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87. Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases
M. Hausdorff, A. Delpal, S. Barelier, L. Nicollet, B. Canard, F. Touret, A. Colmant, B. Coutard, J.-J. Vasseur, E. Decroly, F. Debart.
Eur. J. Med. Chem., 2023, 256, 115474.
86. AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5
Feracci, M., Eydoux, C., Fattorini, V., Lo Bello, L., Gauffre, P., Selisko, B., Sutto-Ortiz, P., Shannon, A., Xia, H., Shi, P.-Y., Noel, M., Debart, F., Vasseur, J.-J., Good, S., Lin, K., Moussa, A., Sommadossi, J.-P., Chazot, A., Alvarez, K., Guillemot, J.-C., Decroly, E., Ferron, F., Canard, B.
Antiviral Res., 2023, 105574.
85. Internal RNA 2’O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect
El Kazzi, P., Rabah, N., Chamontin, C., Poulain, L., Ferron, F., Debart, F., Canard, B., Missé, D., Coutard, B., Nisole, S. et al.
Nucleic Acids Res., 2023, 51, 2501-2515.
84. Importance of RNA length for in vitro encapsidation by the nucleoprotein of human Respiratory Syncytial Virus
Gonnin, L., Richard, C.-A., Gutsche, I., Chevret, D., Troussier, J., Vasseur, J.-J., Debart, F., Eléouët, J.-F. and Galloux, M.
J. Biol. Chem., 2022, 298, 102337.
83. A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome
A. Shannon, B. Sama, P. Gauffre, T. Guez, F. Debart, J.-J. Vasseur, E. Decroly, B. Canard, F. Ferron
Nucleic Acid Research, 2022, 50, 11186–11198
82. Facile access to 4′-(N-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N7-guanine-methyltransferase nsp14
R. Amador, A. Delpal, B. Canard, J.-J. Vasseur, E. Decroly, F. Debart, G. Clavé,* M. Smietana*
Organic Biomolecular Chemistry, 2022, 20, 7582-7586.
81. Direct Access to Unique C-5’-Acyl Modified Nucleosides through Liebeskind–Srogl Cross-Coupling Reaction.
Maverick, M. A.; Gaillard, M.; Vasseur, J.-J.; Debart, F.; Smietana, M.
Eur. J. Org. Chem. 2022, (21), e202101061. https://doi.org/10.1002/ejoc.202101061.
80. Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues.
Ahmed-Belkacem, R.; Hausdorff, M.; Delpal, A.; Sutto-Ortiz, P.; Colmant, A. M. G.; Touret, F.; Ogando, N. S.; Snijder, E. J.; Canard, B.; Coutard, B.; Vasseur, J.-J.; Decroly, E.; Debart, F.
J. Med. Chem. 2022, 65 (8), 6231-6249. https://doi.org/10.1021/acs.jmedchem.2c00120.
79. Bisubstrate Strategies to Target Methyltransferases.
Ahmed-Belkacem, R.; Debart, F.; Vasseur, J.-J.
Eur. J. Org. Chem. 2022, 22 (21), e202101481. https://doi.org/10.1002/ejoc.202101481.
78. First insights into the structural features of Ebola virus methyltransferase activities.
Valle, C.; Martin, B.; Ferron, F.; Roig-Zamboni, V.; Desmyter, A.; Debart, F.; Vasseur, J.-J.; Canard, B.; Coutard, B.; Decroly, E.
Nucleic Acids Res. 2021, 49 (3), 1737-1748. https://doi.org/10.1093/nar/gkaa1276.
77. The methyltransferase domain of the Respiratory Syncytial Virus L protein induces cap N7 and 2’O-methylation.
Sutto-Ortiz, P.; Tcherniuk, S.; Ysebaert, N.; Abeywickrema, P.; Noël, M.; Debart, F.; Vasseur, J.-J.; Canard, B.; Eleouët, J.-F.; Roymans, D.; Rigaux, P.; Decroly, E.
PLoS Path. 2021, 17 (5), e1009562. https://doi.org/10.1371/journal.ppat.1009562.
76. Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527.
Shannon, A.; Fattorini, V.; Sama, B.; Selisko, B.; Feracci, M.; Falcou, C.; Gauffre, P.; Kazzi, P. E.; Decroly, E.; Rabah, N.; Alvarez, K.; Eydoux, C.; Guillemot, J.-C.; Debart, F.; Vasseur, J.-J.; Noel, M.; Moussa, A.; Good, S.; Lin, K.; Sommadossi, J.-P.; Zhu, Y.; Yan, X.; Shi, H.; Ferron, F.; Canard, B.
bioRxiv 2021. https://doi.org/10.1101/2021.03.23.436564.
75. FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell.
Relier, S.; Ripoll, J.; Guillorit, H.; Amalric, A.; Boissière, F.; Vialaret, J.; Attina, A.; Debart, F.; Choquet, A.; Macari, F.; Samalin, E.; Vasseur, J.-J.; Pannequin, J.; Crapez, E.; Hirtz, C.; Rivals, E.; Bastide, A.; David, A.
Nat. Commun. 2021, 12, 1716. https://doi.org/10.1038/s41467-021-21758-4
74. The C-terminal domain of the Sudan ebolavirus L protein is essential for RNA binding and methylation.
Valle, C.; Martin, B.; Debart, F.; Vasseur, J.-J.; Imbert, I.; Canard, B.; Coutard, B.; Decroly, E.,
J. Virol. 2020, 94 (12), e00520-20. https://doi.org/10.1128/jvi.00520-20.
73. FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell.
Relier, S.; Ripoll, J.; Guillorit, H.; Amalric, A.; Boissière, F.; Vialaret, J.; Attina, A.; Debart, F.; Choquet, A.; Macari, F.; Samalin, E.; Vasseur, J.-J.; Pannequin, J.; Crapez, E.; Hirtz, C.; Rivals, E.; Bastide, A.; David, A.
bioRxiv 2020. https://doi.org/10.1101/2020.01.09.899724.
72. Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers.
Gauthier, F.; Bertrand, J.-R.; Vasseur, J.-J.; Dupouy, C.; Debart, F.
Molecules 2020, 25 (11), 2714. https://doi.org/10.3390/molecules25112714.
71. Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase.
Ahmed-Belkacem, R.; Sutto-Ortiz, P.; Guiraud, M.; Canard, B.; Vasseur, J.-J.; Decroly, E.; Debart, F.
Eur. J. Med. Chem. 2020, 201, 112557. https://doi.org/10.1016/j.ejmech.2020.112557.
70. Combining chemical synthesis and enzymatic methylation to access short RNAs with various 5′ caps.
Muthmann, N.; Guez, T.; Vasseur, J.-J.; Jaffrey, S. R.; Debart, F.; Rentmeister, A.
ChemBioChem 2019, 20, doi:10.1002/cbic.201900037. https://doi.org/doi:10.1002/cbic.201900037.
69. FTO controls reversible m6Am RNA methylation during snRNA biogenesis.
Mauer, J.; Sindelar, M.; Despic, V.; Guez, T.; Hawley, B. R.; Vasseur, J.-J.; Rentmeister, A.; Gross, S. S.; Pellizzoni, L.; Debart, F.; Goodarzi, H.; Jaffrey, S. R.
Nature Chem. Biol. 2019, 340-347. https://doi.org/10.1038/s41589-019-0231-8.
68. Conjugation of small molecules to RNA using a reducible disulfide linker attached at 2’OH position via a carbamate function.
Gauthier, F.; Malher, A.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Eur. J. Org. Chem. 2019, 5636-5645. https://doi.org/10.1002/ejoc.201900740.
67. Identification of the m6Am methyltransferase PCIF1 reveals the location and functions of m6Am in the transcriptome.
Boulias, K.; Toczydlowska-Socha, D.; Hawley, B. R.; Liberman-Isakov, N.; Takashima, K.; Zaccara, S.; Guez, T.; Vasseur, J.-J.; Debart, F.; Aravind, L.; Jaffrey, S. R.; Lieberman Greer, E.,
Mol. Cell 2019, 75 (3), 631-643.e8. https://doi.org/10.1016/j.molcel.2019.06.006.
66. Synthesis of adenine dinucleosides 2’,5’-bridged by sulfur-containing linkers as bisubstrate SAM analogues for viral RNA 2’-O-methyltransferases.
Ahmed-Belkacem, R.; Sutto-Ortiz, P.; Decroly, E.; Vasseur, J. J.; Debart, F.
Eur. J. Org. Chem. 2019, 6486-6495. https://doi.org/10.1002/ejoc.201901120.
65. La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region.
Philippe, L.; Vasseur, J.-J.; Debart, F.; Thoreen, C. C.
Nucleic Acids Res. 2018, 46 (3), 1457-1469. https://doi.org/10.1093/nar/gkx1237.
64. La protéine L du virus Ebola porte une nouvelle activité enzymatique impliquée dans la méthylation interne des ARN.
Martin, B.; Valle, C.; Coutard, B.; Canard, B.; Debart, F.; Decroly, E.
Medecine / sciences 2018, 34 (11), 919-921. https://doi.org/10.1051/medsci/2018230
63. The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure.
Martin, B.; Coutard, B.; Guez, T.; Paesen, G. C.; Canard, B.; Debart, F.; Vasseur, J.-J.; Grimes, J. M.; Decroly, E.
Nucleic Acids Res. 2018, 46 (15), 7902-7912. https://doi.org/10.1093/nar/gky637.
62. Gymnotic delivery and gene silencing activity of reduction-responsive siRNAs bearing lipophilic disulfide-containing modifications at 2′-position.
Gauthier, F.; Claveau, S.; Bertrand, J.-R.; Vasseur, J.-J.; Dupouy, C.; Debart, F.
Bioorg. Med. Chem. 2018, 26 (16), 4635-4643. https://doi.org/10.1016/j.bmc.2018.07.033.
61. A 2′,2′-disulfide-bridged dinucleotide conformationally locks RNA hairpins.
Gauthier, F.; Beltran, F.; Biscans, A.; Debart, F.; Dupouy, C.; Vasseur, J.-J.
Org. Biomol. Chem. 2018, 16 (17), 3181-3188. https://doi.org/10.1039/C8OB00328A.
60. Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing.
Debart, F.; Dupouy, C.; Vasseur, J. J.
Beilstein J. Org. Chem. 2018, 14, 436-469. https://doi.org/doi:10.3762/bjoc.14.32.
59. Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress.
Tamarkin-Ben-Harush, A.; Vasseur, J. J.; Debart, F.; Ulitsky, I.; Dikstein, R.
eLife 2017, 6, e21907. https://doi.org/10.7554/eLife.21907.
58. Reversible methylation of m(6)A(m) in the 5 ‘ cap controls mRNA stability.
Mauer, J.; Luo, X. B.; Blanjoie, A.; Jiao, X. F.; Grozhik, A. V.; Patil, D. P.; Linder, B.; Pickering, B. F.; Vasseur, J. J.; Chen, Q. Y.; Gross, S. S.; Elemento, O.; Debart, F.; Kiledjian, M.; Jaffrey, S. R.
Nature 2017, 541 (7637), 371-375. https://doi.org/10.1038/nature21022.
57. Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
Coutard, B.; Barral, K.; Lichiere, J.; Selisko, B.; Martin, B.; Aouadi, W.; Lombardia, M. O.; Debart, F.; Vasseur, J. J.; Guillemot, J. C.; Canard, B.; Decroly, E.
J. Virol. 2017, 91 (5), e02202-16. https://doi.org/10.1128/jvi.02202-16.
56. Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay.
Aouadi, W.; Eydoux, C.; Coutard, B.; Martin, B.; Debart, F.; Vasseur, J. J.; Contreras, J. M.; Morice, C.; Quérat, G.; Jung, M.-L.; Canard, B.; Guillemot, J.-C.; Decroly, E.
Antiviral. Res. 2017, 144 (Supplement C), 330-339. https://doi.org/10.1016/j.antiviral.2017.06.021.
55. Binding of the Methyl Donor S-Adenosyl-L-Methionine to Middle East Respiratory Syndrome Coronavirus 2 ‘-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.
Aouadi, W.; Blanjoie, A.; Vasseur, J. J.; Debart, F.; Canard, B.; Decroly, E.
J. Virol. 2017, 91 (5 ), e02217-16. https://doi.org/10.1128/jvi.02217-16.
54. A versatile post-synthetic method on a solid support for the synthesis of RNA containing reduction-responsive modifications.
Biscans, A.; Rouanet, S.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Org. Biomol. Chem. 2016, 14, 7010-7017. https://doi.org/10.1039/c6ob01272h.
53. Lipophilic 2′-O-Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery.
Biscans, A.; Bertrand, J.-R.; Dubois, J.; Rüger, J.; Vasseur, J.-J.; Sczakiel, G.; Dupouy, C.; Debart, F.
ChemBioChem 2016, 17, 2054-2062. https://doi.org/10.1002/cbic.201600317.
52. Solid-Phase Synthesis of Oligonucleotide 5′-(α-P-Thio)triphosphates and 5′-(α-P-Thio)(β,γ-methylene)triphosphates.
Thillier, Y.; Sallamand, C.; Baraguey, C.; Vasseur, J.-J.; Debart, F.
Eur. J. Org. Chem. 2015, 302-308. https://doi.org/10.1002/ejoc.201403381.
51. mRNA maturation in giant viruses: variation on a theme.
Priet, S.; Lartigue, A.; Debart, F.; Claverie, J.-M.; Abergel, C.
Nucleic Acids Res. 2015, 43 (7), 3776-3788. https://doi.org/10.1093/nar/gkv224.
50. X-ray structure and activities of an essential Mononegavirales L-protein domain.
Paesen, G. C.; Collet, A.; Sallamand, C.; Debart, F.; Vasseur, J.-J.; Canard, B.; Decroly, E.; Grimes, J. M.
Nature comm. 2015, 6, 8749. https://doi.org/10.1038/ncomms9749.
49. mRNA capping by venezuelan equine encephalitis virus nsP1: functional characterization and implications for antiviral research.
Changqing, L.; Guillén, J.; Rabah, N.; Blanjoie, A.; Debart, F.; Vasseur, J. J.; Canard, B.; Decroly, E.; Coutard, B.
J. Virol. 2015, 89 (16), 8292-8303. https://doi.org/10.1128/JVI.00599-15.
48. Synthesis, binding, nuclease resistance and cellular uptake properties of 2′-O-acetalester-modified oligonucleotides containing cationic groups.
Biscans, A.; Rouanet, S.; Bertrand, J.-R.; Vasseur, J. J.; Dupouy, C.; Debart, F.
Bioorg. Med. Chem. 2015, 23, 5360-5368. https://doi.org/10.1016/j.bmc.2015.07.054.
47. Ecological catalysis and phytoextraction: Symbiosis for future.
Escande, V.; Garoux, L.; Grison, C.; Thillier, Y.; Debart, F.; Vasseur, J.-J.; Boulanger, C.; Grison, C.
Appl. Catal., B 2014, 146, 279-288. http://dx.doi.org/10.1016/j.apcatb.2013.04.011.
46. Direct Synthesis of Partially Modified 2′-O-Pivaloyloxymethyl RNAs by a Base-Labile Protecting Group Strategy and their Potential for Prodrug-Based Gene-Silencing Applications.
Biscans, A.; Bos, M.; Martin, A. R.; Ader, N.; Sczakiel, G.; Vasseur, J.-J.; Dupouy, C.; Debart, F.
ChemBioChem 2014, 15, 2674-2679. https://doi.org/10.1002/cbic.201402382.
45. Solid-phase synthesis of 5′-triphosphate 2′-5′-oligoadenylates analogs with a 3′-O-biolabile group and their evaluation as RNase L activators and antiviral drugs.
Thillier, Y.; Stevens, S. K.; Moy, C.; Taylor, J.; Vasseur, J.-J.; Beigelman, L.; Debart, F.
Bioorg. Med. Chem. 2013, 21, 5461-5469. https://doi.org/10.1016/j.bmc.2013.06.008.
44. Metallophyte wastes and polymetallic catalysis: a promising combination in green chemistry. The illustrative synthesis of 5′-capped RNA.
Thillier, Y.; Losfeld, G.; Escande, V.; Dupouy, C.; Vasseur, J.-J.; Debart, F.; Grison, C.
RSC Adv. 2013, 3, 5204-5212. https://doi.org/10.1039/C3RA23115A.
43. The B. subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates.
Piton, J.; Larue, V.; Thillier, Y.; Dorléans, A.; Pellegrini, O.; Sierra-Gallay, I. L. d. l.; Vasseur, J.-J.; Debart, F.; Tisné, C.; Condon, C.
Proc. Natl. Acad. Sci. U. S. A. 2013, 110 (22), 8858-8863. https://doi.org/10.1073/pnas.1221510110.
42. Development of specific Dengue virus 2’-O- and N7-methyltransferase assays for antiviral drug screening.
Barral, K.; Sallamand, C.; Petzold, C.; Coutard, B.; Collet, A.; Thillier, Y.; Zimmermann, J.; Vasseur, J.-J.; Canard, B.; Rohayem, J.; Debart, F.; Decroly, E.
Antiviral. Res. 2013, 99, 292-300. https://doi.org/10.1016/j.antiviral.2013.06.001.
41. The biolabile 2′-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure.
Baraguey, C.; Lescrinier, E.; Lavergne, T.; Debart, F.; Herdewijn, P.; Vasseur, J.-J.
Org. Biomol. Chem. 2013, 11, 2638-2647. https://doi.org/10.1039/C3OB27005J.
40. Synthesis of 5′-Cap-0 and Cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N7)-methyltransferase.
Thillier, Y.; Decroly, E.; Morvan, F.; Canard, B.; Vasseur, J.-J.; Debart, F.
RNA 2012, 18, 856-868. https://doi.org/10.1261/rna.030932.111.
39. Molecular basis for nucleotide conservation at the ends of the dengue virus genome.
Selisko, B.; Potisopon, S.; Agred, R.; Priet, S.; Varlet, I.; Thillier, Y.; Sallamand, C.; Debart, F.; Vasseur, J.-J.; Canard, B.
PLoS Path. 2012, 8 (9), e1002912. https://doi.org/10.1371/journal.ppat.1002912.
38. Synthesis and preliminary evaluation of pro-RNA 2′-O-masked with biolabile pivaloyloxymethyl groups in an RNA interference assay.
Lavergne, T.; Baraguey, C.; Dupouy, C.; Parey, N.; Wuensche, W.; Sczakiel, G.; Vasseur, J.-J.; Debart, F.
J. Org. Chem. 2011, 76, 5719-5731. https://doi.org/10.1021/jo200826h.
37. Efficient Chemical Solid-Phase Synthesis of 5′-Triphosphates of DNA, RNA, and their Analogs.
Zlatev, I.; Lavergne, T.; Debart, F.; Vasseur, J.-J.; Manoharan, M.; Morvan, F.
Org. Lett. 2010, 12 (10), 2190-2193. https://doi.org/10.1021/ol1004214.
36. From Anionic to Cationic Alpha Anomeric Oligodeoxynucleodides.
Morvan, F.; Debart, F.; Vasseur, J.-J.
Chemistry & Biodiversity 2010, 7 (3), 494-535. https://doi.org/10.1002/cbdv.200900220.
35. Chemical synthesis of RNA with base-labile 2′-O-(pivaloyloxymethyl)-protected ribonucleoside phosphoramidites.
Debart, F.; Lavergne, T.; Janin, M.; Dupouy, C.; Vasseur, J.-J.
Current Protocols in Nucleic Acid Chemistry, Beaucage, S. e. a., Ed. John Wiley & Sons, Inc.: USA, 2010; Vol. 43, pp 3.19.11-13.19.27. https://doi.org/10.1002/0471142700.nc0319s43.
34. Assessment of new 2′-O-acetalester protecting groups for regular RNA synthesis and original 2′-modified proRNA.
Martin, A. R.; Lavergne, T.; Vasseur, J.-J.; Debart, F.
Bioorg. Med. Chem. Lett. 2009, 19, 4046-4049. https://doi.org/10.1016/j.bmcl.2009.06.015
33. Efficient release of base-sensitive oligonucleotides from solid supports using fluoride ions.
Lavergne, T.; Parey, N.; Vasseur, J.-J.; Debart, F.
Eur. J. Org. Chem. 2009, 2190-2194. https://doi.org/10.1002/ejoc.200801275.
32. A base-labile group for 2′-OH protection of ribonucleosides: a major challenge for RNA synthesis.
Lavergne, T.; Bertrand, J.-R.; Vasseur, J.-J.; Debart, F.
Chem. Eur. J. 2008, 14, 9135-9138. https://doi.org/10.1002/chem.200801392.
31. 5-propynylamino a-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic a-oligonucleotides.
Deglane, G.; Morvan, F.; Debart, F.; Vasseur, J.-J.
Bioorg. Med. Chem. Lett. 2007, 17, 951-954.
30. Chemical Modifications to Improve the Cellular Uptake of Oligonucleotides.
Debart, F.; Abes, S.; Deglane, G.; Moulton, H. M.; Clair, P.; Gait, M. J.; Vasseur, J.-J.; Lebleu, B.
Curr. Top. Med. Chem. 2007, 7, 727-737.
29. First evaluation of acyloxymethyl or acylthiomethyl groups as biolabile 2′-O-protections of RNA.
Parey, N.; Baraguey, C.; Vasseur, J.-J.; Debart, F.
Org. Lett. 2006, 8 (17), 3869-3872. https://doi.org/10.1021/ja00036a076.
28. Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.
Johnson, A. A.; Sayer, J. M.; Yagi, H.; Patil, S. S.; Debart, F.; Maier, M. A.; Corey, D. R.; Vasseur, J.-J.; Burke, J., T. R.; Marquez, V. E.; Jerina, D. m.; Pommier, Y.
J. Biol. Chem. 2006, 281 (43), 32428-32438.
27. Impact of the guanidinium group on hybridisation and cellular uptake of cationic oligonucleotides.
Deglane, G.; Abes, Y.; Michel, T.; Prévot, P.; Vivès, E.; Debart, F.; Lebleu, B.; Vasseur, J.-J.
ChemBioChem 2006, 7 (4), 684-692.
26. Highly stable DNA triplex formed with cationic phosphoramidate pyrimidine a-oligonucleotides.
Michel, T.; Debart, F.; Heitz, F.; Vasseur, J.-J.,
ChemBioChem 2005, 6, 1254-1262.
25. Towards high yield synthesis of peptide-oligonucleotide chimera through a disulfide bridge: a simplified method for oligonucleotide activation.
Maurel, F.; Debart, F.; Cavelier, F.; Thierry, A. R.; Lebleu, B.; Vasseur, J.-J.; Vivès, E.
Bioorg. Med. Chem. Lett. 2005, 15, 5084-5087.
24. Cationic phosphoramidate a-oligonucleotides efficiently target single-stranded DNA and RNA and inhibit hepatitis C virus IRES-mediated translation.
Michel, T.; Martinand-Mari, C.; Debart, F.; Lebleu, B.; Robbins, I.; Vasseur, J.-J.
Nucleic Acids Res. 2003, 31 (18), 5282-5290.
23. FTIR and UV spectroscopy studies of triplex formation between a-oligonucleotides with non-ionic phosphoramidate linkages and DNA targets.
Michel, T.; Debart, F.; Vasseur, J.-J.; Geinguenaud, F.; Taillandier, E.
J. Biomol. Struct. Dyn. 2003, 21 (3), 435-445.
22. Efficient Guanidination of the phosphate linkage towards cationic phosphoramidate oligonucleotides.
Michel, T.; Debart, F.; Vasseur, J.-J.
Tetrahedron Lett. 2003, 44 (35), 6579-6582.
21. FTIR and UV spectroscopy studies of triplex formation between pyrimidine methoxyethylphosphoramidates a-oligodeoxynucleotides and ds DNA targets.
Sun, B.-W.; Geinguenaud, F.; Taillandier, E.; Naval, M.; Laurent, A.; Debart, F.; Vasseur, J.-J.
J. Biomol. Struct. Dyn. 2002, 19 (6), 1073-1081.
20. 2-amino-a-2′-deoxyadenosine increased duplex stability of methoxyethylphosphoramidate a-oligodeoxynucleotides with RNA target.
Naval, M.; Michel, T.; Vasseur, J.-J.; Debart, F.
Bioorg. Med. Chem. Lett. 2002, 12, 1435-1438.
19. Use of MALDI-TOF mass spectrometry to monitor solid-phase synthesis of oligonucleotides.
Guerlavais, T.; Meyer, A.; Debart, F.; Imbach, J.-L.; Morvan, F.; Vasseur, J.-J.
Anal. Bioanal. Chem. 2002, 374, 57-63.
18. Chiral and steric effects in the efficient binding of [alpha]-anomeric deoxyoligonucleoside N-alkylphosphoramidates to ssDNA and RNA.
Laurent, A.; Naval, M.; Debart, F.; Vasseur, J.-J.; Rayner, B.
Nucleic Acids Res. 1999, 27 (21), 4151-4159.
17. Anomeric inversion (from b to a) in methylphosphonate oligonucleosides enhances their affinity for DNA and RNA.
Debart, F.; Meyer, A.; Vasseur, J.-J.; Rayner, B.,
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16. A new route to oligodeoxynucleoside phosphoramidates (P-NH2).
Laurent, A.; Debart, F.; Rayner, B.
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15. Esterase-triggered fluorescence of fluorogenic oligonucleotides.
Laurent, A.; Debart, F.; Lamb, N.; Rayner, B.
Bioconjugate Chem. 1997, 8, 856-861.
14. Chimeric alpha-beta oligonucleotides as antisense inhibitors of reverse transcription.
Boizeau, C.; Debart, F.; Rayner, B.; Imbach, J.-L.; Toulme, J.-J.
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13. Efficient and stereoselective synthesis of 3′-deoxy 3′-C-branched-chain substituted thymidine.
Sanghvi, Y.; Bharadwaj, R.; Debart, F.; De Mesmaeker, A.
Synthesis 1994, 11, 1163-1166.
12. Optimization of hybridizing abilities and nuclease resistance in the design of chimeric a-anomeric oligodeoxynucleotides containing b-anomeric gaps.
Debart, F.; Tosquellas, G.; Rayner, B.; Imbach, J.-L.
Bioorg. Med. Chem. Lett. 1994, 4, 1041-1046.
11. Oligonucleosides: synthesis of a novel methylhydroxylamine linked nucleoside dimer and its incorporation into antisense sequences.
Vasseur, J.-J.; Debart, F.; Sanghvi, Y.; Cook, P. D.
J. Am. Chem. Soc. 1992, 114, 4006-4007. https://doi.org/10.1021/ja00036a076.
10. Intermolecular radical C-C bond formation: synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides.
Debart, F.; Vasseur, J.-J.; Sanghvi, Y.; Cook, P. D.
Tetrahedron Lett. 1992, 33, 2645-2648.
9. Synthesis and incorporation of methylenoxy(methylimino) linked thymidine dimer into antisense oligonucleosides.
Debart, F.; Vasseur, J.-J.; Sanghvi, Y.; Cook, P. D.,
Bioorg. Med. Chem. Lett. 1992, 2, 1479-1482.
8. Synthesis and base-pairing properties of the nuclease-resistant a-anomeric dodecaribonucleotide a-[r(UCUUAACCCACA)].
Debart, F.; Rayner, B.; Degols, G.; Imbach, J.-L.
Nucleic Acids Res. 1992, 20, 1193-1200. https://doi.org/10.1093/nar/20.6.1193.
7. Synthesis, DNA binding properties and biological evaluation of novel oligo-meta-benzamides related to Netropsin.
Debart, F.; Gosselin, G.; Rayner, B.; Le Ber, P.; Auclair, C.; Balzarini, J.; De Clercq, E.; Paoletti, C.; Imbach, J.-L.
Eur. J. Med. Chem. 1991, 26, 261-271.
6. Caractérisation de nouveaux dérivés de la Nétropsine et identification de leurs intermédiaires de synthèse par spectrométrie de masse FAB.
Aubagnac, J.-L.; Debart, F.; Mrani, D.; Gosselin, G.; Rayner, B.; Imbach, J.-L.
J. Heterocycl. Chem. 1991, 28, 145-151.
5. Sugar modified oligonucleotides: II. Solid phase synthesis of nuclease resistant a-anomeric uridylates as potential antisense agents.
Debart, F.; Rayner, B.; Imbach, J.-L.
Tetrahedron Lett. 1990, 31, 3537-3540.
4. Synthesis, DNA binding and biological evaluation of synthetic precursors and novel analogues of Netropsin.
Debart, F.; Périgaud, C.; Gosselin, G.; Mrani, D.; Rayner, B.; Le Ber, P.; Auclair, C.; Balzarini, J.; De Clercq, E.; Paoletti, C.; Imbach, J.-L.
J. Med. Chem. 1989, 32, 1075-1083.
3. Structure and conformation of the duplex consensus 5′-splice site d[(CpApApGpTpApApGpT) . (ApCpTpTpApCpCpTpG)] deduced from high field 1H-NMR of the non-exchangeable and imino protons.
Debart, F.; Rayner, B.; Imbach, J.-L.; Lee, M.; Chang, D.-K.; Pon, R. T.; Lown, J. W.
J. Biomol. Struct. Dyn. 1987, 5, 47-65.
2. 1H and 31P-NMR assignments of the non-exchangeable protons of the consensus acceptor exon : intron junction d(CpTpApCpApGpGpT).
Lown, J. W.; Chang, D.-K.; Debart, F.; Rayner, B.; Imbach, J.-L.
J. Biomol. Struct. Dyn. 1986, 3, 1171-1187.
1. Structure and conformation of the duplex consensus acceptor exon : intron junction d[(CpTpApCpApGpGpT) . (ApCpCpTpGpTpApG)] deduced from high field 1H-NMR of non-exchangeable and imino protons.
Debart, F.; Rayner, B.; Imbach, J.-L.; Chang, D.-K.; Lown, J. W.
J. Biomol. Struct. Dyn. 1986, 4, 343-363.