10.1039/c4cc10190a.
142. Chemical Biology of Nucleic Acids.
Barciszewski, J.; Marquez, V. E.; Vasseur, J. J.; Markiewicz, W. T.
ACS Chem. Biol. 2015, 10 (6), 1358-1361. https://10.1021/acschembio.5b00320.
141. pH-controlled DNA- and RNA-templated assembly of short oligomers.
Barbeyron, R.; Vasseur, J. J.; Smietana, M.
Chem. Sci. 2015, 6 (1), 542-547. https://10.1039/c4sc03028a.
140. DNA-templated borononucleic acid self assembly: a study of minimal complexity.
Barbeyron, R.; Martin, A. R.; Vasseur, J. J.; Smietana, M.
RSC Adv. 2015, 5 (128), 105587-105591. https://10.1039/c5ra20767c.
139. Synthesis of Galactoclusters by Metal-Free Thiol “Click Chemistry” and Their Binding Affinities for Pseudomonas aeruginosa Lectin LecA.
Ligeour, C.; Dupin, L.; Marra, A.; Vergoten, G.; Meyer, A.; Dondoni, A.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Eur. J. Org. Chem. 2014, 2014 (34), 7621-7630. https://10.1002/ejoc.201402902.
138. Structure Binding Relationship of Galactosylated Glycoclusters toward Pseudomonas aeruginosa Lectin LecA Using a DNA-Based Carbohydrate Microarray.
Gerland, B.; Goudot, A.; Ligeour, C.; Pourceau, G.; Meyer, A.; Vidal, S.; Gehin, T.; Vidal, O.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Bioconjugate Chem. 2014, 25 (2), 379-392. https://10.1021/bc4005365.
137. Ecological catalysis and phytoextraction: Symbiosis for future.
Escande, V.; Garoux, L.; Grison, C.; Thillier, Y.; Debart, F.; Vasseur, J. J.; Boulanger, C.; Grison, C.
Appl. Cat. B 2014, 146, 279-288. https://10.1016/j.apcatb.2013.04.011.
136. Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents.
Elayadi, H.; Smietana, M.; Vasseur, J. J.; Balzarini, J.; Lazrek, H. B.
Arch. Pharm. 2014, 347 (2), 134-141. https://10.1002/ardp.201300260.
135. DNA directed immobilization glycocluster array: applications and perspectives.
Chevolot, Y.; Laurenceau, E.; Phaner-Goutorbe, M.; Monnier, V.; Souteyrand, E.; Meyer, A.; Gehin, T.; Vasseur, J. J.; Morvan, F.
Curr. Opin. Chem. Biol. 2014, 18, 46-54. https://10.1016/j.cbpa.2013.12.009.
134. The influence of the aromatic aglycon of galactoclusters on the binding of LecA: a case study with O-phenyl, S-phenyl, O-benzyl, S-benzyl, O-biphenyl and O-naphthyl aglycons.
Casoni, F.; Dupin, L.; Vergoten, G.; Meyer, A.; Ligeour, C.; Gehin, T.; Vidal, O.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Org. Biomol. Chem. 2014, 12 (45), 9166-9179. https://10.1039/c4ob01599a.
133. Synthesis of New Lipoic Acid Conjugates and Evaluation of Their Free Radical Scavenging and Neuroprotective Activities.
Bolognesi, M. L.; Bergamini, C.; Fato, R.; Oiry, J.; Vasseur, J. J.; Smietana, M.
Chem. Biol. Drug Des. 2014, 83 (6), 688-696. https://10.1111/cbdd.12282.
132. Direct Synthesis of Partially Modified 2 ‘-O-Pivaloyloxymethyl RNAs by a Base-Labile Protecting Group Strategy and their Potential for Prodrug-Based Gene-Silencing Applications.
Biscans, A.; Bos, M.; Martin, A. R.; Ader, N.; Sczakiel, G.; Vasseur, J. J.; Dupouy, C.; Debart, F.
ChemBioChem 2014, 15 (18), 2674-2679. https://10.1002/cbic.201402382.
131. Recent developments in alkyne borylations.
Barbeyron, R.; Benedetti, E.; Cossy, J.; Vasseur, J. J.; Arseniyadis, S.; Smietana, M.
Tetrahedron 2014, 70 (45), 8431-8452. https://10.1016/j.tet.2014.06.026.
130. DNA vs. Mirror-Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA-Based Asymmetric Catalysis.
Wang, J.; Benedetti, E.; Bethge, L.; Vonhoff, S.; Klussmann, S.; Vasseur, J. J.; Cossy, J.; Smietana, M.; Arseniyadis, S.
Angew. Chem. Int. Ed. 2013, 52 (44), 11546-11549. https://10.1002/anie.201306232.
129. Solid-phase synthesis of 5′-triphosphate 2′-5′-oligoadenylates analogs with 3′-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.
Thillier, Y.; Stevens, S. K.; Moy, C.; Taylor, J.; Vasseur, J. J.; Beigelman, L.; Debart, F.
Bioorg. Med. Chem. 2013, 21 (17), 5461-5469. https://10.1016/j.bmc.2013.06.008.
128. Metallophyte wastes and polymetallic catalysis: a promising combination in green chemistry. The illustrative synthesis of 5 ‘-capped RNA.
Thillier, Y.; Losfeld, G.; Escande, V.; Dupouy, C.; Vasseur, J. J.; Debart, F.; Grison, C.
RSC Adv. 2013, 3 (15), 5204-5212. https://10.1039/c3ra23115a.
127. Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates.
Piton, J.; Larue, V.; Thillier, Y.; Dorleans, A.; Pellegrini, O.; de la Sierra-Gallay, I. L.; Vasseur, J. J.; Debart, F.; Tisne, C.; Condon, C.
Proc. Natl. Acad. Sci. U. S. A. 2013, 110 (22), 8858-8863. https://10.1073/pnas.1221510110.
126. Synthesis of Monoconjugated and Multiply Conjugated Oligonucleotides by “Click Thiol” Thiol-Michael-Type Additions and by Combination with CuAAC “Click Huisgen”.
Meyer, A.; Vasseur, J. J.; Morvan, F.
Eur. J. Org. Chem. 2013, 2013 (3), 465-473. https://10.1002/ejoc.201201311.
125. Boron and nucleic acid chemistries: merging the best of both worlds.
Martin, A. R.; Vasseur, J. J.; Smietana, M.
Chem. Soc. Rev. 2013, 42 (13), 5684-5713. https://10.1039/c3cs60038f.
124. Synthesis of branched-phosphodiester and mannose-centered fucosylated glycoclusters and their binding studies with Burkholderia ambifaria lectin (BambL).
Ligeour, C.; Audfray, A.; Gillon, E.; Meyer, A.; Galanos, N.; Vidal, S.; Vasseur, J. J.; Imberty, A.; Morvan, F.
RSC Adv. 2013, 3 (42), 19515-19524. https://10.1039/c3ra43807d.
123. Development of Innovative and Versatile Polythiol Probes for Use on ELOSA or Electrochemical Biosensors: Application in Hepatitis C Virus Genotyping.
Lereau, M.; Fournier-Wirth, C.; Mayen, J.; Farre, C.; Meyer, A.; Dugas, V.; Cantaloube, J. F.; Chaix, C.; Vasseur, J. J.; Morvan, F.
Anal. Chem. 2013, 85 (19), 9204-9212. https://10.1021/ac401941x.
122. Quantitative analysis (K-d and IC50) of glycoconjugates interactions with a bacterial lectin on a carbohydrate microarray with DNA Direct Immobilization (DDI).
Goudot, A.; Pourceau, G.; Meyer, A.; Gehin, T.; Vidal, S.; Vasseur, J. J.; Morvan, F.; Souteyrand, E.; Chevolot, Y.
Biosens. Bioelectron. 2013, 40 (1), 153-160. https://10.1016/j.bios.2012.07.003.
121. Fluorescence Enhancement upon G-Quadruplex Folding: Synthesis, Structure, and Biophysical Characterization of a Dansyl/Cyclodextrin-Tagged Thrombin Binding Aptamer.
De Tito, S.; Morvan, F.; Meyer, A.; Vasseur, J. J.; Cummaro, A.; Petraccone, L.; Pagano, B.; Novellino, E.; Randazzo, A.; Giancola, C.; Montesarchio, D.
Bioconjugate Chem. 2013, 24 (11), 1917-1927. https://10.1021/bc400352s.
120. Development of specific dengue virus 2 ‘-O- and N7-methyltransferase assays for antiviral drug screening.
Barral, K.; Sallamand, C.; Petzold, C.; Coutard, B.; Collet, A.; Thillier, Y.; Zimmermann, J.; Vasseur, J. J.; Canard, B.; Rohayem, J.; Debart, F.; Decroly, E.
Antiviral Res. 2013, 99 (3), 292-300. https://10.1016/j.antiviral.2013.06.001.
119. Boronic acid-based autoligation of nucleic acids: influence of the nature of the 3 ‘-end ribonucleotidic strand.
Barbeyron, R.; Wengel, J.; Vasseur, J. J.; Smietana, M.
Mon. Chem. 2013, 144 (4), 495-500. https://10.1007/s00706-012-0881-7.
118. The biolabile 2 ‘-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure.
Baraguey, C.; Lescrinier, E.; Lavergne, T.; Debart, F.; Herdewijn, P.; Vasseur, J. J.
Org. Biomol. Chem. 2013, 11 (16), 2638-2647. https://10.1039/c3ob27005j.
117. Synthesis of 5 ‘ cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N-7)-methyl transferase.
Thillier, Y.; Decroly, E.; Morvan, F.; Canard, B.; Vasseur, J. J.; Debart, F.
RNA 2012, 18 (4), 856-868. https://10.1261/rna.030932.111.
116. Dynamic boronic acid-mediated autoligation of DNA strands.
Smietana, M.; Martin, A. R.; Vasseur, J. J.
Pure Appl. Chem. 2012, 84 (7), 1659-1667. https://10.1351/pac-con-11-09-28.
115. Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome.
Selisko, B.; Potisopon, S.; Agred, R.; Priet, S.; Varlet, I.; Thillier, Y.; Sallamand, C.; Debart, F.; Vasseur, J. J.; Canard, B.
PLoS Pathog. 2012, 8 (9), 13. https://10.1371/journal.ppat.1002912.
114. DNA glycoclusters and DNA-based carbohydrate microarrays: From design to applications.
Morvan, F.; Vidal, S.; Souteyrand, E.; Chevolot, Y.; Vasseur, J. J.
RSC Adv. 2012, 2 (32), 12043-12068. https://10.1039/c2ra21550k.
113. Bis- and Tris-Alkyne Phosphoramidites for Multiple 5′-Labeling of Oligonucleotides by Click Chemistry.
Ligeour, C.; Meyer, A.; Vasseur, J. J.; Morvan, F.
Eur. J. Org. Chem. 2012, 2012 (9), 1851-1856. https://10.1002/ejoc.201101763.
112. Synthesis of Homo- and Heterofunctionalized Glycoclusters and Binding to Pseudomonas aeruginosa Lectins PA-IL and PA-IIL.
Gerland, B.; Goudot, A.; Pourceau, G.; Meyer, A.; Vidal, S.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
J. Org. Chem. 2012, 77 (17), 7620-7626. https://10.1021/jo300826u.
111. Synthesis of a Library of Fucosylated Glycoclusters and Determination of their Binding toward Pseudomonas aeruginosa Lectin B (PA-IIL) Using a DNA-Based Carbohydrate Microarray.
Gerland, B.; Goudot, A.; Pourceau, G.; Meyer, A.; Dugas, V.; Cecioni, S.; Vidal, S.; Souteyrand, E.; Vasseur, J. J.; Chevolot, Y.; Morvan, F.
Bioconjugate Chem. 2012, 23 (8), 1534-1547. https://10.1021/bc2006434.
110. Preparation of 1,4-disubstituted-1,2,3-triazolo ribonucleosides by Na2CuP2O7 catalyzed azide-alkyne 1,3-dipolar cycloaddition.
Elayadi, H.; Mesnaoui, M.; Korba, B. E.; Smietana, M.; Vasseur, J. J.; Secrist, J. A.; Lazrek, H. B.
Arkivoc 2012, 76-89. https://10.3998/ark.5550190.0013.807.
109. Borononucleotides as Substrates/Binders for Human NMP Kinases: Enzymatic and Spectroscopic Evaluation.
El Amri, C.; Martin, A. R.; Vasseur, J. J.; Smietana, M.
ChemBioChem 2012, 13 (11), 1605-1612. https://10.1002/cbic.201200199.
108. An innovative strategy for sulfopeptides analysis using MALDI-TOF MS reflectron positive ion mode.
Cantel, S.; Brunel, L.; Ohara, K.; Enjalbal, C.; Martinez, J.; Vasseur, J. J.; Smietana, M.
Proteomics 2012, 12 (14), 2247-2257. https://10.1002/pmic.201100525.
107. Measurement of Enzymatic Activity and Specificity of Human and Avian Influenza Neuraminidases from Whole Virus by Glycoarray and MALDI-TOF Mass Spectrometry.
Pourceau, G.; Chevolot, Y.; Goudot, A.; Giroux, F.; Meyer, A.; Moules, V.; Lina, B.; Cecioni, S.; Vidal, B.; Yu, H.; Chen, X.; Ferraris, O.; Praly, J. P.; Souteyrand, E.; Vasseur, J. J.; Morvan, F.
ChemBioChem 2011, 12 (13), 2071-2080. https://10.1002/cbic.201100128.
106. Regioselective Synthesis of 3-Carbo-5-phosphonylpyrazoles through a One-Pot Claisen-Schmidt/1,3-Dipolar Cycloaddition/Oxidation Sequence.
Martin, A. R.; Mohanan, K.; Toupet, L.; Vasseur, J. J.; Smietana, M.
Eur. J. Org. Chem. 2011, 2011 (17), 3184-3190. https://10.1002/ejoc.201100167.
105. Dynamic and Programmable DNA-Templated Boronic Ester Formation.
Martin, A. R.; Barvik, I.; Luvino, D.; Smietana, M.; Vasseur, J. J.
Angew. Chem. Inter. Ed. 2011, 50 (18), 4193-4196. https://10.1002/anie.201007170.
104. Synthesis and Preliminary Evaluation of pro-RNA 2 ‘-O-Masked with Biolabile Pivaloyloxymethyl Groups in an RNA Interference Assay.
Lavergne, T.; Baraguey, C.; Dupouy, C.; Parey, N.; Wuensche, W.; Sczakiel, G.; Vasseur, J. J.; Debart, F.
J. Org. Chem. 2011, 76 (14), 5719-5731. https://10.1021/jo200826h.
103. Multiplexed binding determination of seven glycoconjugates for Pseudomonas aeruginosa Lectin I (PA-IL) using a DNA-based carbohydrate microarray.
Chevolot, Y.; Zhang, J.; Meyer, A.; Goudot, A.; Rouanet, S.; Vidal, S.; Pourceau, G.; Cloarec, J. P.; Praly, J. P.; Souteyrand, E.; Vasseur, J. J.; Morvan, F.
Chem. Commun. 2011, 47 (31), 8826-8828. https://10.1039/c1cc12428e.
102. Electrochemical detection of nucleic acids using pentaferrocenyl phosphoramidate alpha-oligonucleotides.
Chatelain, G.; Meyer, A.; Morvan, F.; Vasseur, J. J.; Chaix, C.
New J. Chem. 2011, 35 (4), 893-901. https://10.1039/c0nj00902d.
101. Efficient Solid-Phase Chemical Synthesis of 5 ‘-Triphosphates of DNA, RNA, and their Analogues.
Zlatev, I.; Lavergne, T.; Debart, F.; Vasseur, J. J.; Manoharan, M.; Morvan, F.
Org. Lett. 2010, 12 (10), 2190-2193. https://10.1021/ol1004214.
100. 3 ‘-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity.
Priet, S.; Zlatev, I.; Barvik, I.; Geerts, K.; Leyssen, P.; Neyts, J.; Dutartre, H.; Canard, B.; Vasseur, J. J.; Morvan, F.; Alvarez, K.
J. Med. Chem. 2010, 53 (18), 6608-6617. https://10.1021/jm100102v.
99. Oligonucleotide Carbohydrate-Centered Galactosyl Cluster Conjugates Synthesized by Click and Phosphoramidite Chemistries.
Pourceau, G.; Meyer, A.; Chevolot, Y.; Souteyrand, E.; Vasseur, J. J.; Morvan, F.
Bioconjugate Chem. 2010, 21 (8), 1520-1529. https://10.1021/bc1001888.
98. From Anionic to Cationic alpha-Anomeric Oligodeoxynucleotides.
Morvan, F.; Debart, F.; Vasseur, J. J.
Chem. Biodivers. 2010, 7 (3), 494-535. https://10.1002/cbdv.200900220.
97. Three-Component Reaction Using the Bestmann-Ohira Reagent: A Regioselective Synthesis of Phosphonyl Pyrazole Rings.
Mohanan, K.; Martin, A. R.; Toupet, L.; Smietana, M.; Vasseur, J. J.
Angew. Chem. Int. Ed. 2010, 49 (18), 3196-3199. https://10.1002/anie.200906781.
96. Oligonucleotide Sequential Bis-Conjugation via Click-Oxime and Click-Huisgen Procedures.
Meyer, A.; Spinelli, N.; Dumy, P.; Vasseur, J. J.; Morvan, F.; Defrancq, E.
J. Org. Chem. 2010, 75 (11), 3927-3930. https://10.1021/jo.100599m.
95. 5 ‘-Bis-conjugation of Oligonucleotides by Amidative Oxidation and Click Chemistry.
Meyer, A.; Pourceau, G.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2010, 75 (19), 6689-6692. https://10.1021/jo101134z.
94. Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors.
Elayadi, H.; Smietana, M.; Pannecouque, C.; Leyssen, P.; Neyts, J.; Vasseur, J. J.; Lazrek, H. B.
Bioorg. Med. Chem. Lett. 2010, 20 (24), 7365-7368. https://10.1016/j.bmcl.2010.10.046.
93. A Procedure for Facile Synthesis of Nucleosides Using N, O-Bistrimethylsilylacetamide in the Presence of Natural Phosphate Coated with Potassium Iodide.
Baddi, L.; Smietana, M.; Sebti, S.; Vasseur, J. J.; Lazrek, H. B.
Lett. Org. Chem. 2010, 7 (3), 196-199. https://10.2174/157017810791112441.
92. delta-Di-carboxybutyl phosphoramidate of 2 ‘-deoxycytidine-5 ‘-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase.
Zlatev, I.; Giraut, A.; Morvan, F.; Herdewijn, P.; Vasseur, J. J.
Bioorg. Med. Chem. 2009, 17 (19), 7008-7014. https://10.1016/j.bmc.2009.08.001.
91. Specific recognition of lectins by oligonucleotide glycoconjugates and sorting on a DNA microarray.
Zhang, J.; Pourceau, G.; Meyer, A.; Vidal, S.; Praly, J. P.; Souteyrand, E.; Vasseur, J. J.; Morvan, F.; Chevolot, Y.
Chem. Commun. 2009, (44), 6795-6797. https://10.1039/b915132j.
90. DNA-directed immobilisation of glycomimetics for glycoarrays application: Comparison with covalent immobilisation, and development of an on-chip IC50 measurement assay.
Zhang, J.; Pourceau, G.; Meyer, A.; Vidal, S.; Praly, J. P.; Souteyrand, E.; Vasseur, J. J.; Morvan, F.; Chevolot, Y.
Biosens. Bioelectron. 2009, 24 (8), 2515-2521. https://10.1016/j.bios.2009.01.007.
89. Synthesis of Mannose and Galactose Oligonucleotide Conjugates by Bi-click chemistry.
Pourceau, G.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2009, 74 (3), 1218-1222. https://10.1021/jo802536q.
88. Azide Solid Support for 3 ‘-Conjugation of Oligonucleotides and Their Circularization by Click Chemistry.
Pourceau, G.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2009, 74 (17), 6837-6842. https://10.1021/jo9014563.
87. NIS-promoted guanylation of amines.
Ohara, K.; Vasseur, J. J.; Smietana, M.
Tetrahedron Lett. 2009, 50 (13), 1463-1465. https://10.1016/j.tetlet.2009.01.073.
86. Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Analysis of Polysulfated-Derived Oligosaccharides Using Pyrenemethylguanidine.
Ohara, K.; Jacquinet, J. C.; Jouanneau, D.; Helbert, W.; Smietana, M.; Vasseur, J. J.
J. Am. Soc. Mass Spectrom. 2009, 20 (1), 131-137. https://10.1016/j.jasms.2008.09.004.
85. Design of Triazole-Tethered Glycoclusters Exhibiting Three Different Spatial Arrangements and Comparative Study of their Affinities towards PA-IL and RCA 120 by Using a DNA-Based Glycoarray.
Moni, L.; Pourceau, G.; Zhang, J.; Meyer, A.; Vidal, S.; Souteyrand, E.; Dondoni, A.; Morvan, F.; Chevolot, Y.; Vasseur, J. J.; Marra, A.
ChemBioChem 2009, 10 (8), 1369-1378. https://10.1002/cbic.200900024.
84. Expanding the borononucleotide family: synthesis of borono-analogues of dCMP, dGMP and dAMP.
Martin, A. R.; Mohanan, K.; Luvino, D.; Floquet, N.; Baraguey, C.; Smietana, M.; Vasseur, J. J.
Org. Biomol. Chem. 2009, 7 (21), 4369-4377. https://10.1039/b912616c.
83. Assessment of new 2 ‘-O-acetalester protecting groups for regular RNA synthesis and original
2′-modified proRNA.
Martin, A. R.; Lavergne, T.; Vasseur, J. J.; Debart, F.
Bioorg. Med. Chem. Lett. 2009, 19 (15), 4046-4049. https://10.1016/j.bmcl.2009.06.015.
82. Efficient Release of Base-Sensitive Oligonucleotides from Solid Supports using Fluoride Ions.
Lavergne, T.; Parey, N.; Vasseur, J. J.; Debart, F.
Eur. J. Org. Chem. 2009, 2009 (13), 2190-2194. https://10.1002/ejoc.200801275.
81. Deoxygenation of 5-O-benzoyl-1,2-isopropylidene-3-O-imidazolylthiocarbonyl-alpha-D-xylofu ranose using dimethyl phosphite: an efficient alternate method towards a 3′-deoxynucleoside glycosyl donor.
Zlatev, I.; Vasseur, J. J.; Morvan, F. O.
Tetrahedron Lett. 2008, 49 (20), 3288-3290. https://10.1016/j.tetlet.2008.03.079.
80. Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors.
Zlatev, I.; Dutartre, H.; Barvik, I.; Neyts, J.; Canard, B.; Vasseur, J. J.; Alvarez, K.; Morvan, F.
J. Med. Chem. 2008, 51 (18), 5745-5757. https://10.1021/jm800617c.
79. Synthesis of new N-isobutyryl-L-cysteine/MEA conjugates: Evaluation of their free radical-scavenging activities and anti-HIV properties in human macrophages.
Smietana, M.; Clayette, P.; Mialocq, P.; Vasseur, J. J.; Oiry, J.
Bioorganic Chem. 2008, 36 (1-3), 133-140. https://10.1016/j.bioorg.2008.02.001.
78. Combinatorial and automated synthesis of phosphodiester galactosyl cluster on solid support by click chemistry assisted by microwaves.
Pourceau, G.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2008, 73 (15), 6014-6017. https://10.1021/jo8009837.
77. Incorporation of oxidized guanine nucleoside 5 ‘-triphosphates in DNA with DNA polymerases and preparation of single-lesion carrying DNA.
Mourgues, S.; Trzcionka, J.; Vasseur, J. J.; Pratviel, G.; Meunier, B.
Biochemistry 2008, 47 (16), 4788-4799. https://10.1021/bi7022199.
76. Boronic acid-based fluorescent receptors for selective recognition of thymine glycol.
Luvino, D.; Gasparutto, D.; Reynaud, S.; Smietana, M.; Vasseur, J. J.
Tetrahedron Lett. 2008, 49 (42), 6075-6078. https://10.1016/j.tetlet.2008.07.173.
75. Borononucleotides: synthesis, and formation of a new reversible boronate internucleosidic linkage.
Luvino, D.; Baraguey, C.; Smietana, M.; Vasseur, J. J.
Chem. Commun. 2008, (20), 2352-2354. https://10.1039/b802098a.
74. New strategies for cyclization and bicyclization of oligonucleotides by click chemistry assisted by microwaves.
Lietard, J.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2008, 73 (1), 191-200. https://10.1021/jo702177c.
73. A Base-Labile Group for 2 ‘-OH Protection of Ribonucleosides: A Major Challenge for RNA Synthesis.
Lavergne, T.; Bertrand, J. R.; Vasseur, J. J.; Debart, F.
Chem. Eur. J. 2008, 14 (30), 9135-9138. https://10.1002/chem.200801392.
72. Convenient synthesis of N-2-isobutyryl-2′-O-methyl guanosine by efficient alkylation of O-6-trimethylsilylethyl-3′,5′-di-tert-butylsilanediyl guanosine.
Zlatev, I.; Vasseur, J. J.; Morvan, F.
Tetrahedron 2007, 63 (45), 11174-11178. https://10.1016/j.tet.2007.08.006.
71. High-yield production of short GpppA- and (7Me)GpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2 ‘ O positions.
Peyrane, F.; Selisko, B.; Decroly, E.; Vasseur, J. J.; Benarroch, D.; Canard, B.; Alvarez, K.
Nucleic Acids Res. 2007, 35 (4), 11. https://10.1093/nar/gkl1119.
70. Amine-guanidine switch: A promising approach to improve DNA binding and antiproliferative activities.
Ohara, K.; Smietana, M.; Restouin, A.; Mollard, S.; Borg, J. P.; Collette, Y.; Vasseur, J. J.
J. Med. Chem. 2007, 50 (26), 6465-6475. https://10.1021/jm701207m.
69. Synthesis and biological evaluation of some alpha- 6-(1 ‘-carbamoylalkylthio)-1H-pyrazolo 3,4-D pyrimidin-4-yl thioalkylcarboxam ide acyclonucleosides.
Moukha-Chafiq, O.; Taha, M. L.; Mouna, A.; Lazrek, H. B.; Vasseur, J. J.
Nucleosides Nucleotides Nucleic Acids 2007, 26 (4), 335-345. https://10.1080/15257770701296952.
68. Fucosylated pentaerythrityl phosphodiester oligomers (PePOs): Automated synthesis of DNA-Based glycoclusters and binding to Pseudomonas aeruginosa lectin (PA-IIL).
Morvan, F.; Meyer, A.; Jochum, A.; Sabin, C.; Chevolot, Y.; Imberty, A.; Praly, J. P.; Vasseur, J. J.; Souteyrand, E.; Vidal, S.
Bioconjugate Chem. 2007, 18 (5), 1637-1643. https://10.1021/bc070129z.
67. Sequential Seyferth-Gilbert/CuAAC reactions: Application to the one-pot synthesis of triazoles from aldehydes.
Luvino, D.; Amalric, C.; Smietana, M.; Vasseur, J. J.
Synlett 2007, (19), 3037-3041. https://10.1055/s-2007-990877.
66. An efficient reagent for 5 ‘-azido oligonucleotide synthesis.
Lietard, J.; Meyer, A.; Vasseur, J. J.; Morvan, F.
Tetrahedron Lett. 2007, 48 (50), 8795-8798. https://10.1016/j.tetlet.2007.10.081.
65. Conformational and chiral selection of oligonucleotides.
Froeyen, M.; Morvan, F.; Vasseur, J. J.; Nielsen, P.; Van Aerschot, A.; Rosemeyer, H.; Herdewijn, P.
Chem. Biodivers. 2007, 4 (4), 803-817. https://10.1002/cbdv.200790065.
64. 5-Propynylamino alpha-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic alpha-oligonucleotides.
Deglane, G.; Morvan, F.; Debart, F.; Vasseur, J. J.
Bioorg. Med. Chem. Lett. 2007, 17 (4), 951-954. https://10.1016/j.bmcl.2006.11.052.
63. Chemical modifications to improve the cellular uptake of oligonucleotides.
Debart, F.; Abes, S.; Deglane, G.; Moulton, H. M.; Clair, P.; Gait, M. J.; Vasseur, J. J.; Lebleu, B.
Curr. Top. Med. Chem. 2007, 7 (7), 727-737. https://10.2174/156802607780487704.
62. DNA-based carbohydrate biochips: A platform for surface glyco-engineering.
Chevolot, Y.; Bouillon, C.; Vidal, S.; Morvan, F.; Meyer, A.; Cloarec, J. P.; Jochum, A.; Praly, J. P.; Vasseur, J. J.; Souteyrand, E.
Angew. Chem. Int. Ed. 2007, 46 (14), 2398-2402. https://10.1002/anie.200604955.
61. Use of a solid-supported coupling reagent for a selective phosphitylation of the primary alcohol of N-2-isobutyryl-2 ‘-deoxy or 2 ‘-O-methyl guanosine.
Zlatev, I.; Kato, Y.; Meyer, A.; Vasseur, J. J.; Morvan, F.
Tetrahedron Lett. 2006, 47 (47), 8379-8382. https://10.1016/j.tetlet.2006.09.086.
60. First evaluation of acyloxymethyl or acylthiomethyl groups as biolabile 2 ‘-O-protections of RNA.
Parey, N.; Baraguey, C.; Vasseur, J. J.; Debart, F.
Org. Lett. 2006, 8 (17), 3869-3872. https://10.1021/ol0616182.
59. Characterization of specific noncovalent complexes between guanidinium derivatives and single-stranded DNA by MALDI.
Ohara, K.; Smietana, M.; Vasseur, J. J.
J. Am. Soc. Mass Spectrom. 2006, 17 (3), 283-291. https://10.1016/j.jasms.2005.11.005.
58. Synthesis and antiviral activity of some C-2-, C-4-, and C-6-substituted pyrazolo 3,4-D pyrimidine acyclonucleosides with the alkylating chains of ACV, HBG, and ISO-DHPG.
Moukha-chafiq, O.; Taha, M. L.; Lazrek, H. B.; Vasseur, J. J.; De Clercq, E.
Nucleosides Nucleotides Nucleic Acids 2006, 25 (8), 849-860. https://10.1080/15257770600793802.
57. A versatile reagent for the synthesis of 5 ‘-phosphorylated, 5 ‘-thiophosphorylated or 5 ‘-phosphoramidate-conjugated oligonucleotides.
Meyer, A.; Bouillon, C.; Vidal, S.; Vasseur, J. J.; Morvan, F.
Tetrahedron Lett. 2006, 47 (50), 8867-8871. https://10.1016/j.tetlet.2006.10.049.
56. Selective fluorescence-based detection of dihydrouridine with boronic acids.
Luvino, D.; Smietana, M.; Vasseur, J. J.
Tetrahedron Lett. 2006, 47 (52), 9253-9256. https://10.1016/j.tetlet.2006.10.150.
55. A one-pot synthesis of D-ribonucleosides using natural phosphate doped with KI in HMDS.
Lazrek, H. B.; Ouzebla, D.; Rochdi, A.; Redwane, N.; Vasseur, J. J.
Lett. Org. Chem. 2006, 3 (4), 313-314. https://10.2174/157017806776114531.
54. Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding – Role of DNA backbone flexibility and an open catalytic site.
Johnson, A. A.; Sayer, J. M.; Yagi, H.; Patil, S. S.; Debart, F.; Maier, M. A.; Corey, D. R.; Vasseur, J. J.; Burke, T. R.; Marquez, V. E.; Jerina, D. M.; Pommier, Y.
J. Biol. Chem. 2006, 281 (43), 32428-32438. https://10.1074/jbc.M605101200.
53. Impact of the guanidinium group on hybridization and cellular uptake of cationic oligonucleotides.
Deglane, G.; Abes, S.; Michel, T.; Prevot, P.; Vives, E.; Debart, F.; Barvik, I.; Lebleu, B.; Vasseur, J. J.
ChemBioChem 2006, 7 (4), 684-692. https://10.1002/cbic.200500433.
52. Microwave assisted “click” chemistry for the synthesis of multiple labeled-carbohydrate oligonucleotides on solid support.
Bouillon, C.; Meyer, A.; Vidal, S.; Jochum, A.; Chevolot, Y.; Cloarec, J. P.; Praly, J. P.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2006, 71 (12), 4700-4702. https://10.1021/jo060572n.
51. Solution-phase synthesis of phosphorothioate oligonucleotides using a solid-supported acyl chloride with H-phosphonate chemistry.
Adamo, I.; Dueymes, U.; Schonberger, A.; Navarro, A. E.; Meyer, A.; Lange, M.; Imbach, J. L.; Link, F.; Morvan, F.; Vasseur, J. J.
Eur. J. Org. Chem. 2006, 2006 (2), 436-448. https://10.1002/ejoc.200500547.
50. Highly stable DNA triplexes formed with cationic phosphoramidate pyrimidine alpha-oligonucleotides.
Michel, T.; Debart, F.; Heitz, F.; Vasseur, J. J.
ChemBioChem 2005, 6 (7), 1254-1262. https://10.1002/cbic.200400436.
49. Toward high yield synthesis of peptide-oligonucleotide chimera through a disulfide bridge: A simplified method for oligonucleotide activation.
Maurel, F.; Debart, F.; Cavelier, F.; Thierry, A. R.; Lebleu, B.; Vasseur, J. J.; Vives, E.
Bioorg. Med. Chem. Lett. 2005, 15 (22), 5084-5087. https://10.1016/j.bmcl.2005.07.086.
48. Optimized synthesis of functionalized fluorescent oligodeoxynucleotides for protein labeling.
Goussu, C.; Vasseur, J. J.; Bazin, H.; Trinquet, E.; Maurin, F.; Morvan, F.
Bioconjugate Chem. 2005, 16 (2), 465-470. https://10.1021/bc049752z.
47. Universal solid supports for the synthesis of oligonucleotides via a transesterification of H-phosphonate diester linkage.
Ferreira, F.; Meyer, A.; Vasseur, J. J.; Morvan, F.
J. Org. Chem. 2005, 70 (23), 9198-9206. https://10.1021/jo051172n.
46. High-yield solution-phase synthesis of Di- and trinucleotide blocks assisted by polymer-supported reagents.
Dueymes, C.; Schonberger, A.; Adamo, I.; Navarro, A. E.; Meyer, A.; Lange, M.; Imbach, J. L.; Link, F.; Morvan, F.; Vasseur, J. J.
Org. Lett. 2005, 7 (16), 3485-3488. https://10.1021/ol0511777.
45. Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity.
Taourirte, M.; Mohamed, L. A.; Rochdi, A.; Vasseur, J. J.; Fernandez, S.; Ferrero, M.; Gotor, V.; Pannecouque, C.; De Clercq, E.; Lazrek, H. B.
Nucleosides Nucleotides Nucleic Acids 2004, 23 (4), 701-714. https://10.1081/ncn-120037749.
44. H-Phosphonate oligonucleotides from phosphoramidite chemistry.
Meyer, A.; Morvan, F.; Vasseur, J. J.
Tetrahedron Lett. 2004, 45 (19), 3745-3748. https://10.1016/j.tetlet.2004.03.093.
43. Lewis acid deprotection of silyl-protected oligonucleotides and base-sensitive oligonucleotide analogues.
Ferreira, F.; Vasseur, J. J.; Morvan, F.
Tetrahedron Lett. 2004, 45 (33), 6287-6290. https://10.1016/j.tetlet.2004.06.081.
42. Cationic phosphoramidate alpha-oligonucleotides efficiently target single-stranded DNA and RNA and inhibit hepatitis C virus IRES-mediated translation.
Michel, T.; Martinand-Mari, C.; Debart, F.; Lebleu, B.; Robbins, I.; Vasseur, J. J.
Nucleic Acids Res. 2003, 31 (18), 5282-5290. https://10.1093/nar/gkg733.
41. FTIR and UV spectroscopy studies of triplex formation between alpha-oligonucleotides with non-ionic phoshoramidate linkages and DNA targets.
Michel, T.; Debart, F.; Vasseur, J. J.; Geinguenaud, F.; Taillandier, E.
J. Biomol. Struct. Dyn. 2003, 21 (3), 435-445. https://10.1080/07391102.2003.10506938.
40. Efficient guanidination of the phosphate linkage towards cationic phosphoramidate oligonucleotides.
Michel, T.; Debart, F.; Vasseur, J. J.
Tetrahedron Lett. 2003, 44 (35), 6579-6582. https://10.1016/s0040-4039(03)01694-0.
39. FTIR and UV spectroscopy studies of triplex formation between pyrimidine methoxyethylphosphoramidates alpha-oligodeoxynucleotides and ds DNA targets.
Sun, B. W.; Geinguenaud, F.; Taillandier, E.; Naval, M.; Laurent, A.; Debart, F.; Vasseur, J. J.
J. Biomol. Struct. Dyn. 2002, 19 (6), 1073-1081. https://10.1080/07391102.2002.10506810.
38. Use of allylic protecting groups for the synthesis of base-sensitive prooligonucleotides.
Spinelli, N.; Meyer, A.; Hayakawa, Y.; Imbach, J. L.; Vasseur, J. J.
Eur. J. Org. Chem. 2002, 2002 (1), 49-56. https://doi.org/10.1002/1099-0690(20021)2002:1%3C49::AID-EJOC49%3E3.0.CO;2-7.
37. 2-Amino-alpha-2 ‘-deoxyadenosine increased duplex stability of methoxyethylphosphoramidate alpha-oligodeoxynucleotides with RNA target.
Naval, M.; Michel, T.; Vasseur, J. J.; Debart, F.
Bioorg. Med. Chem. Lett. 2002, 12 (11), 1435-1438. https://10.1016/s0960-894x(02)00215-9.
36. Synthesis and biological activity of some 4-substituted 1- 1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4&5)-ylmethyl -1H-py razolo 3,4-d pyrimidines.
Moukha-chafiq, O.; Taha, M. L.; Lazrek, H. B.; Vasseur, J. J.; Pannecouque, C.; Witvrouw, M.; De Clercq, E.
Farmaco 2002, 57 (1), 27-32. https://10.1016/s0014-827x(01)01152-1.
35. Synthesis and biological evaluation of some acyclic alpha-(1H-pyrazolo 3,4-d pyrimidin-4-yl)thioalkylamide nucleosides.
Moukha-Chafiq, O.; Taha, M. L.; Lazrek, H. B.; Vasseur, J. J.; De Clercq, E.
Nucleosides Nucleotides Nucleic Acids 2002, 21 (2), 165-176. https://10.1081/ncn-120003180.
34. Use of MALDI-TOF mass spectrometry to monitor solid-phase synthesis of oligonucleotides.
Guerlavais, T.; Meyer, A.; Debart, F.; Imbach, J. L.; Morvan, F.; Vasseur, J. J.
Anal. Bioanal. Chem. 2002, 374 (1), 57-63. https://10.1007/s00216-002-1395-7.
33. Synthesis and biological evaluation of some 4-substituted 1- 1-(4-hydroxybutyl)-1,2,3-triazol-(4&5)-ylmethyl 1H-pyrazolo- 3,4-d py rimidines.
Moukha-Chafiq, O.; Taha, M. L.; Lazrek, H. B.; Vasseur, J. J.; Pannecouque, C.; Witvrouw, M.; De Clercq, E.
Nucleosides Nucleotides Nucleic Acids 2001, 20 (10-11), 1811-1821. https://10.1081/ncn-100107192.
32. Kinetics study of the biotransformation of an oligonucleotide prodrug in cells extract by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry.
Bres, J. C.; Morvan, F.; Lefebvre, I.; Vasseur, J. J.; Pompon, A.; Imbach, J. L.
J. Chromatogr. B 2001, 753 (1), 123-130. https://10.1016/s0378-4347(00)00502-8.
31. Prooligonucleotides exhibit less serum-protein binding than phosphodiester and phosphorothioate oligonucleotides.
Tosquellas, G.; Bryksin, A.; Alvarez, K.; Morvan, F.; Vasseur, J. J.; Rayner, B.; Rykova, E.; Laktionov, P.; Vlassov, V.; Imbach, J. L.
Nucleosides Nucleotides Nucleic Acids 2000, 19 (5-6), 995-1003. https://10.1080/15257770008033038.
30. Analysis of solid-supported oligonucleotides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Meyer, A.; Spinelli, N.; Imbach, J. L.; Vasseur, J. J.
Rapid Commun. Mass Spectrom. 2000, 14 (4), 234-242. https://10.1002/(sici)1097-0231(20000229)14:4<234::aid-rcm874>3.0.co;2-1.
29. Prooligonucleotide metabolism in a crude cell extract followed by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry.
Lioux, T.; Lefebvre, I.; Vasseur, J. J.; Imbach, J. L.
Rapid Commun. Mass Spectrom. 1999, 13 (16), 1645-1649. https://10.1002/(sici)1097-0231(19990830)13:16<1645::aid-rcm692>3.0.co;2-y.
28. Chiral and steric effects in the efficient binding of alpha-anomeric deoxyoligonucleoside N-alkylphosphoramidates to ssDNA and RNA.
Laurent, A.; Naval, M.; Debart, F.; Vasseur, J. J.; Rayner, B.
Nucleic Acids Res. 1999, 27 (21), 4151-4159. https://10.1093/nar/27.21.4151.
27. Photocleavable protecting groups as nucleobase protections allowed the solid-phase synthesis of base-sensitive SATE-prooligonucleotides.
Alvarez, K.; Vasseur, J. J.; Beltran, T.; Imbach, J. L.
J. Org. Chem. 1999, 64 (17), 6319-6328. https://10.1021/jo990479h.
26. The pro-oligonucleotide approach: solid phase synthesis and preliminary evaluation of model pro-dodecathymidylates.
Tosquellas, G.; Alvarez, K.; Dell’Aquila, C.; Morvan, F.; Vasseur, J. J.; Imbach, J. L.; Rayner, B.
Nucleic Acids Res. 1998, 26 (9), 2069-2074. https://10.1093/nar/26.9.2069.
25. Anomeric inversion (from beta to alpha) in methylphosphonate oligonucleosides enhances their affinity for DNA and RNA.
Debart, F.; Meyer, A.; Vasseur, J. J.; Rayner, B.
Nucleic Acids Res. 1998, 26 (20), 4551-4556. https://10.1093/nar/26.20.4551.
24. A reinvestigation of sulfenyl groups as amino protecting groups for the synthesis of oligonucleotides on solid support by phosphoramidite chemistry.
Alvarez, K.; Tworkowski, I.; Vasseur, J. J.; Imbach, J. L.; Rayner, B.
Nucleosides Nucleotides Nucleic Acids 1998, 17 (1-3), 365-378. https://10.1080/07328319808005184.
23. Oligodeoxynucleoside phosphoramidates (P-NH2): Synthesis and thermal stability of duplexes with DNA and RNA targets.
Peyrottes, S.; Vasseur, J. J.; Imbach, J. L.; Rayner, B.
Nucleic Acids Res. 1996, 24 (10), 1841-1848. https://10.1093/nar/24.10.1841.
22. Dramatic effect of the anomeric configuration on the thermal stability of duplex formed between novel dodecathymidine phosphoramidate (P-NH2) and complementary DNA and RNA strands.
Peyrottes, S.; Vasseur, J. J.; Imbach, J. L.; Rayner, B.
Tetrahedron Lett. 1996, 37 (33), 5869-5872. https://10.1016/0040-4039(96)01250-6.
21. Oligonucleotide mimics for antisense therapeutics: Solution phase and automated solid-support synthesis of MMI linked oligomers.
Morvan, F.; Sanghvi, Y. S.; Perbost, M.; Vasseur, J. J.; Bellon, L.
J. Am. Chem. Soc. 1996, 118 (1), 255-256. https://10.1021/ja9533959.
20. An easy access of 2′,3′-dideoxy-3′-alpha-C-formyl-adenosine and 2′,3′-dideoxy-3′-alpha-C-formyl-guanosine analogs via stereoselective C-C bond-forming radical reaction.
Sanghvi, Y. S.; Ross, B.; Bharadwaj, R.; Vasseur, J. J.
Tetrahedron Lett. 1994, 35 (27), 4697-4700. https://10.1016/s0040-4039(00)76944-9.
19. Synthesis, base-pairing properties and nuclease resistance of oligothymidylate analogs containing methoxyphosphoramidate internucleoside linkages.
Peyrottes, S.; Vasseur, J. J.; Imbach, J. L.; Rayner, B.
Nucleosides Nucleotides 1994, 13 (10), 2135-2149. https://10.1080/15257779408013213.
18. Oligonucleosides – synthesis of a novel methylhydroxylamine-linked nucleoside dimer and its incorporation into antisense sequences.
Vasseur, J. J.; Debart, F.; Sanghvi, Y. S.; Cook, P. D.
J. Am. Chem. Soc. 1992, 114 (10), 4006-4007. https://10.1021/ja00036a076.
17. 9-Aminoellipticine-derivatized alpha- and beta-oligodeoxyribonucleotides targeted to the cap of beta-globin mRNA: hybridization to natural and engineered mRNA, inhibition of translation, and improved effect of tandem chains
Porumb, H.; Bertrand, J.-R.; Paoletti, J.; Vasseur, J. J.; Rayner, B.; Imbach, J.-L.; Malvy, C.
Antisense Res. Dev. 1992, 2 (4), 279-292. https://doi.org/10.1089/ard.1992.2.279.
16. Intermolecular radical C-C bond formation – synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides.
Debart, F.; Vasseur, J. J.; Sanghvi, Y. S.; Cook, P. D.
Tetrahedron Lett. 1992, 33 (19), 2645-2648. https://10.1016/s0040-4039(00)79047-2.
15. Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides.
Debart, F.; Vasseur, J. J.; Sanghvi, Y. S.; Cook, P. D.
Bioorg. Med. Chem. Lett. 1992, 2 (12), 1479-1482. https://10.1016/s0960-894x(00)80412-6.
14. Derivatization of oligonucleotides through abasic site formation.
Vasseur, J. J.; Peoch, D.; Rayner, B.; Imbach, J. L.
Nucleosides Nucleotides 1991, 10 (1-3), 107-117. https://10.1080/07328319108046439.
13. Polarity of annealing and structural-analysis of the RNase H resistant alpha-5′-d TACACA .Beta-5′-r AUGUGU hybrid determined by high-field H-1, C-13, and P-31 NMR analysis.
Gmeiner, W. H.; Rao, K. E.; Rayner, B.; Vasseur, J. J.; Morvan, F.; Imbach, J. L.; Lown, J. W.
Biochemistry 1990, 29 (45), 10329-10341. https://10.1021/bi00497a007.
12. Mutagenic properties of a unique abasic site in mammalian-cells.
Gentil, A.; Renault, G.; Madzak, C.; Margot, A.; Cabralneto, J. B.; Vasseur, J. J.; Rayner, B.; Imbach, J. L.; Sarasin, A.
Biochem. Biophys. Res. Commun. 1990, 173 (2), 704-710. https://10.1016/s0006-291x(05)80092-0.
11. Synthesis, thermal-stability and reactivity towards 9-aminoellipticine of double-stranded oligonucleotides containing a true abasic site.
Bertrand, J. R.; Vasseur, J. J.; Rayner, B.; Imbach, J. L.; Paoletti, J.; Paoletti, C.; Malvy, C.
Nucleic Acids Res. 1989, 17 (24), 10307-10319. https://10.1093/nar/17.24.10307.
10. Mechanism of cleavage of apurinic sites by 9-aminoellipticine.
Bertrand, J. R.; Vasseur, J. J.; Gouyette, A.; Rayner, B.; Imbach, J. L.; Paoletti, C.; Malvy, C.
J. Biol. Chem. 1989, 264 (24), 14172-14178. https://doi.org/10.1016/S0021-9258(18)71658-X.
9. Apurinic DNA reactivity – modelization of apurinic DNA breakage with phenylhydrazine and formation of a pyrazole adduct.
Vasseur, J. J.; Rayner, B.; Imbach, J. L.
J. Heterocycl. Chem. 1988, 25 (2), 389-392. https://10.1002/jhet.5570250207.
8. Efficient and easy synthesis of octathymidylate covalently linked to intercalating 9-aminoellipticine.
Vasseur, J. J.; Gauthier, C.; Rayner, B.; Paoletti, J.; Imbach, J. L.
Biochem. Biophys. Res. Commun. 1988, 152 (1), 56-61. https://10.1016/s0006-291x(88)80679-x.
7. Structure of the adduct formed between 3-aminocarbazole and the apurinic site oligonucleotide model d Tp(ap)pT.
Vasseur, J. J.; Rayner, B.; Imbach, J. L.; Verma, S.; McCloskey, J. A.; Lee, M.; Chang, D. K.; Lown, J. W.
J. Org. Chem. 1987, 52 (22), 4994-4998. https://10.1021/jo00231a028.
6. Preparation of a short synthetic apurinic oligonucleotide.
Vasseur, J. J.; Rayner, B.; Imbach, J. L.
Biochem. Biophys. Res. Commun. 1986, 134 (3), 1204-1208. https://10.1016/0006-291x(86)90378-5.
5. H-1-NMR assignments of the non-exchangeable protons of the consensus donor exon-intron junction d(CpApGpGpTpApApGpT).
Lown, J. W.; Hanstock, C. C.; Imbach, J. L.; Rayner, B.; Vasseur, J. J.
J. Biomol. Struct. Dyn. 1985, 2 (6), 1125-1135. https://10.1080/07391102.1985.10507628.
4. Synthesis, complete H-1 assignments and conformations of the self-complementary hexadeoxyribonucleotide d(CpGpApTpCpG)2 and its fragments by high-field NMR.
Lown, J. W.; Hanstock, C. C.; Bleackley, R. C.; Imbach, J. L.; Rayner, B.; Vasseur, J. J.
Nucleic Acids Res. 1984, 12 (5), 2519-2533. https://10.1093/nar/12.5.2519.
3. New lipophilic phosphate protecting group for the synthesis of oligonucleotides.
Vasseur, J. J.; Rayner, B.; Imbach, J. L.
Tetrahedron Lett. 1983, 24 (27), 2753-2756. https://10.1016/s0040-4039(00)88013-2.
2. Use of inter-proton nuclear overhauser effects to assign the nuclear magnetic-resonance spectra of oligodeoxynucleotide and hybrid duplexes in aqueous-solution.
Reid, D. G.; Salisbury, S. A.; Brown, T.; Williams, D. H.; Vasseur, J. J.; Rayner, B.; Imbach, J. L.
Eur. J. Biochem. 1983, 135 (2), 307-314. https://10.1111/j.1432-1033.1983.tb07654.x.
1. Synthesis of RNA oligonucleotides for use in the study of protein-synthesis.
Vasseur, J. J.; Rayner, B.; Pompon, A.; Imbach, J. L.
New J. Chem. 1981, 5 (5-6), 343-347. https://hal.archives-ouvertes.fr/hal-03726090.